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Demography and life histories across the Roman frontier in Germany 400–700 ce

mercredi 29 avril 2026 par Jens Blöcher, Leonardo Vallini, Maren Velte, Raphael Eckel, Léa Guyon, Laura Winkelbach, Mark G. Thomas, Nadia Gharehbaghi, Cassandra T. Mitchell, Jonas Schümann, Sophie Köhler, Elsa Seyr, Katharina Krichel, Sophie Rau, Jana Hirsch, Jana Duras, Paul Cloarec-Pioffet, Andreas Füglistaler, Kristin Klement, Miriam Wilkenhöner, Lisa Vetterdietz, Francesca Gentilin, Melany Müller, Anna-Lena Mücke, Nicoletta Zedda, Youssef Tawfik, Eveline Saal, George McGlynn, Barbara Bramanti, Jörg Orschiedt, Regina Molitor, Barbara Fliß, Ines Spazier, David Shankland, Claus Vetterling, Kurt Karpf, Vera Planert, Stefan Hölzl, Silvia Codreanu-Windauer, Dieter Quast, Ilija Miki?, Sven Fiedler, Bernd Päffgen, Maxime Brami, Thomas Richter, Raphaëlle Chaix, Susanne Brather-Walter, Peter Steffens, Markus Marquart, Thomas Becker, Jochen Haberstroh, Mischa Meier, Sebastian Schmidt-Hofner, Sebastian Brather, Michaela Harbeck, Steffen Patzold, Daniel Wegmann, Joachim Burger

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10437-3Analysis of 258 ancient genomes from southern Germany reveals a major demographic shift during the late fifth century, yet family structures persisted from Late Roman times, demonstrating cultural continuity despite profound (...)

Nature

Prime assembly with linear DNA donors enables large genomic insertions

mercredi 29 avril 2026 par Bin Liu, Andrew Petti, Xuntao Zhou, Haoyang Cheng, Jenny Gao, Matthew Yee, Youwei Qiao, Yanjun Zhang, Lin Zhou, Scot A. Wolfe, Tingting Jiang, Erik J. Sontheimer, Wen Xue

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10460-4Prime assembly can initiate Gibson-like assembly in cells to generate gene insertions without double-stranded DNA breaks, recombinases or homology-directed (...)

Nature

Uncertain dynamic response of mid-latitude winter precipitation

mercredi 29 avril 2026 par Lei Gu, Dominik L. Schumacher, Sebastian Sippel, Erich M. Fischer, Istvan Dunkl, Robin Noyelle, Jitendra Singh, Lorenzo Pierini, Reto Knutti

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10474-ySeparating the anthropogenic forced thermodynamic and dynamic components from internal variability in winter precipitation trends in the mid-latitudes shows that thermodynamic effects agree with models and observations but (...)

Nature

The past, present and future of de novo protein design

mercredi 29 avril 2026 par Wei Yang, Shunzhi Wang, Gyu Rie Lee, Jason Z. Zhang, Alexis Courbet, David Juergens, Xinru Wang, Thomas Schlichthaerle, Mohamad Abedi, Robert Ragotte, Linna An, Indrek Kalvet, Sam Pellock, Ljubica Mihaljevic, Cameron Glasscock, Arvind Pillai, Adam Broerman, Nathan Ennist, Ella Haefner, Nora McNamara-Bordewick, Ian Haydon, Lance Stewart, Gaurav Bhardwaj, David Baker

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10328-7A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.

