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Distinct genetic architecture in the tails of complex traits

mercredi 27 mai 2026 par T. Souaiaia, H. M. Wu, A. P. S. Ori, S. W. Choi, C. J. Hoggart, P. F. O’Reilly

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10516-5Genome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at the tails of the phenotypic spectrum compared with common (...)

Nature

Sparse-to-dense coding transformation between hippocampal areas CA3 and CA1

mercredi 27 mai 2026 par Shir R. Maimon, Tamir Eliav, Johnatan Aljadeff, Aviya Shalev, Yishai Gronich, Nikita M. Finger, Keegan E. Eveland, Cynthia F. Moss, Liora Las, Nachum Ulanovsky

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10537-0The hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.

Nature

Technology mediation in child sexual exploitation and abuse in Africa and Asia

mercredi 27 mai 2026 par Sakshi Ghai, Matti Vuorre, Daniel Kardefelt-Winther, Amanda M. Ferguson, Sebastian Kurten, Sonia Livingstone, Andrew K. Przybylski, Amy Orben

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10525-4Enabling parental mediation of online activities and children’s knowledge of where to seek help after sexual harassment or assault is associated with higher rates of disclosure of technology-facilitated (...)

Nature

?KG-mediated carnitine synthesis drives DNA repair via histone acetylation

mercredi 27 mai 2026 par Apoorva Uboveja, Baixue Yang, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan R. Cole, Julie A. Disharoon, Richard S. Fang, Evan Levasseur, Miho Naruse, Zhentai Huang, Emily Megill, Daniel S. Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M. Marcinkiewicz, Sarah Graff, Ellen De Pieri, Andrea Andress Huacachino, Frank P. Vendetti, Jeff Danielson, Erika S. Dahl, Jennifer L. Pennise, Esther Elishaev, Alison Jaccard, Lauren Borho, Miriam D. Post, Kristine Cooper, Francesmary Modugno, Nadine Hempel, Wayne Stallaert, Christopher J. Bakkenist, Simone Sidoli, Kathryn E. Wellen, Benjamin G. Bitler, David T. Long, Nathaniel W. Snyder, Katherine M. Aird

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10584-7The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications for chemoresistant (...)

Nature

Four ppm measurement of the antihydrogen ground-state hyperfine splitting

mercredi 27 mai 2026 par R. Akbari, L. O. de Araujo Azevedo, C. J. Baker, W. Bertsche, N. M. Bhatt, G. Bonomi, A. Capra, I. Carli, C. L. Cesar, M. Charlton, A. Cridland Mathad, A. Del Vincio, D. Duque Quiceno, S. Eriksson, A. Evans, J. Fajans, T. Friesen, M. C. Fujiwara, L. M. Golino, M. B. Gomes Gonçalves, J. S. Hangst, M. E. Hayden, P. Heidari, D. Hodgkinson, C. A. Isaac, S. A. Jones, S. Jonsell, N. Madsen, V. R. Marshall, J. T. K. McKenna, T. Momose, J. Nauta, A. N. Oliveira, A. Powell, C. Ø. Rasmussen, T. Robertson-Brown, F. Robicheaux, R. L. Sacramento, E. Sarid, J. Schoonwater, D. M. Silveira, J. Singh, G. Smith, C. So, S. Stracka, J. Suh, A. G. Swadling, T. D. Tharp, K. A. Thompson, R. I. Thompson, E. Thorpe-Woods, A. J. Uribe Jimenez, M. Urioni, D. P. van de Werf, S. G. Wilson, P. Woosaree, J. S. Wurtele

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10556-xA measurement of the hyperfine splitting energy of the ground state of antihydrogen at 4 ppm precision reaches a point at which this result is sensitive to the internal structure of the (...)

Nature

Darkness and body size shaped end-Cretaceous marine extinction patterns

mercredi 27 mai 2026 par Rui Ying, Fanny M. Monteiro, James D. Witts, Daniela N. Schmidt

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10541-4Trait-based ecosystem modelling shows that impact-driven darkness and body-size-dependent extinction thresholds, rather than carbon-dioxide increase or acidification, drove most of the observed end-Cretaceous marine extinction (...)

Nature

Human haematopoietic stem cells remember inflammatory stress

mercredi 27 mai 2026 par Andy G. X. Zeng, Murtaza S. Nagree, Niels Asger Jakobsen, Sayyam Shah, Angelica Varesi, Jasmine Ryu Won Kang, Alex Murison, Jin-Gyu Cheong, Sven Turkalj, Xuan Zhang, Felix A. Radtke, Tsega-Ab Abera, Isabel N. X. Lim, Liqing Jin, Joana Araújo, Alicia G. Aguilar-Navarro, Darrien Parris, Jessica McLeod, Hyerin Kim, Ho Seok Lee, Lin Zhang, Mason Boulanger, Elyssa Bader, Elias Gbeha, Christopher N. Parkhurst, Elvin Wagenblast, Eugenia Flores-Figueroa, Bo Wang, Gregory W. Schwartz, Leonard D. Shultz, Anna S. Nam, H. Leighton Grimes, Steven Z. Josefowicz, Philip Awadalla, Paresh Vyas, John E. Dick, Stephanie Z. Xie

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10522-7Using xenograft inflammation–recovery models and single-cell multiomics, a haematopoietic stem cell population after inflammatory stress is identified.

Nature

?-Arrestin condensates regulate G-protein-coupled receptor function

mercredi 27 mai 2026 par Preston J. Anderson, Peng Xiao, Ya-Ni Zhong, Adam N. Kaakati, Juliana Alfonso-DeSouza, Alejandra Patino, Andrew Ahn, Chanpreet Jassal, Tianyao Zhang, Chao Zhang, Kexin Yu, Lei Qi, Wei Ding, Samuel Liu, Biswaranjan Pani, Athmika Krishnan, Oscar Chen, Joseph Strawn, Joshua C. Snyder, Jin-Peng Sun, Sudarshan Rajagopal

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10539-yβ-Arrestins, multifunctional adaptor proteins that regulate G-protein-coupled receptors (GPCRs), form phase-separated condensates, suggesting that β-arrestin liquid–liquid phase separation organizes and diversifies GPCR (...)

Nature

Bohmian mechanics remains unchallenged by tunnelling experiment

mercredi 27 mai 2026 par Aurélien Drezet, Dustin Lazarovici, Bernard Michael Nabet

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10450-6Bohmian mechanics remains unchallenged by tunnelling experiment

Nature

Author Correction: Satellite megaconstellations will threaten space-based astronomy

mercredi 27 mai 2026 par Alejandro S. Borlaff, Pamela M. Marcum, Steve B. Howell

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10553-0Author Correction: Satellite megaconstellations will threaten space-based astronomy

Nature