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A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

mercredi 26 mars 2025 par Manoj Jangra, Dmitrii Y. Travin, Elena V. Aleksandrova, Manpreet Kaur, Lena Darwish, Kalinka Koteva, Dorota Klepacki, Wenliang Wang, Maya Tiffany, Akosiererem Sokaribo, Brian K. Coombes, Nora Vázquez-Laslop, Yury S. Polikanov, Alexander S. Mankin, Gerard D. Wright

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08723-7A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no (...)

Nature

Deconstruction of rubber via C–H amination and aza-Cope rearrangement

mercredi 26 mars 2025 par Sydney E. Towell, Maxim Ratushnyy, Lauren S. Cooke, Geoffrey M. Lewis, Aleksandr V. Zhukhovitskiy

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08716-6Deconstruction of rubber is achieved using C–H amination and aza-Cope rearrangement to provide precursors for epoxy resins.

Nature

irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA

mercredi 26 mars 2025 par Luca Ducoli, Brian J. Zarnegar, Douglas F. Porter, Robin M. Meyers, Weili Miao, Nicholas M. Riley, Suhas Srinivasan, Leandra V. Jackrazi, Yen-Yu Yang, Zhouxian Li, Yinsheng Wang, Carolyn R. Bertozzi, Ryan A. Flynn, Paul A. Khavari

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08787-5EGF-induced recruitment of UPF1 adjacent to HNRNPC induces splicing surveillance of cell proliferation mRNAs.

Nature

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures

mercredi 26 mars 2025 par Anish Kumar Mondal, Elisa Carrillo, Vasanthi Jayaraman, Edward C. Twomey

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08770-0Physiological temperatures augment activation of glutamate receptors, which enables the structural basis of neuronal excitation to be elucidated.

Nature

BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

mercredi 26 mars 2025 par Sudipta Lahiri, George Hamilton, Gemma Moore, Liana Goehring, Tony T. Huang, Ryan B. Jensen, Eli Rothenberg

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08749-xThe tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors.

Nature

Solidification of Earth’s mantle led inevitably to a basal magma ocean

mercredi 26 mars 2025 par Charles-Édouard Boukaré, James Badro, Henri Samuel

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08701-zAs the early Earth solidified, gravitational segregation of dense, iron-rich melts drove mantle evolution, injecting geochemical signatures of shallow silicate fractionation into the deep mantle and inevitably forming a (...)

Nature

Gene-modified pig-to-human liver xenotransplantation

mercredi 26 mars 2025 par Kai-Shan Tao, Zhao-Xu Yang, Xuan Zhang, Hong-Tao Zhang, Shu-Qiang Yue, Yan-Ling Yang, Wen-Jie Song, De-Sheng Wang, Zheng-Cai Liu, Hai-Min Li, Yong Chen, Rui Ding, Shi-Ren Sun, Ming Yu, Ji-Peng Li, Wei-Xun Duan, Zhe Wang, Jing-Wen Wang, Jia-Yun Liu, Min-Wen Zheng, Xi-Jing Zhang, Wen Yin, Wei-Jun Qin, Dong-Mei Bian, Lin Li, Min Li, Zhi-Bin Lin, Hao Xu, Dan Wei, Hong Zhang, Juan-Li Duan, Deng-Ke Pan, Hai-Long Dong, Lin Wang, Ke-Feng Dou

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08799-1A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver (...)

Nature

The contribution of de novo coding mutations to meningomyelocele

mercredi 26 mars 2025 par Yoo-Jin Jiny Ha, Ashna Nisal, Isaac Tang, Chanjae Lee, Ishani Jhamb, Cassidy Wallace, Robyn Howarth, Sarah Schroeder, Keng loi Vong, Naomi Meave, Fiza Jiwani, Chelsea Barrows, Sangmoon Lee, Nan Jiang, Arzoo Patel, Krisha Bagga, Niyati Banka, Liana Friedman, Francisco A. Blanco, Seyoung Yu, Soeun Rhee, Hui Su Jeong, Isaac Plutzer, Michael B. Major, Béatrice Benoit, Christian Poüs, Caleb Heffner, Zoha Kibar, Gyang Markus Bot, Hope Northrup, Kit Sing Au, Madison Strain, Allison E. Ashley-Koch, Richard H. Finnell, Joan T. Le, Hal S. Meltzer, Camila Araujo, Helio R. Machado, Roger E. Stevenson, Anna Yurrita, Sara Mumtaz, Awais Ahmed, Mulazim Hussain Khara, Osvaldo M. Mutchinick, José Ramón Medina-Bereciartu, Friedhelm Hildebrandt, Gia Melikishvili, Ahmed I. Marwan, Valeria Capra, Mahmoud M. Noureldeen, Aida M. S. Salem, Mahmoud Y. Issa, Maha S. Zaki, Libin Xu, Ji Eun Lee, Donghyuk Shin, Anna Alkelai, Alan R. Shuldiner, Stephen F. Kingsmore, Stephen A. Murray, Heon Yung Gee, W. Todd Miller, Kimberley F. Tolias, John B. Wallingford, Allison E. Ashley Koch, Philip J. Lupo, Camila Araújo, Tony Magana, Caroline M. Kolvenbach, Shirlee Shril, Yukitoshi Takahashi, Hormos Salimi-Dafsari, H. Westley Phillips, Brian Hanak, Bülent Kara, Ayfer Sakarya Güne?, David D. Gonda, Salman Kirmani, Tinatin Tkemaladze, Sangwoo Kim, Joseph G. Gleeson

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08676-xExome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube (...)

Nature

Oxidation of retromer complex controls mitochondrial translation

mercredi 26 mars 2025 par Junbing Zhang, Md Yousuf Ali, Harrison Byron Chong, Pei-Chieh Tien, James Woods, Carolina Noble, Tristan Vornbäumen, Zehra Ordulu, Anthony P. Possemato, Stefan Harry, Jay Miguel Fonticella, Lina Fellah, Drew Harrison, Maolin Ge, Neha Khandelwal, Yingfei Huang, Maëva Chauvin, Anica Tamara Bischof, Grace Marie Hambelton, Magdy Farag Gohar, Siwen Zhang, MinGyu Choi, Sara Bouberhan, Esther Oliva, Mari Mino-Kenudson, Natalya N. Pavlova, Michael Lawrence, Justin F. Gainor, Sean A. Beausoleil, Nabeel Bardeesy, Raul Mostoslavsky, David Pépin, Christopher J. Ott, Brian Liau, Liron Bar-Peled

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08756-ySystematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species (...)

Nature

Phosphate-enabled mechanochemical PFAS destruction for fluoride reuse

mercredi 26 mars 2025 par Long Yang, Zijun Chen, Christopher A. Goult, Thomas Schlatzer, Robert S. Paton, Véronique Gouverneur

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08698-5This study highlights a protocol that converts various perfluoroalkyl and polyfluoroalkyl substances (PFASs), including fluoroplastics, into valuable fluorochemicals through a solvent-free mechanochemical process, thereby (...)

Nature