Nature

Evolutionary characterization of lung cancer metastasis

mercredi 29 avril 2026 par Sonya Hessey, Abigail Bunkum, Ariana Huebner, Kerstin Haase, Kristiana Grigoriadis, Cristina Naceur-Lombardelli, Wing Kin Liu, Caitlin F. Harrigan, Charlotte Grieco, Daniele Marinelli, Boyue Ding, Carlos Martínez-Ruiz, Piotr Pawlik, Mark S. Hill, Olivia Lucas, Corentin Richard, Oriol Pich, Kerstin Thol, Takahiro Karasaki, Sophia Ward, Foteini Athanasopoulou, Monica Sivakumar, Selvaraju Veeriah, Antonia Toncheva, Andrew J. Rowan, Paulina Prymas, Hayley Bridger, Miriam Mitchison, Elaine Borg, Mary Falzon, Ian Proctor, Ula Mahadeva, Anna Green, Martin D. Forster, Sarah Benafif, Tanya Ahmad, Siow Ming Lee, Dionysis Papadatos-Pastos, Babu Naidu, Gerald Langman, Matthew G. Krebs, Pedro Oliveira, Fiona H. Blackhall, Yvonne Summers, Jamie Weaver, John Le Quesne, Anne Thomas, Cathy Richards, Dean A. Fennell, Sanjay Jogai, Judith Cave, Patricia Roxburgh, Sioban Fraser, Alan Kirk, Kevin G. Blyth, Peter Russell, Crispin T. Hiley, Allan Hackshaw, Jason F. Lester, Amrita Bajaj, Apostolos Nakas, Azmina Sodha-Ramdeen, Claire Wilson, Molly Scotland, Rebecca Boyles, Sean Dulloo, Sridhar Rathinam, Gurdeep Matharu, Jacqui A. Shaw, Ekaterini Boleti, Heather Cheyne, Gillian Price, Keith M. Kerr, Mohammed Khalil, Shirley Richardson, Tracey Cruickshank, Jack French, Kayleigh Gilbert, Akshay J. Patel, Aya Osman, Gary Middleton, Helen Shackleford, Madava Djearaman, Mandeesh Sangha, Angela Leek, Adam Atkin, Anshuman Chaturvedi, Antonio Paiva-Correia, Colin R. Lindsay, Eustace Fontaine, Felice Granato, Jack Davies Hodgkinson, Juliette Novasio, Katherine D. Brown, Kandadai Rammohan, Leena Joseph, Mathew Carter, Nicola Totton, Paul Bishop, Philip A. J. Crosbie, Sara Waplington, Jonathan Tugwood, Caroline Dive, Hugo JWL Aerts, Gareth A. Wilson, Aino-Maija Leppä, Alexander A. Azizi, Lydia Y. Liu, Jonas Demeulemeester, Miklos Diossy, Nicolai J. Birkbak, Peter Van Loo, Rachel Rosenthal, Roberto Salgado, Roland F. Schwarz, Tom L. Kaufmann, Zoltan Szallasi, Alexander M. Frankell, Angela Dwornik, Angeliki Karamani, Karen Grimes, Benny Chain, Carla Castignani, Chris Bailey, Cian Murphy, Clare E. Weeden, Clare Puttick, David R. Pearce, Despoina Karagianni, Dimitria Brempou, Emilia L. Lim, Emma C. Colliver, Emma Hazelwood, Emma Nye, Erik Sahai, Eva Grönroos, Francisco Gimeno-Valiente, Gemma Foulds, George Kassiotis, Georgia Moth, Georgia Stavrou, Helen L. Lowe, Ieva Usaite, Iva Mladenova, Jacki Goldman, James L. Reading, James R. M. Black, Jayant K. Rane, Jeanette Kittel, John A. Hartley, Jorge Martin Arana, Karl S. Peggs, Katey S. S. Enfield, Katherine Honan, Kayalvizhi Selvaraju, Kexin Koh, Krupa Thakkar, Leah Ensell, Lucrezia Patruno, Maise Al Bakir, Mansi Shah, Maria Litovchenko, Maria Zagorulya, Michalina Magala, Michelle M. Leung, Mickael Escudero, Mihaela Angelova, Nnennaya Kanu, Oliver Shutkever, Philip Hobson, Richard Kevin Stone, Rija Zaidi, Robert Bentham, Robert Goldstone, Roberto Vendramin, Sadegh Saghafinia, Samuel Gamble, Seng Kuong Anakin Ung, Sergio A. Quezada, Sharon Vanloo, Sian Harries, Stefan Boeing, Stephan Beck, Supreet Kaur Bola, Teresa Marafioti, Theepan Visakan, Thomas B. K. Watkins, Thomas Patrick Jones, Victoria Spanswick, Vittorio Barbè, Wei-Ting Lu, William Hill, Woody Z. Zhang, Yin Wu, Yutaka Naito, Zoe Ramsden, Catarina Veiga, Charles-Antoine Collins-Fekete, Francesco Fraioli, Gary Royle, Paul Ashford, Alexander James Procter, Arjun Nair, Asia Ahmed, David Lawrence, Davide Patrini, Emilie Martinoni Hoogenboom, Fleur Monk, James W. Holding, Junaid Choudhary, Kunal Bhakhri, Magali