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Efficiency-optimized relativistic plasma harmonics for extreme fields

mercredi 22 avril 2026 par Robin J. L. Timmis, Colm R. J. Fitzpatrick, Jonathan P. Kennedy, Holly M. Huddleston, Elliott Denis, Abigail James, Chris Baird, Dan Symes, David McGonegle, Eduard Atonga, Heath Martin, Jeremy Rebenstock, John Neely, Jordan Lee, Joshua Redfern, Nicolas Bourgeois, Oliver Finlay, Rusko Ruskov, Sam Astbury, Steve Hawkes, Zixin Zhang, Matt Zepf, Karl Krushelnick, Edward Gumbrell, Paramel Pattathil Rajeev, Mark Yeung, Brendan Dromey, Peter Norreys

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10400-2Tailoring relativistic laser–plasma interactions on femtosecond timescales unlocks a direct route to extreme field generation using a coherent harmonic focus.

Nature

Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years

mercredi 22 avril 2026 par Luoying Jiang, Xiaoting Cheng, Jun Lv, Yuxin Chen, Xiaoyun Chen, Rongqun Zhai, Liqin Zhang, Lei Han, Yiling Zhang, Juhong Zhang, Di Deng, Zhicheng Huang, Qi Cao, Xin Zhang, Daqi Wang, Yizhe Wang, Liheng Chen, Sha Yu, Luo Guo, Bowen Zhang, Hui Wang, Yi Zhou, Liling Dai, Wei Wang, Longlong Zhang, Yanbo Yin, Guiqing Cheng, Ziyi Zhou, Wuqing Wang, Bing Chen, Wei Lu, Hongqun Jiang, Zhiqiang Gao, Dazhi Shi, Yuanping Xiong, Yu Zhao, Wei Yuan, Qin Wang, Guodong Feng, Huawei Li, Zheng-Yi Chen, Yilai Shu

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10393-yIn a multicentre trial of AAV1-hOTOF gene therapy involving 42 participants aged 0.8–32.3 years with autosomal recessive deafness 9, treatment demonstrated safety, tolerability, and improved hearing and speech perception, (...)

Nature

Dynamics of genetic and somatic trade-offs in ageing and mortality

mercredi 22 avril 2026 par Danny Arends, David G. Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur G. Centeno, Kurt H. Lamour, João Pedro de Magalhães, Pjotr Prins, Karl W. Broman, Saunak Sen, Sarah J. Mitchell, Michael R. MacArthur, Özlem Altintas Akin, Xiaoxu Li, Amandeep Bajwa, Vivian Diaz, David E. Harrison, Randy Strong, James F. Nelson, Khyobeni Mozhui, Johan Auwerx, Evan G. Williams, Richard A. Miller, Robert W. Williams

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10407-9Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that influence lifespan and mortality with divergent age- and sex-specific effects, as well as 30 loci (...)

Nature

Focal white matter lesions drive grey matter inflammation and synapse loss

mercredi 22 avril 2026 par Omar de Faria Jr, Stavros Vagionitis, Andrea Lopez-Lopez, Michael Perry, Joseph Jo Yin Wong, Leslie Rodríguez-Kirby, Bastien Hervé, Balazs Viktor Varga, Eneritz Agirre, Sabrina Ghosh, Sebastian Timmler, Mert Yucel, Andrew T. Setley, Kimberley Anne Evans, Tanja Mist Birgisdóttir, Sindri Gíslason, Yan Ting Ng, Courtney Kremler, Helene O. B. Gautier, Yasmine Kamen, Helena Pivonkova, Katrin Volbracht, Felix Hildebrand, Christian A. Cepeda, Javier Rueda-Carrasco, Soyon Hong, George Malliaras, Sabine Dietmann, Gonçalo Castelo-Branco, Ragnhildur Thóra Káradóttir

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10414-wA transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative (...)

Nature

Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

mercredi 22 avril 2026 par Baosen Jia, Yuhua Shi, Yourae Hong, Chongbo Yang, Dylan Roycroft, Shahida Kamal, Sushmita Mukherjee, Beatrix Ueberheide, Alex Grier, Ellen Scherl, Dana Lukin, Randy Longman, Vinita Jacob, Laura Sahyoun, Michael Mintz, Jennifer Claytor, Robbyn Sockolow, Aliza Solomon, Thomas Ciecierega, Arielle Bergman, Kimberley Chien, Kenny Joselin Castro Ochoa, Elliott Gordon, Lily Barash, Melissa Rose, Kelly Garrett, Fabrizio Michelassi, Jeffrey Milsom, David Artis, Gregory Sonnenberg, Caitlin Mason, Victoria Ribeiro de Godoy, Adriana Brcic-Susak, Dario Garone, Chloe Scott, Lexi Tempera, Mavee Witherspoon, Maneeza Bilal, Bing He, Lauretta A. Lacko, Steven M. Lipkin, Sabine Tejpar, J. Magarian Blander

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10343-8CASP5 expression is restricted to the human intestinal epithelium, and the CASP5C isoform has a key role in promoting Wnt signalling, which is required for epithelial homeostasis, through binding to dishevelled and cleavage (...)

Nature

This robot can beat you at table tennis

mercredi 22 avril 2026 par Shamini Bundell

Nature, Published online: 22 April 2026; doi:10.1038/d41586-026-01343-9The AI-powered arm learnt the sport from scratch and can now beat top players.

Nature

Evaluating large language models for accuracy incentivizes hallucinations

mercredi 22 avril 2026 par Adam Tauman Kalai, Ofir Nachum, Santosh S. Vempala, Edwin Zhang

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10549-wEvaluating large language models for accuracy incentivizes hallucinations

Nature

Ubiquitination of glycogen and metabolites in cells and tissues

mercredi 22 avril 2026 par Marco Jochem, Simon A. Cobbold, Craig A. Goodman, Catharina Kueng, Anthony Cerra, Laura F. Fielden, Man Lyang Kim, Philipp Schenk, Ria Agarwal, Xiangyi S. Wang, Simon R. Scutts, Michael Pandos, Lin Tang, Thomas Hermanns, Shane M. Devine, Martin Brzozowski, Yuri Shibata, Niall D. Geoghegan, Catriona A. McLean, Bernhard C. Lechtenberg, Kay Hofmann, Paul Gregorevic, David Komander

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10548-xUbiquitination of glycogen and metabolites in cells and tissues

Nature

Daily briefing: Should we worry about AI doomsday?

mardi 21 avril 2026 par Flora Graham

Nature, Published online: 21 April 2026; doi:10.1038/d41586-026-01331-zWhat researchers think about the validity, and risk, of AI doomsday scenarios. Plus, a social network for agentic AI bots and how personalized CRISPR therapies could reach more people who need (...)

Nature

How big is Big G? Mystery deepens after ten-year effort to measure gravity’s strength

mardi 21 avril 2026 par Elizabeth Gibney

Nature, Published online: 21 April 2026; doi:10.1038/d41586-026-01284-3Physicists have spent the past decade trying to pin down the elusive fundamental constant, to no avail.

Nature