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The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8⁺ T cells against cancer

mercredi 25 septembre 2024 par Bing Feng, Zhiliang Bai, Xiaolei Zhou, Yang Zhao, Yu-Qing Xie, Xinyi Huang, Yang Liu, Tom Enbar, Rongrong Li, Yi Wang, Min Gao, Lucia Bonati, Mei-Wen Peng, Weilin Li, Bo Tao, Mélanie Charmoy, Werner Held, J. Joseph Melenhorst, Rong Fan, Yugang Guo, Li Tang

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07962-4Fc–IL-4, a typical type 2 cytokine, reinvigorates exhausted CD8+ T cells in tumours, underscoring this fusion protein as a potent immunotherapy that synergizes effectively with type 1 immunity against (...)

Nature

Nitrogen-doped amorphous monolayer carbon

mercredi 25 septembre 2024 par Xiuhui Bai, Pengfei Hu, Ang Li, Youwei Zhang, Aowen Li, Guangjie Zhang, Yufeng Xue, Tianxing Jiang, Zezhou Wang, Hanke Cui, Jianxin Kang, Hewei Zhao, Lin Gu, Wu Zhou, Li-Min Liu, Xiaohui Qiu, Lin Guo

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07958-0Free-standing nitrogen-doped amorphous monolayer carbon consisting of mixed five-, six- and seven-membered rings was prepared through the polymerization of pyrrole within the confined interlayer cavity of a removable (...)

Nature

Phages reconstitute NAD⁺ to counter bacterial immunity

mercredi 25 septembre 2024 par Ilya Osterman, Hadar Samra, Francois Rousset, Elena Loseva, Maxim Itkin, Sergey Malitsky, Erez Yirmiya, Adi Millman, Rotem Sorek

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07986-wA study shows that many phages are capable of evading antiphage defence systems of bacteria by reconstituting NAD+ from its degradation products in infected (...)

Nature

Single-cell multi-omics map of human fetal blood in Down syndrome

mercredi 25 septembre 2024 par Andrew R. Marderstein, Marco De Zuani, Rebecca Moeller, Jon Bezney, Evin M. Padhi, Shuo Wong, Tim H. H. Coorens, Yilin Xie, Haoliang Xue, Stephen B. Montgomery, Ana Cvejic

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07946-4Using single-cell and multi-omics data of fetal blood, a high-resolution molecular map of dysregulated haematopoiesis in Down syndrome is provided.

Nature

Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

mercredi 25 septembre 2024 par Zhiliang Bai, Bing Feng, Susan E. McClory, Beatriz Coutinho de Oliveira, Caroline Diorio, Céline Gregoire, Bo Tao, Luojia Yang, Ziran Zhao, Lei Peng, Giacomo Sferruzza, Liqun Zhou, Xiaolei Zhou, Jessica Kerr, Alev Baysoy, Graham Su, Mingyu Yang, Pablo G. Camara, Sidi Chen, Li Tang, Carl H. June, J. Joseph Melenhorst, Stephan A. Grupp, Rong Fan

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07762-wElevated type 2 functionality in CAR T cell infusion products is significantly associated with maintenance of a median B cell aplasia duration of 8.4 years in paediatric patients with acute lymphocytic (...)

Nature

Direct evidence for a carbon–carbon one-electron ?-bond

mercredi 25 septembre 2024 par Takuya Shimajiri, Soki Kawaguchi, Takanori Suzuki, Yusuke Ishigaki

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07965-1The one-electron oxidation of a hydrocarbon with an elongated C–C single bond provides direct evidence for a one-electron σ-bond between carbon atoms.

Nature

Structural basis of archaeal FttA-dependent transcription termination

mercredi 25 septembre 2024 par Linlin You, Chengyuan Wang, Vadim Molodtsov, Konstantin Kuznedelov, Xinyi Miao, Breanna R. Wenck, Paul Ulisse, Travis J. Sanders, Craig J. Marshall, Emre Firlar, Jason T. Kaelber, Thomas J. Santangelo, Richard H. Ebright

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07979-9Cryo-electron microscopy structures of the Thermococcus kodakarensis transcription pre-termination complex suggest a mechanism by which the archaeal termination factor FttA applies mechanical force to a transcription (...)

Nature

Childhood leukaemia in Down’s syndrome primed by blood-cell bias

mercredi 25 septembre 2024 par Sébastien Malinge

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-02785-9An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing (...)

Nature

Non-invasive optogenetic stimulation of distinct stress responses in plants

mercredi 25 septembre 2024

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-03085-yTwo ion channels (structures in cell membranes that allow ions to pass through) have been genetically engineered to reveal the stress responses of plants non-invasively. When triggered by light, one channel provoked (...)

Nature

A jaw-dropping discovery about early mammals

mercredi 25 septembre 2024 par Zhe-Xi Luo

Nature, Published online: 25 September 2024; doi:10.1038/d41586-024-03038-5Mammals feed using a jaw hinge formed by dentary and squamosal bones. Fossil evidence reveals that this type of joint evolved independently in an extinct species of mammalian relatives called (...)

Nature