N. Taylor, Maria Chiara Pisciella, Neal Navani, Pat Gorman, Reena Khiroya, Ricky M. Thakrar, Robert CM Stephens, Sam M. Janes, Steve Bandula, Zoltan Kaplar, Aoife Walker, Camilla Pilotti, Rachel Leslie, Salomey Kellett, Anca Grapa, Hanyun Zhang, Khalid AbdulJabbar, Xiaoxi Pan, Yinyin Yuan, David Chuter, Mairead MacKenzie, Aiman Alzetani, Patricia Georg, Serena Chee, Eric Lim, Alexandra Rice, Anand Devaraj, Andrew G. Nicholson, Chiara Proli, Daniel Kaniu, Harshil Bhayani, Hema Chavan, Hilgardt Raubenheimer, Lyn Ambrose, Mpho Malima, Nadia Fernandes, Paulo De Sousa, Pratibha Shah, Sarah Booth, Silviu I. Buderi, Simon Jordan, Sofina Begum, Madeleine Hewish, Sarah Danson, Michael J. Shackcloth, Lily Robinson, Andrew Kidd, Craig Dick, Jennifer Whiteley, Mathew Thomas, Mohammed Asif, Nikos Kostoulas, Rocco Bilancia, Zainab Kalokoh, Elizabeth Keene, Theepan Vikasan, Karen Ambrose, Mike Gavrielides, Nitzan Rosenfeld, Amrit Roshan, Cecilie Agergaard Soerensen, Ben Solomon, Lavinia Tan, Ana Parreira, Corinne Faivre-Finn, Fabio Gomes, Igor Gomez-Randulfe, Jack Webster, Laura Cove-Smith, Pamela Maroa, Paul Taylor, Raffaele Califano, Sara Tenconi, Adam Peryt, Aman Coonar, Amanda Stone, Caroline Sanganee, Martin Goddard, Stephen Preston, Giuseppe Aresu, Jane Lichfield, Julia Knight, Lauren DSA, Maria Manuela Urda, Maria Nizami, Robert Rintoul, Zoe Armstrong, Abiya Mathew, Damalie Namwanja, Nicky Thomson, Philip Earwaker, Kai-Keen Shiu, John Bridgewater, Daniel Hochhauser, Tariq Enver, Ron Sinclair, Zoe Rhodes, Mark Linch, Sebastian Brandner, Heather Shaw, Gerhardt Attard, Faye Gishen, Francisco Gimeno Valiente, Adrienne Flanagan, Osvaldas Vainauskas, Anna Wingate, Daniel Wetterskog, A. M. Mahedi Hasan, Stefano Lise, Gianmarco Leone, Anuradha Jayaram, Constantine Alifrangis, Ursula McGovern, Kerry Bowles, Athanasia Vargiamiou, Christopher Aled Chamberlain, Welles Robinson, Iain McNeish, Nataly Ojeda Mosquera, Jiali Liu, Felix O’Farrell, Chenelle Marcel, Samra Turajlic, James Larkin, Lisa Pickering, Andrew Furness, Kate Young, Will Drake, Kim Edmonds, Nikki Hunter, Mary Mangwende, Lauren Grostate, Lavinia Spain, Scott Shepherd, Haixi Yan, Benjamin Shum, Zayd Tippu, Brian Hanley, Charlotte Spencer, Max Emmerich, Camille Gerard, Eleanor Carlyle, Steve Hazell, Hardeep Mudhar, Christina Messiou, Arash Latifoltojar, Annika Fendler, Fiona Byrne, Husayn Pallikonda, Irene Lobon, Alexander Coulton, Anne-Laure Cattin, Daqi Deng, Hugang Feng, Nadia Yousaf, Sanjay Popat, Charlotte Milner-Watts, Aida Murra, Justine Korteweg, Lauren Terry, Jennifer Biano, Kema Peat, Emma Turay, Peter Hill, Marija Miletic, Anadil Javaid, Jennifer Thomas, Bakir Kudic, Orla McGowan, Dharmista Ramesh, Oznur Saka, Sinem Arslan, Laura Marandino, Reina Ammar, Gurneet Kapur, Dilruba Kabir, David McMahon, Alexius John, Foteini Kalofonou, Debra Josephs, Sheeba Irshad, James Spicer, Ruby Stewart, Natasha Wright, Ruxandra Mitu, Deborah Enting, Sarah Rudman, Sharmistha Ghosh, Eleni Lena Karapanagiotou, Elias Pintus, Andrew Tutt, James D. Brenton, Nicola Thompson, Rebecca Fitzgerald, Merche Jimenez-Linan, Elena Provenzano, Anna Paterson, Kieren Allinson, Grant D. Stewart, Ultan McDermott, Tim Maughan, Olaf Ansorge, Peter Campbell, Mat Carter, Charlotte Poile, Kudazyi H. Kutywayo, Maurice R. Dungey, Jens Claus Hahne, Shobhit Baijal, Charlotte Ferris, Hollie Bancroft, Amy Kerr, Joanne Webb, Salma Kadiri, Bernard Olisemeke, Rodelaine Wilson, Ian Tomlinson, Luke Nolan, Samantha Holden, Tania Fernandes, Mairead McKenzie, Shivani Patel, David A. Moore, Simone Zaccaria, Nicholas McGranahan, Charles Swanton, Mariam Jamal-Hanjani

