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A maternal brain hormone that builds bone

mardi 9 juillet 2024 par Muriel E. Babey, William C. Krause, Kun Chen, Candice B. Herber, Zsofia Torok, Joni Nikkanen, Ruben Rodriguez, Xiao Zhang, Fernanda Castro-Navarro, Yuting Wang, Erika E. Wheeler, Saul Villeda, J. Kent Leach, Nancy E. Lane, Erica L. Scheller, Charles K. F. Chan, Thomas H. Ambrosi, Holly A. Ingraham

Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07634-3A brain-derived hormone, CCN3, is newly identified to have a role as an osteoanabolic factor to build bone in lactating females and in the viability of offspring.

Nature

Dissociable hindbrain GLP1R circuits for satiety and aversion

mardi 9 juillet 2024 par Kuei-Pin Huang, Alisha A. Acosta, Misgana Y. Ghidewon, Aaron D. McKnight, Milena S. Almeida, Nathaniel T. Nyema, Nicholas D. Hanchak, Nisha Patel, Yenoukoume S. K. Gbenou, Alice E. Adriaenssens, Kevin A. Bolding, Amber L. Alhadeff

Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07685-6The neural circuits in the hindbrain that link satiety and aversion are shown to be separate, raising the possibility of developing obesity drugs without the common side effects of nausea and (...)

Nature

Plasticity in single-crystalline Mg₃Bi₂ thermoelectric material

mardi 9 juillet 2024 par Peng Zhao, Wenhua Xue, Yue Zhang, Shizhen Zhi, Xiaojing Ma, Jiamin Qiu, Tianyu Zhang, Sheng Ye, Huimin Mu, Jinxuan Cheng, Xiaodong Wang, Shuaihang Hou, Lijia Zhao, Guoqiang Xie, Feng Cao, Xingjun Liu, Jun Mao, Yuhao Fu, Yumei Wang, Qian Zhang

Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07621-8The thermoelectric material Mg3Bi2 is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of (...)

Nature

Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

mardi 9 juillet 2024 par Florian Gaertner, Hellen Ishikawa-Ankerhold, Susanne Stutte, Wenwen Fu, Jutta Weitz, Anne Dueck, Bhavishya Nelakuditi, Valeria Fumagalli, Dominic van den Heuvel, Larissa Belz, Gulnoza Sobirova, Zhe Zhang, Anna Titova, Alejandro Martinez Navarro, Kami Pekayvaz, Michael Lorenz, Louisa von Baumgarten, Jan Kranich, Tobias Straub, Bastian Popper, Vanessa Zheden, Walter Anton Kaufmann, Chenglong Guo, Guido Piontek, Saskia von Stillfried, Peter Boor, Marco Colonna, Sebastian Clauß, Christian Schulz, Thomas Brocker, Barbara Walzog, Christoph Scheiermann, William C. Aird, Claus Nerlov, Konstantin Stark, Tobias Petzold, Stefan Engelhardt, Michael Sixt, Robert Hauschild, Martina Rudelius, Robert A. J. Oostendorp, Matteo Iannacone, Matthias Heinig, Steffen Massberg

Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07671-yPlasmacytoid dendritic cells monitor the bone marrow for apoptotic megakaryocytes (MKs) and deliver IFNα to the MK niche, triggering local on-demand proliferation and maturation of MK (...)

Nature

Brainstem Dbh⁺ neurons control allergen-induced airway hyperreactivity

mardi 9 juillet 2024 par Yujuan Su, Jinhao Xu, Ziai Zhu, Jisun Chin, Le Xu, Haoze Yu, Victoria Nudell, Barsha Dash, Esteban A. Moya, Li Ye, Axel Nimmerjahn, Xin Sun

Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07608-5Mapping a full allergen circuit from the lung to the brainstem and back, repeated exposure of mice to inhaled allergen activated the nuclei of solitary tract neurons in a mast cell-, interleukin-4- and vagal nerve-dependent (...)

