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Engineering tough blood clots for rapid haemostasis and enhanced regeneration

mercredi 29 avril 2026 par Shuaibing Jiang, Guangyu Bao, Zhen Yang, Jing Wu, Xingwei Yang, Joo Eun June Kim, Roselyn Jiang, Ying Zhan, Alexander Nottegar, Yin Liu, Zu-hua Gao, Andrew Beckett, Anastasia Nijnik, Rong Long, Christian Kastrup, Jianyu Li

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10412-yEngineered blood clots using rapidly crosslinked red blood cells form within seconds, greatly improving toughness and adhesion while effectively stopping bleeding and enhancing tissue (...)

Nature

GLP-1R–GIPR–PPAR?/?/? quintuple agonism corrects obesity and diabetes in mice

mercredi 29 avril 2026 par Daniela Liskiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin, Jonathan E. Campbell, Pietra Candela, Russell L. Castelino, Callum Coupland, Maxime Culot, W. Scott Dodson, Jonathan D. Douros, Hannes Embring, Annette Feuchtinger, Brian Finan, Cristina Garcia-Caceres, Xiao-Bing Gao, Fabien Gosselet, Gerald Grandl, Robert M. Gutgesell, Daniel T. Haas, Martin Jastroch, Ezgi Karaoglu, Pamela Kakimoto, Anna Cristina Kaltenbach, Michaela Keuper, Christine M. Kusminski, Danielle C. Leander, Arkadiusz Liskiewicz, Xue Liu, Gandhari Maity-Kumar, Sara Martinez Martinez, Stephanie A. Mowery, Ruben Nogueiras, Marshall Paisley, Diego Perez-Tilve, Patricia S. S. Petersen, Paul T. Pfluger, Sneha Prakash, Sabine Steffens, Alberto Cebrian-Serrano, Monica Tost, Jordan Wean, Christian Weber, Junichi Yoshida, Zachary Gerhart-Hines, Tamas L. Horvath, Philipp E. Scherer, Randy J. Seeley, Richard D. DiMarchi, Matthias H. Tschöp, Natalie Krahmer, Patrick J. Knerr, Timo D. Müller

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10427-5GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction in vitro and in mouse models via synergistic incretin (...)

Nature

Increase in wild animal consumption across Central Africa

mercredi 29 avril 2026 par Mattia Bessone, Daniel J. Ingram, Katharine Abernethy, Sylvanus Abua, Sophie Allebone-Webb, Daniela Antonacci, Riyong Kim, Stephanie Brittain, Daniel Cornelis, Diane Detoeuf, Charles A. Emogor, Julia E. Fa, Steffen Foerster, Davy Fonteyn, Maria Grande Vega, Chloe Hodgkinson, Amy Ickowitz, Cédric Thibaut Kamogne Tagne, Della Kemalasari, Noëlle Kümpel, Simon Lhoest, Germain Mavah, Rodrigue Guy Mouanda Niamba, Donald Midoko Iponga, Eleanor J. Milner-Gulland, Jonas Muhindo, Théodore Munyuli, Robert Nasi, Steeve Ngama, Jonas Nyumu, Justin Ombeni, John R. Poulsen, Dominic Rowland, Yahya Sampurna, François Sandrin, Malcolm Starkey, Caleb Tata, Julius C. Tieguhong, Nathalie van Vliet, Philippe Vigneron, Robin C. Whytock, Michelle Wieland, David Wilkie, Jasmin Willis, Juliet Wright, Lauren Coad

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10422-wWild meat is a fundamental component of the diets of rural Central African populations, accounting for 20% of the recommended daily protein intake, compared with 13% and 6% for those living in towns and (...)

Nature

Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup

mercredi 29 avril 2026 par Bernhard Dumoulin, Jonathan Levinsohn, Konstantin A. Klötzer, Chenyu Li, Liran Mao, Eunji Ha, Samer Mohandes, Thao Nguyen, Luca Paruzzo, Daigoro Hirohama, Victoria Fang, Vijay G. Bhoj, Hamideh Parhiz, Magaiver Andrade-Silva, Amin Abedini, Andi Bergeson, Daniel Traum, Michael J. May, Klaus H. Kaestner, Marco Ruella, Fiona Elizabeth McAllister, A. Ari Hakimi, Mingyao Li, Matthew Palmer, E. John Wherry, Christopher A. Hunter, Michael Paul Cancro, Raymond Townsend, Gaia Coppock, Manisha Singh, Michael Ross, James Tumlin, Kirk Campbell, Amy Mottl, Christos Argyropoulos, Tamara Isakova, Salem Almaani, Rupali Avasare, Richard Lafayette, Julia Scialla, Randy Luciano, Shweta Bansal, Frank Brosius, Ankit Mehta, Oliver Lenz, Nelson Kopyt, Piettro Canetta, Matthias Kretzler, Jeffrey Schelling, Alexis Hofherr, Steven S. Pullen, Andrew Thorley, Ching Shang, Erding Hu, Anil Karihaloo, Kishor Devalaraja-Narashimha, Katalin Susztak

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10363-4A single-cell spatial atlas identifies a B cell-predominant microenvironment within the profibrotic tubular niche that marks a subset of patients with diabetic kidney disease with rapid (...)

