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Intragenic DNA inversions expand bacterial coding capacity

mercredi 25 septembre 2024 par Rachael B. Chanin, Patrick T. West, Jakob Wirbel, Matthew O. Gill, Gabriella Z. M. Green, Ryan M. Park, Nora Enright, Arjun M. Miklos, Angela S. Hickey, Erin F. Brooks, Krystal K. Lum, Ileana M. Cristea, Ami S. Bhatt

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07970-4Reversible DNA inversions found entirely within genes enable increased coding capacity by encoding multiple versions of a protein in bacteria and archaea.

Nature

Transferrin receptor targeting chimeras for membrane protein degradation

mercredi 25 septembre 2024 par Dingpeng Zhang, Jhoely Duque-Jimenez, Francesco Facchinetti, Garyk Brixi, Kaitlin Rhee, William W. Feng, Pasi A. Jänne, Xin Zhou

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07947-3Transferrin receptor targeting chimeras have been developed that enable targeting of drug resistance in epidermal growth factor receptor-driven lung cancer and reversible control of human primary chimeric antigen (...)

Nature

The genetic architecture of protein stability

mercredi 25 septembre 2024 par Andre J. Faure, Aina Martí-Aranda, Cristina Hidalgo-Carcedo, Antoni Beltran, Jörn M. Schmiedel, Ben Lehner

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07966-0By experimentally sampling from sequence spaces larger than 1010 and using thermodynamic models, the genetic structure of at least some proteins can be well described, indicating that protein genetics is simpler than (...)

Nature

Larger and more instructable language models become less reliable

mercredi 25 septembre 2024 par Lexin Zhou, Wout Schellaert, Fernando Martínez-Plumed, Yael Moros-Daval, Cèsar Ferri, José Hernández-Orallo

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07930-yScaling up and shaping up large language models increased their tendency to provide sensible yet incorrect answers at difficulty levels humans cannot supervise, highlighting the need for a fundamental shift in artificial (...)

Nature

Human hippocampal and entorhinal neurons encode the temporal structure of experience

mercredi 25 septembre 2024 par Pawel Tacikowski, Güldamla Kalender, Davide Ciliberti, Itzhak Fried

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07973-1Single-neuron recordings from intracranial electrodes inserted into human brains for clinical reasons suggest that the temporal structure of human experience is encoded in human hippocampal and entorhinal (...)

Nature

Jet stream controls on European climate and agriculture since 1300 ce

mercredi 25 septembre 2024 par Guobao Xu, Ellie Broadman, Isabel Dorado-Liñán, Lara Klippel, Matthew Meko, Ulf Büntgen, Tom De Mil, Jan Esper, Björn Gunnarson, Claudia Hartl, Paul J. Krusic, Hans W. Linderholm, Fredrik C. Ljungqvist, Francis Ludlow, Momchil Panayotov, Andrea Seim, Rob Wilson, Diana Zamora-Reyes, Valerie Trouet

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07985-xTree-ring records used to reconstruct the variability of the European jet stream from 1300 to 2004 ce show modulation of extreme regional climate events and extensive impacts on agriculture and human (...)

Nature

Author Correction: An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption

mercredi 25 septembre 2024 par Feng Zhang, Bo Zhang, Yuying Wang, Runmin Jiang, Jin Liu, Yuexian Wei, Xinyue Gao, Yichao Zhu, Xinli Wang, Mao Sun, Junjun Kang, Yingying Liu, Guoxing You, Ding Wei, Jiajia Xin, Junxiang Bao, Meiqing Wang, Yu Gu, Zhe Wang, Jing Ye, Shuangping Guo, Hongyan Huang, Qiang Sun

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-08057-wAuthor Correction: An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption

Nature

Bronze Age clash was Europe’s oldest known interregional battle

mercredi 25 septembre 2024

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-03090-1Artefacts found in modern-day Germany suggest that northern and southern peoples clashed in the Tollense Valley millennia ago.

Nature

A dwarf planet has dirty depths, model suggests

mercredi 25 septembre 2024

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-03088-9Analysis finds that the mini-world Ceres hosts a frozen ocean that is progressively filled with impurities farther from the surface.

Nature

Children with Down’s syndrome are more likely to get leukaemia: stem-cells hint at why

mercredi 25 septembre 2024 par Benjamin Thompson, Emily Bates

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-03161-3Restructuring of genome sections creates conditions that increase blood cancer risk — plus, the latest from the Nature Briefing.

Nature