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AlphaFold is running out of data — so drug firms are building their own version

jeudi 27 mars 2025 par Ewen Callaway

Nature, Published online: 27 March 2025; doi:10.1038/d41586-025-00868-9Thousands of 3D protein structures locked up in big-pharma vaults will be used to create a new AI tool that won’t be open to academics.

Nature

75% of US scientists who answered Nature poll consider leaving

jeudi 27 mars 2025 par Alexandra Witze

Nature, Published online: 27 March 2025; doi:10.1038/d41586-025-00938-yMore than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

Nature

How Trump is following Project 2025’s radical roadmap to defund science

jeudi 27 mars 2025 par Dan Garisto

Nature, Published online: 27 March 2025; doi:10.1038/d41586-025-00780-2Much of the Trump administration’s agenda for research is laid out in the 900-plus-page blueprint. Nature read it so you don’t have to.

Nature

‘Open source’ AI isn’t truly open — here’s how researchers can reclaim the term

jeudi 27 mars 2025 par Stefano Maffulli

Nature, Published online: 27 March 2025; doi:10.1038/d41586-025-00930-6Many firms are misusing the ‘open source’ label. The scientific community, which relies on transparency and replicability, must resist this trend.

Nature

Long-term impact and biological recovery in a deep-sea mining track

mercredi 26 mars 2025 par Daniel O. B. Jones, Maria Belen Arias, Loïc Van Audenhaege, Sabena Blackbird, Corie Boolukos, Guadalupe Bribiesca-Contreras, Jonathan T. Copley, Andrew Dale, Susan Evans, Bethany F. M. Fleming, Andrew R. Gates, Hannah Grant, Mark G. J. Hartl, Veerle A. I. Huvenne, Rachel M. Jeffreys, Pierre Josso, Lucas D. King, Erik Simon-Lledó, Tim Le Bas, Louisa Norman, Bryan O’Malley, Thomas Peacock, Tracy Shimmield, Eva C. D. Stewart, Andrew K. Sweetman, Catherine Wardell, Dmitry Aleynik, Adrian G. Glover

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08921-3Long-term impact and biological recovery in a deep-sea mining track

Nature

The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

mercredi 26 mars 2025 par Meimei Liao, Yanqin Liu, Zhancong Xu, Mingxu Fang, Ziqing Yu, Yufan Cui, Zhengda Sun, Ran Huo, Jieyu Yang, Fusheng Huang, Mingming Liu, Qin Zhou, Xiaocui Song, Hui Han, She Chen, Xiaodong Xu, Ximing Qin, Qun He, Dapeng Ju, Tao Wang, Nirav Thakkar, Paul E. Hardin, Susan S. Golden, Eric Erquan Zhang

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08797-3A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic (...)

Nature

The global human impact on biodiversity

mercredi 26 mars 2025 par François Keck, Tianna Peller, Roman Alther, Cécilia Barouillet, Rosetta Blackman, Eric Capo, Teofana Chonova, Marjorie Couton, Lena Fehlinger, Dominik Kirschner, Mara Knüsel, Lucile Muneret, Rebecca Oester, Kálmán Tapolczai, Heng Zhang, Florian Altermatt

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08752-2Key measures of biodiversity were quantified and found to be affected by human pressures that shifted community composition and decreased local diversity across terrestrial, freshwater and marine (...)

Nature

A human brain map of mitochondrial respiratory capacity and diversity

mercredi 26 mars 2025 par Eugene V. Mosharov, Ayelet M. Rosenberg, Anna S. Monzel, Corey A. Osto, Linsey Stiles, Gorazd B. Rosoklija, Andrew J. Dwork, Snehal Bindra, Alex Junker, Ya Zhang, Masashi Fujita, Madeline B. Mariani, Mihran Bakalian, David Sulzer, Philip L. De Jager, Vilas Menon, Orian S. Shirihai, J. John Mann, Mark D. Underwood, Maura Boldrini, Michel Thiebaut de Schotten, Martin Picard

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08740-6The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization and enzymatic oxidation (...)

Nature

Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3

mercredi 26 mars 2025 par Kelvin Y. Chen, Tatsuya Kibayashi, Ambre Giguelay, Mayu Hata, Shunsuke Nakajima, Norihisa Mikami, Yusuke Takeshima, Kenji Ichiyama, Ryusuke Omiya, Leif S. Ludwig, Kunihiro Hattori, Shimon Sakaguchi

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08795-5The RBPJ–NCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T (...)

Nature

Changes in neurotensin signalling drive hedonic devaluation in obesity

mercredi 26 mars 2025 par Neta Gazit Shimoni, Amanda J. Tose, Charlotte Seng, Yihan Jin, Tamás Lukacsovich, Hongbin Yang, Jeroen P. H. Verharen, Christine Liu, Michael Tanios, Eric Hu, Jonathan Read, Lilly W. Tang, Byung Kook Lim, Lin Tian, Csaba Földy, Stephan Lammel

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08748-yIn mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linked to neurons projecting (...)

Nature