Nature

Translation-dependent degradation of cas12 mRNA triggered by an anti-CRISPR

mercredi 29 avril 2026 par Nicole D. Marino, Alexander Talaie, Milan Gerovac, Jorge L. Rodriguez, Andrew D. Schmidt, Theresa J. Astmann, Héloïse Carion, Anya Flood Taylor, Jessica Liliedahl, Surabhi Haniyur, Kristi Zoga, Matthew C. Johnson, Leandro Buhlmann, Kuei-Ho Chen, Sukrit Silas, Yuping Li, Yang Zhang, Danielle L. Swaney, Jörg Vogel, Joseph Bondy-Denomy

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10440-8The anti-CRISPR protein AcrVA2 specifically interrupts Cas12a biogenesis by triggering co-translational mRNA degradation.

Nature

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex

mercredi 29 avril 2026 par Javier Guenaga, Monika Ádori, Shridhar Bale, Swastik Phulera, Ioannis Zygouras, Fabian-Alexander Schleich, Xaquin Castro Dopico, Sashank Agrawal, Miyo Ota, Richard Wilson, Jocelyn Cluff, Tamar Dzvelaia, Marco Mandolesi, Wen-Hsin Lee, Agnes A. Walsh, Mariane B. Melo, Laurent Verkoczy, Darrell J. Irvine, Martin Corcoran, Ian A. Wilson, Diane Carnathan, Guido Silvestri, Andrew B. Ward, Gabriel Ozorowski, Gunilla B. Karlsson Hedestam, Richard T. Wyatt

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10429-3A vaccination strategy using heterologous HIV Env trimers covalently coupled to liposomes for multivalent display generates cross-neutralizing HIV serum antibody responses in non-human primates, mimicking infection-elicited (...)

Nature

Transdimensional anomalous Hall effect in rhombohedral thin graphite

mercredi 29 avril 2026 par Qingxin Li, Hua Fan, Min Li, Yinghai Xu, Junwei Song, Anqi Wang, Kenji Watanabe, Takashi Taniguchi, Jing-Jing Chen, Zhenbing Tan, Jie Shen, Hua Jiang, James C. Hone, Cory R. Dean, Kostya S. Novoselov, Xin-Cheng Xie, Geliang Yu, Yue Zhao, Jianpeng Liu, Lei Wang

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10471-1The experimental observation of a fundamentally new type of anomalous Hall effect that couples both in-plane and out-of-plane orbital magnetizations in multilayer rhombohedral graphene is (...)

Nature

Improving access to essential medicines via decision-aware machine learning

mercredi 29 avril 2026 par Angel Tsai-Hsuan Chung, Jatu Abdulai, Patrick Bayoh, Lawrence Sandi, Francis Smart, Hamsa Bastani, Osbert Bastani

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10433-7Nationwide deployment of a novel decision-aware machine learning framework as a decision support tool for the allocation of essential medicines in Sierra Leone resulted in improved access to essential healthcare in this (...)

Nature

Digital quantum magnetism on a trapped-ion quantum computer

mercredi 29 avril 2026 par R. Haghshenas, E. Chertkov, M. Mills, W. Kadow, S.-H. Lin, Y. H. Chen, C. Cade, I. Niesen, T. Beguši?, M. S. Rudolph, C. Cirstoiu, K. Hémery, C. Mc Keever, M. Lubasch, E. Granet, C. H. Baldwin, J. P. Bartolotta, M. Bohn, J. J. Burau, J. Cline, M. DeCross, J. M. Dreiling, C. Foltz, D. Francois, J. P. Gaebler, C. N. Gilbreth, J. Gray, D. Gresh, A. Hall, A. Hankin, A. Hansen, N. Hewitt, C. A. Holliman, R. B. Hutson, M. Iqbal, N. Kotibhaskar, E. Lehman, D. Lucchetti, I. S. Madjarov, K. Mayer, A. R. Milne, S. A. Moses, B. Neyenhuis, G. Park, A. R. Perry, B. Ponsioen, M. Schecter, P. E. Siegfried, D. T. Stephen, B. G. Tiemann, M. D. Urmey, J. Walker, A. C. Potter, D. Hayes, G. K.-L. Chan, F. Pollmann, M. Knap, H. Dreyer, M. Foss-Feig

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10445-3Simulations performed using Quantinuum’s H2 trapped-ion quantum computer for observing thermalization on challenging timescales demonstrate the usefulness of digital quantum computers for investigating continuous-time (...)

Nature

Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1

mercredi 29 avril 2026 par Lambros Tselikas, Sandrine Susini, Matthieu Texier, Andrey Yurchenko, Emilie Routier, Mona Amini-Adle, Edi Tihic, Séverine Mouraud, François-Xavier Danlos, Samy Ammari, Thibault Raoult, Séverine Roy, Delphine Bredel, Siham Farhane, Lydie Cassard, Irma Molinaro, Alexander Eggermont, Jean-Charles Soria, Laurence Zitvogel, Christophe Massard, Angelo Paci, Thierry de Baere, Jean-Yves Scoazec, Nathalie Chaput, Sergey Nikolaev, Nicolas Meyer, Céleste Lebbé, Stéphane Dalle, Caroline Robert, Aurélien Marabelle

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10341-wThe phase 1b NIVIPIT trial shows that in combined therapy with intravenous nivolumab (anti-PD1), intratumoural administration of ipilimumab (anti-CTLA4) offers improved safety and greater efficacy compared with intravenous (...)

Nature