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Engineered prime editors with minimal genomic errors

mercredi 17 septembre 2025 par Vikash P. Chauhan, Phillip A. Sharp, Robert Langer

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09537-3Engineered prime editor systems with reduced occurrences of unwanted insertions or deletions during genome editing are developed.

Nature

Repeated head trauma causes neuron loss and inflammation in young athletes

mercredi 17 septembre 2025 par Morgane L. M. D. Butler, Nida Pervaiz, Kerry Breen, Samantha Calderazzo, Petra Ypsilantis, Yichen Wang, Julia Cammasola Breda, Sarah Mazzilli, Raymond Nicks, Elizabeth Spurlock, Marco M. Hefti, Kimberly L. Fiock, Bertrand R. Huber, Victor E. Alvarez, Thor D. Stein, Joshua D. Campbell, Ann C. McKee, Jonathan D. Cherry

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09534-6Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau (...)

Nature

Analogue speech recognition based on physical computing

mercredi 17 septembre 2025 par Mohamadreza Zolfagharinejad, Julian Büchel, Lorenzo Cassola, Sachin Kinge, Ghazi Sarwat Syed, Abu Sebastian, Wilfred G. van der Wiel

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09501-1A temporal-signal processor based on two in-materia computing hardware platforms—reconfigurable nonlinear-processing units (RNPUs) and analogue in-memory computing (AIMC)—is used for both feature extraction and (...)

Nature

CRISPR activation for SCN2A-related neurodevelopmental disorders

mercredi 17 septembre 2025 par Serena Tamura, Andrew D. Nelson, Perry W. E. Spratt, Elizabeth C. Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S. Holden, Atehsa Sahagun, Caroline M. Keeshen, Congyi Lu, Roy Ben-Shalom, Sunrae E. Taloma, Selin Schamiloglu, Ying C. Li, Lia Min, Paul M. Jenkins, Jen Q. Pan, Jeanne T. Paz, Stephan J. Sanders, Navneet Matharu, Nadav Ahituv, Kevin J. Bender

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09522-wUsing SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploinsufficient mice and (...)

Nature

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

mercredi 17 septembre 2025 par Abbie S. Ireland, Daniel A. Xie, Sarah B. Hawgood, Margaret W. Barbier, Lisa Y. Zuo, Benjamin E. Hanna, Scarlett Lucas-Randolph, Darren R. Tyson, Benjamin L. Witt, Ramaswamy Govindan, Afshin Dowlati, Justin C. Moser, Anish Thomas, Sonam Puri, Charles M. Rudin, Joseph M. Chan, Andrew Elliott, Trudy G. Oliver

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09503-zBasal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new (...)

Nature

New Hope in Alzheimer’s Research

mercredi 17 septembre 2025 par Lauren Gravitz

Nature, Published online: 17 September 2025; doi:10.1038/d41586-025-02924-wBreakthrough therapies, new diagnostics and preventive measures for fighting a devastating disease.

Nature

This AI tool predicts your risk of 1,000 diseases — by looking at your medical records

mercredi 17 septembre 2025 par Shamini Bundell, Nick Petri? Howe

Nature, Published online: 17 September 2025; doi:10.1038/d41586-025-03026-3Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat.

Nature

A neuronal architecture underlying autonomic dysreflexia

mercredi 17 septembre 2025 par Jan Elaine Soriano, Remi Hudelle, Lois Mahe, Matthieu Gautier, Alan Yue Yang Teo, Michael A. Skinnider, Achilleas Laskaratos, Steven Ceto, Claudia Kathe, Thomas Hutson, Rebecca Charbonneau, Fady Girgis, Steve Casha, Julien Rimok, Marcus Tso, Kelly Larkin-Kaiser, Nicolas Hankov, Aasta Gandhi, Suje Amir, Xiaoyang Kang, Yashwanth Vyza, Eduardo Martin-Moraud, Stephanie Lacour, Robin Demesmaeker, Leonie Asboth, Quentin Barraud, Mark A. Anderson, Jocelyne Bloch, Jordan W. Squair, Aaron A. Phillips, Gregoire Courtine

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09487-wThe neuronal architecture that develops after spinal cord injury and causes autonomic dysreflexia is uncovered.

Nature

A plant-forward menu is linked to lower diabetes risk

mercredi 17 septembre 2025

Nature, Published online: 17 September 2025; doi:10.1038/d41586-025-02992-yRegimens that sideline animal products are associated with both environmental and health benefits, according to study of nearly 24,000 people.

Nature

AI is helping to decode animals’ speech. Will it also let us talk with them?

mercredi 17 septembre 2025 par Rachel Fieldhouse

Nature, Published online: 17 September 2025; doi:10.1038/d41586-025-02917-9The complexity of vocal communication in some primates, whales and birds might approach that of human language.

Nature