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Initiation of a conserved trophectoderm program in human, cow and mouse embryos

mercredi 23 septembre 2020 par Claudia Gerri, Afshan McCarthy, Gregorio Alanis-Lobato, Andrej Demtschenko, Alexandre Bruneau, Sophie Loubersac, Norah M. E. Fogarty, Daniel Hampshire, Kay Elder, Phil Snell, Leila Christie, Laurent David, Hilde Van de Velde, Ali A. Fouladi-Nashta, Kathy K. Niakan
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2759-xComparative analysis of human, cow and mouse embryos shows that a mechanism involving atypical protein kinase C initiates the trophectoderm program during the morula stage in these three (...)

Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B

mercredi 23 septembre 2020 par Ting-Hai Xu, Minmin Liu, X. Edward Zhou, Gangning Liang, Gongpu Zhao, H. Eric Xu, Karsten Melcher, Peter A. Jones
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2747-1Catalytically inactive DNMT3B3 is crucial in de novo CpG methylation of DNA, interacting with the nucleosome core to orient catalytically active DNMT3A2 so that it can bind to nearby linker (...)

Light-driven post-translational installation of reactive protein side chains

mercredi 23 septembre 2020 par Brian Josephson, Charlie Fehl, Patrick G. Isenegger, Simon Nadal, Tom H. Wright, Adeline W. J. Poh, Ben J. Bower, Andrew M. Giltrap, Lifu Chen, Christopher Batchelor-McAuley, Grace Roper, Oluwatobi Arisa, Jeroen B. I. Sap, Akane Kawamura, Andrew J. Baldwin, Shabaz Mohammed, Richard G. Compton, Veronique Gouverneur, Benjamin G. Davis
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2733-7A wide range of side chains are installed into proteins by addition of photogenerated alkyl or difluroalkyl radicals, providing access to new functionality and reactivity in (...)

Synthetic group A streptogramin antibiotics that overcome Vat resistance

mercredi 23 septembre 2020 par Qi Li, Jenna Pellegrino, D. John Lee, Arthur A. Tran, Hector A. Chaires, Ruoxi Wang, Jesslyn E. Park, Kaijie Ji, David Chow, Na Zhang, Axel F. Brilot, Justin T. Biel, Gydo van Zundert, Kenneth Borrelli, Dean Shinabarger, Cindy Wolfe, Beverly Murray, Matthew P. Jacobson, Estelle Mühle, Olivier Chesneau, James S. Fraser, Ian B. Seiple
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2761-3Modular synthesis and structural biology are used to design and characterize group A streptogramin antibiotics, one of which has activity against streptogramin-resistant strains and demonstrates efficacy in a mouse model (...)

Fractional antiferromagnetic skyrmion lattice induced by anisotropic couplings

mercredi 23 septembre 2020 par Shang Gao, H. Diego Rosales, Flavia A. Gómez Albarracín, Vladimir Tsurkan, Guratinder Kaur, Tom Fennell, Paul Steffens, Martin Boehm, Petr Čermák, Astrid Schneidewind, Eric Ressouche, Daniel C. Cabra, Christian Rüegg, Oksana Zaharko
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2716-8Theoretically predicted fractional antiferromagnetic skyrmions are experimentally realized in MnSc2S4 and are found to originate from anisotropic couplings over nearest neighbours in the crystal (...)

Third-order nanocircuit elements for neuromorphic engineering

mercredi 23 septembre 2020 par Suhas Kumar, R. Stanley Williams, Ziwen Wang
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2735-5Electrophysical processes are used to create third-order nanoscale circuit elements, and these are used to realize a transistorless network that can perform Boolean operations and find solutions to a computationally hard (...)

Zebrafish prrx1a mutants have normal hearts

mercredi 23 septembre 2020 par Federico Tessadori, Dennis E. M. de Bakker, Lindsey Barske, Nellie Nelson, Hermine A. Algra, Sven Willekers, James T. Nichols, J. Gage Crump, Jeroen Bakkers
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2674-1Zebrafish prrx1a mutants have normal hearts

Maternal microbes support fetal brain wiring

mercredi 23 septembre 2020 par Katherine R. Meckel, Drew D. Kiraly
Nature, Published online: 23 September 2020; doi:10.1038/d41586-020-02657-yResident bacteria in the maternal gut are important for normal fetal brain development in mice. It emerges that this effect is driven by bacterially produced metabolite molecules that signal to the fetal (...)

Local exposure to inequality raises support of people of low wealth for taxing the wealthy

mercredi 23 septembre 2020 par Melissa L. Sands, Daniel de Kadt
Nature, Published online: 23 September 2020; doi:10.1038/s41586-020-2763-1Local exposure to inequality in low-income areas is positively associated with support for a tax on wealthier individuals to address economic disparities.

Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

mercredi 23 septembre 2020 par Daniel J. Blair, Martin D. Burke
Nature, Published online: 23 September 2020; doi:10.1038/d41586-020-02565-1An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of (...)

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