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Measurement of the quantum geometric tensor and of the anomalous Hall drift

mercredi 19 février 2020 par A. Gianfrate, O. Bleu, L. Dominici, V. Ardizzone, M. De Giorgi, D. Ballarini, G. Lerario, K. W. West, L. N. Pfeiffer, D. D. Solnyshkov, D. Sanvitto, G. Malpuech
Nature, Published online: 19 February 2020; doi:10.1038/s41586-020-1989-2Direct measurement of the Berry curvature and the quantum metric of photonic modes in a high-finesse planar microcavity is achieved, enabling quantitative prediction of the independently measured anomalous Hall (...)

Caveolae in CNS arterioles mediate neurovascular coupling

mercredi 19 février 2020 par Brian W. Chow, Vicente Nuñez, Luke Kaplan, Adam J. Granger, Karina Bistrong, Hannah L. Zucker, Payal Kumar, Bernardo L. Sabatini, Chenghua Gu
Nature, Published online: 19 February 2020; doi:10.1038/s41586-020-2026-1Caveolae in arteriolar endothelial cells—but not those in neighbouring smooth muscle cells—have a key role in neurovascular coupling, an essential function for meeting acute brain energy (...)

Structural basis of ligand recognition and self-activation of orphan GPR52

mercredi 19 février 2020 par Xi Lin, Mingyue Li, Niandong Wang, Yiran Wu, Zhipu Luo, Shimeng Guo, Gye-Won Han, Shaobai Li, Yang Yue, Xiaohu Wei, Xin Xie, Yong Chen, Suwen Zhao, Jian Wu, Ming Lei, Fei Xu
Nature, Published online: 19 February 2020; doi:10.1038/s41586-020-2019-0Structures of the orphan G-protein-coupled receptor GPR52 in ligand-free, G-protein-coupled and ligand-bound states reveal that extracellular loop 2 occupies the orthosteric binding pocket and functions as a built-in (...)

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

mercredi 19 février 2020 par Bo Hu, Chengcheng Jin, Xing Zeng, Jon M. Resch, Mark P. Jedrychowski, Zongfang Yang, Bhavna N. Desai, Alexander S. Banks, Bradford B. Lowell, Diane Mathis, Bruce M. Spiegelman
Nature, Published online: 19 February 2020; doi:10.1038/s41586-020-2028-zVγ6+ Vδ1+ γδ T cells control tolerance to cold by activating adipocyte IL-17RC and promoting sympathetic innervation of thermogenic adipose tissue in mice.

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

mercredi 19 février 2020 par Susanne C. van den Brink, Anna Alemany, Vincent van Batenburg, Naomi Moris, Marloes Blotenburg, Judith Vivié, Peter Baillie-Johnson, Jennifer Nichols, Katharina F. Sonnen, Alfonso Martinez Arias, Alexander van Oudenaarden
Nature, Published online: 19 February 2020; doi:10.1038/s41586-020-2024-3Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal (...)

Will the latest UK Research Excellence Framework turn out to be the last?

mercredi 19 février 2020
Nature, Published online: 19 February 2020; doi:10.1038/d41586-020-00451-4The REF is unpopular but researchers should beware unintended consequences if it is abolished.

Closed-loop optimization of fast-charging protocols for batteries with machine learning

mercredi 19 février 2020 par Peter M. Attia, Aditya Grover, Norman Jin, Kristen A. Severson, Todor M. Markov, Yang-Hung Liao, Michael H. Chen, Bryan Cheong, Nicholas Perkins, Zi Yang, Patrick K. Herring, Muratahan Aykol, Stephen J. Harris, Richard D. Braatz, Stefano Ermon, William C. Chueh
Nature, Published online: 19 February 2020; doi:10.1038/s41586-020-1994-5A closed-loop machine learning methodology of optimizing fast-charging protocols for lithium-ion batteries can identify high-lifetime charging protocols accurately and efficiently, considerably reducing the experimental (...)

The ones who got away from Time and Loss

mercredi 19 février 2020 par Andrea Kriz
Nature, Published online: 19 February 2020; doi:10.1038/d41586-020-00470-1A moment to reflect.

A self-activating orphan receptor

mercredi 19 février 2020 par Brian Krumm, Bryan L. Roth
Nature, Published online: 19 February 2020; doi:10.1038/d41586-020-00411-yThe first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering (...)

The next chapter for African genomics

mercredi 19 février 2020 par Amy Maxmen
Nature, Published online: 19 February 2020; doi:10.1038/d41586-020-00454-1Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way.

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