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2021: Anti-amyloid antibodies take a bumpy road to the clinic

jeudi 26 septembre 2024 par Michael Eisenstein

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02952-yThe arrival of the first disease-modifying therapy for Alzheimer’s was significant, but it was not met with the joy that might have been expected.

Nature

2020: A blood-borne biomarker for Alzheimer’s disease

jeudi 26 septembre 2024 par Jerome Staal

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02950-0The discovery and validation of a diagnostic marker in plasma could be an important step for monitoring disease progression.

Nature

1987: Finding the first Alzheimer’s gene

jeudi 26 septembre 2024 par Linda Koch

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02884-7Mutations in the gene encoding APP, the precursor to amyloid-β, are found to underpin some cases of familial Alzheimer’s disease.

Nature

2008: Exploring the role of inflammation and immunity in Alzheimer’s disease

jeudi 26 septembre 2024 par Kirsty Minton

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02948-8Genetic evidence kick-starts research into the involvement of microglia cells and the innate immune system in the development of the disease.

Nature

1999: A vaccine raises hopes of treatment for Alzheimer’s disease

jeudi 26 septembre 2024 par Lucy Bird

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02946-wImmunizing mice against amyloid-β is shown not only to prevent plaques forming, but also to clear away existing deposits.

Nature

1984: Identifying amyloid-? in brain plaques

jeudi 26 septembre 2024 par Lisa Heinke

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02882-9Evidence mounts that these peptides are the key component of plaques associated with Alzheimer’s and might give rise to the disease.

Nature

Carbon bond that uses only one electron seen for first time: ‘It will be in the textbooks’

jeudi 26 septembre 2024 par Katherine Bourzac

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-03138-2The fundamental discovery deepens scientists’ understanding of chemical bonding.

Nature

My mission to protect threatened mangroves

jeudi 26 septembre 2024 par Dom Byrne

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02901-9Wetlands ecologist Sigit Sasmito describes how growing up in rural Indonesia influenced his interest in peatlands and mangroves.

Nature

1993: A major genetic risk factor for late-onset Alzheimer’s disease

jeudi 26 septembre 2024 par Henry Ertl

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02885-6The APOE gene, which codes for a fat-binding protein in the brain, is identified as a strong genetic risk factor for the most common form of the disease.

Nature

2013: Genetic risk factors for Alzheimer’s uncovered by large meta-analysis

jeudi 26 septembre 2024 par Margot Brandt

Nature, Published online: 26 September 2024; doi:10.1038/d41586-024-02949-7A study of nearly 75,000 people doubled the number of areas of the human genome that were known to be associated with late-onset disease.

Nature