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10428-4DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and (...)

Nature

Pervasive and programmed nucleosome distortion on single chromatin fibres

mercredi 29 avril 2026 par Marty G. Yang, Hannah J. Richter, Simai Wang, Colin P. McNally, Camille M. Moore, Ali Emadi, Nicole E. Harris, Simaron Dhillon, Michela Maresca, Huimin Pan, Hayden Saunders, Ruiqiao Yang, Megan S. Ostrowski, Erika C. Anderson, Elzo de Wit, Jacquelyn J. Maher, Yuhong Fan, Geeta J. Narlikar, Elphège P. Nora, Holger Willenbring, Hani Goodarzi, Vijay Ramani

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10418-6An analytical pipeline called Iteratively Defined Lengths of Inaccessibility (IDLI) maps the genome-wide occupancy of a range of nucleosome types and shows that most nucleosomes exhibit programmed ‘distortion’, in which the (...)

Nature

Charge-dependent spectral softenings of primary cosmic rays below the knee

mercredi 29 avril 2026 par Francesca Alemanno, Qi An, Philipp Azzarello, Felicia-Carla-Tiziana Barbato, Paolo Bernardini, Xiao-Jun Bi, Hugo Boutin, Irene Cagnoli, Ming-Sheng Cai, Elisabetta Casilli, Jin Chang, Deng-Yi Chen, Jun-Ling Chen, Zhan-Fang Chen, Zi-Xuan Chen, Paul Coppin, Ming-Yang Cui, Tian-Shu Cui, Ivan De Mitri, Francesco de Palma, Adriano Di Giovanni, Tie-Kuang Dong, Zhen-Xing Dong, Giacinto Donvito, Jing-Lai Duan, Kai-Kai Duan, Rui-Rui Fan, Yi-Zhong Fan, Fang Fang, Kun Fang, Chang-Qing Feng, Lei Feng, Sara Fogliacco, Jennifer-Maria Frieden, Piergiorgio Fusco, Min Gao, Fabio Gargano, Essna Ghose, Ke Gong, Yi-Zhong Gong, Dong-Ya Guo, Jian-Hua Guo, Shuang-Xue Han, Yi-Ming Hu, Guang-Shun Huang, Xiao-Yuan Huang, Yong-Yi Huang, Maria Ionica, Lu-Yao Jiang, Wei Jiang, Yao-Zu Jiang, Jie Kong, Andrii Kotenko, Dimitrios Kyratzis, Shi-Jun Lei, Bo Li, Manbing Li, Wen-Hao Li, Wei-Liang Li, Xiang Li, Xian-Qiang Li, Yao-Ming Liang, Cheng-Ming Liu, Hao Liu, Jie Liu, Shu-Bin Liu, Yang Liu, Francesco Loparco, Miao Ma, Peng-Xiong Ma, Tao Ma, Xiao-Yong Ma, Giovanni Marsella, Mario-Nicola Mazziotta, Dan Mo, Yu Nie, Xiao-Yang Niu, Andrea Parenti, Wen-Xi Peng, Xiao-Yan Peng, Chiara Perrina, Enzo Putti-Garcia, Rui Qiao, Jia-Ning Rao, Yi Rong, Ritabrata Sarkar, Pierpaolo Savina, Andrea Serpolla, Zhi Shangguan, Wei-Hua Shen, Zhao-Qiang Shen, Zhong-Tao Shen, Leandro Silveri, Jing-Xing Song, Hong Su, Meng Su, Hao-Ran Sun, Zhi-Yu Sun, Antonio Surdo, Xue-Jian Teng, Andrii Tykhonov, Gui-Fu Wang, Jin-Zhou Wang, Lian-Guo Wang, Shen Wang, Xiao-Lian Wang, Yan-Fang Wang, Da-Ming Wei, Jia-Ju Wei, Yi-Feng Wei, Di Wu, Jian Wu, Sha-Sha Wu, Xin Wu, Zi-Qing Xia, Zheng Xiong, En-Heng Xu, Hai-Tao Xu, Jing Xu, Zhi-Hui Xu, Zun-Lei Xu, Zi-Zong Xu, Guo-Feng Xue, Ming-Yu Yan, Hai-Bo Yang, Peng Yang, Ya-Qing Yang, Hui-Jun Yao, Yu-Hong Yu, Qiang Yuan, Chuan Yue, Jing-Jing Zang, Sheng-Xia Zhang, Wen-Zhang Zhang, Yan Zhang, Ya-Peng Zhang, Yi Zhang, Yong-Jie Zhang, Yong-Qiang Zhang, Yun-Long Zhang, Zhe Zhang, Zhi-Yong Zhang, Cong Zhao, Hong-Yun Zhao, Xun-Feng Zhao, Chang-Yi Zhou, Xun Zhu, Yan Zhu