Nature

Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

mardi 9 juillet 2024 par Calvin Law, Vanessa Sue Wacleche, Ye Cao, Arundhati Pillai, John Sowerby, Brandon Hancock, Alice Horisberger, Sabrina Bracero, Viktoriya Skidanova, Zhihan Li, Ifeoluwakiisi Adejoorin, Eilish Dillon, Isaac J. Benque, Diana Pena Nunez, Daimon P. Simmons, Joshua Keegan, Lin Chen, Tina Baker, Phillip Z. Brohawn, Hussein Al-Mossawi, Ling-Yang Hao, Brian Jones, Navin Rao, Yujie Qu, Stephen E. Alves, Jennifer Albrecht, Jennifer H. Anolik, William Apruzzese, Jennifer L. Barnas, Joan M. Bathon, Ami Ben-Artzi, Brendan F. Boyce, David L. Boyle, S. Louis Bridges Jr., Vivian P. Bykerk, Debbie Campbell, Arnold Ceponis, Adam Chicoine, Michelle Curtis, Kevin D. Deane, Edward DiCarlo, Laura T. Donlin, Patrick Dunn, Andrew Filer, Hayley Carr, Gary S. Firestein, Lindsy Forbess, Laura Geraldino-Pardilla, Susan M. Goodman, Ellen M. Gravallese, Peter K. Gregersen, Joel M. Guthridge, Maria Gutierrez-Arcelus, V. Michael Holers, Diane Horowitz, Laura B. Hughes, Lionel B. Ivashkiv, Kazuyoshi Ishigaki, Judith A. James, A. Helena Jonsson, Joyce B. Kang, Gregory Keras, Ilya Korsunsky, Amit Lakhanpal, James A. Lederer, Miles J. Lewis, Yuhong Li, Katherine Liao, Arthur M. Mandelin II, Ian Mantel, Kathryne E. Marks, Mark Maybury, Andrew McDavid, Mandy J. McGeachy, Joseph R. Mears, Nida Meednu, Nghia Millard, Larry Moreland, Saba Nayar, Alessandra Nerviani, Dana E. Orange, Harris Perlman, Costantino Pitzalis, Javier Rangel-Moreno, Soumya Raychaudhuri, Karim Raza, Yakir Reshef, Christopher Ritchlin, Felice Rivellese, William H. Robinson, Laurie Rumker, Ilfita Sahbudin, Saori Sakaue, Jennifer A. Seifert, Dagmar Scheel-Toellner, Anvita Singaraju, Kamil Slowikowski, Melanie Smith, Darren Tabechian, Paul J. Utz, Gerald F. M. Watts, Kevin Wei, Kathryn Weinand, Dana Weisenfeld, Michael Weisman, Qian Xiao, Fan Zhang, Zhu Zhu, Andrew Cordle, Aaron Wyse, Katharina S. Shaw, Ruth Ann Vleugels, Elena Massarotti, Karen H. Costenbader, Michael B. Brenner, Judd F. Hultquist, Jaehyuk Choi, Deepak A. Rao

Nature, Published online: 10 July 2024; doi:10.1038/s41586-024-07627-2Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates (...)

Nature

Breastfeeding should break down mothers’ bones — here’s why it doesn’t

mardi 9 juillet 2024 par Benjamin Thompson, Nick Petri? Howe

Nature, Published online: 10 July 2024; doi:10.1038/d41586-024-02286-9A hormone discovered in mice could help keep bones healthy during lactation, and a new way to edit genes in the gut microbiome.

Nature

How anti-obesity drugs cause nausea: finding offers hope for better drugs

mardi 9 juillet 2024 par Mariana Lenharo

Nature, Published online: 10 July 2024; doi:10.1038/d41586-024-02254-3The neurons that produce a sick feeling and food aversion are distinct from those that induce a feeling of fullness.

Nature

Scientists edit the genes of gut bacteria in living mice

mardi 9 juillet 2024 par Gemma Conroy

Nature, Published online: 10 July 2024; doi:10.1038/d41586-024-02238-3A ‘base editor’ successfully modified a gene in more than 90% of Escherichia coli bacteria without unwanted side effects.

Nature

Massive cicada emergence prompted raccoons to run wild

mardi 9 juillet 2024

Nature, Published online: 10 July 2024; doi:10.1038/d41586-024-02264-1Meanwhile, deer kept a low profile — perhaps because the deafening noise of the insects made it hard to hear predators.

Nature