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10472-0The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% (...)

Nature

Higher-order interactions enhance the latitudinal tree diversity gradient

mercredi 29 avril 2026 par Yuanzhi Li, Junli Xiao, Yuan Jiang, Stuart Joseph Wright, Margaret M. Mayfield, Oscar Godoy, Alfonso Alonso, Kristina J. Anderson-Teixeira, Jennifer Baltzer, Joseph D. Birch, Pulchérie Bissiengou, Norman A. Bourg, Warren Brockelman, David F. R. P. Burslem, Min Cao, Keith Clay, Stuart J. Davies, Qingqing Du, Sisira Ediriweera, Anna Feistner, Edwino S. Fernando, Gregory S. Gilbert, Zhanqing Hao, Jan Holík, Mingxi Jiang, Guangze Jin, Daniel J. Johnson, Alexander S. Jones, Kamil Král, Andrew J. Larson, Buhang Li, Juyu Lian, Luxiang Lin, Feng Liu, Yu Liu, Zhili Liu, James A. Lutz, Keping Ma, Sean M. McMahon, William McShea, Hervé Roland Memiaghe, Xiangcheng Mi, Jonathan A. Myers, Musalmah Nasardin, Anuttara Nathalang, Michael J. O’Brien, Nestor Laurier Engone Obiang, Geoffrey Parker, Richard P. Phillips, Xiujuan Qiao, Haibao Ren, Glen Reynolds, Lillian Jennifer V. Rodriguez, Pavel Šamonil, Guochun Shen, Zufei Shu, Jessica Shue, Mark E. Swanson, Jill Thompson, María Uriarte, Xihua Wang, Xugao Wang, Youshi Wang, Tze Leong Yao, Wanhui Ye, Mingjian Yu, Minhua Zhang, Yan Zhu, Jess Zimmerman, Fangliang He, Chengjin Chu

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10434-6Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global forests, potentially explaining why this intricate phenomenon cannot be adequately explained by (...)

Nature

Cytoplasmic competition between separate parental pronuclei in zygotes

mercredi 29 avril 2026 par Hirohisa Kyogoku, Mitsusuke Tarama, Masahiro Matsuwaka, Tappei Mishina, Akihito Harada, Reiko Nakagawa, Mami Kumon, Yoshihiro Shimizu, Yasuyuki Ohkawa, Tatsuo Shibata, Azusa Inoue, Tomoya S. Kitajima

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10417-7Drug-based and manipulation-based strategies provide evidence of pronuclear competition for finite cytoplasmic resources between separate parental pronuclei in zygotes, suggesting a cell biological mechanism for the (...)

Nature

Training language models to be warm can reduce accuracy and increase sycophancy

mercredi 29 avril 2026 par Lujain Ibrahim, Franziska Sofia Hafner, Luc Rocher

Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10410-0Experiments on five different language models show that training language models to produce warmer responses can undermine the accuracy of their output, especially when users express feelings of (...)

Nature