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Designing allosteric modulators to change GPCR G protein subtype selectivity

mercredi 22 octobre 2025 par Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Lawrence S. Barak, Ezequiel Marron Fernandez de Velasco, Steven H. Olson, Lauren M. Slosky

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09643-2Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor subtype (...)

Nature

Transcriptional interferences ensure one olfactory receptor per ant neuron

mercredi 22 octobre 2025 par Bogdan Sieriebriennikov, Olena Kolumba, Aurore de Beaurepaire, Jennifer Wu, Valentina Fambri, Eva Bardol, Yuwei Zhong, Ildar Gainetdinov, Danny Reinberg, Hua Yan, Claude Desplan

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09664-xAnts evolved a transcriptional-interference-based mechanism to express a single odorant receptor from an array of Or genes with functionally similar promoters.

Nature

A circular economy approach for the global lithium-ion battery supply chain

mercredi 22 octobre 2025 par Mengyu Zhai, Yufeng Wu, Shaonan Tian, Haoran Yuan, Bin Li, Xubiao Luo, Guohe Huang, Yupeng Fu, Mengye Zhu, Yifan Gu, Wei Huan, Yu Dai, Huaidong Wang, Liming Yang, Xiaofei Yin, Gongqi Liu, Zhi Li, Jing Gu, Yazhuo Wang, Yong Chen, Tieyong Zuo

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09617-4A circular economy approach applied to the global lithium-ion battery supply chain shows that combining cross-regional cooperation on technology and trade with regionally tailored domestic circular economy policies yields (...)

Nature

Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

mercredi 22 octobre 2025 par Sanjeev S. Ranade, Feiya Li, Sean Whalen, Angelo Pelonero, Lin Ye, Yu Huang, Abigail Brand, Tomohiro Nishino, Rahul Mital, Ryan M. Boileau, Frances Koback, Arun Padmanabhan, Victoria Yu, Bastien Cimarosti, Diana Presas-Ramos, Alexander F. Merriman, Langley Grace Wallace, Annie Nguyen, Nikolaos Poulis, Mauro W. Costa, Casey A. Gifford, Katherine S. Pollard, Deepak Srivastava

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09593-9Studies using human pluripotent stem cells and a mouse model of Down syndrome identify HMGN1 as a key contributor to congenital heart defects in individuals with Down (...)

Nature

A metallic p-wave magnet with commensurate spin helix

mercredi 22 octobre 2025 par Rinsuke Yamada, Max T. Birch, Priya R. Baral, Shun Okumura, Ryota Nakano, Shang Gao, Motohiko Ezawa, Takuya Nomoto, Jan Masell, Yuki Ishihara, Kamil K. Kolincio, Ilya Belopolski, Hajime Sagayama, Hironori Nakao, Kazuki Ohishi, Takashi Ohhara, Ryoji Kiyanagi, Taro Nakajima, Yoshinori Tokura, Taka-hisa Arima, Yukitoshi Motome, Moritz M. Hirschmann, Max Hirschberger

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09633-4A metallic p-wave magnet with commensurate spin helix and anisotropic electronic properties is experimentally realized and shows a giant anomalous Hall effect when distorted by a tiny spontaneous (...)

Nature

Oxidative potential of atmospheric particles in Europe and exposure scenarios

mercredi 22 octobre 2025 par Cécile Tassel, Jean-Luc Jaffrezo, Pamela Dominutti, Kaspar R. Daellenbach, Sophie Darfeuil, Rhabira Elazzouzi, Paolo Laj, Anouk Marsal, Takoua Mhadhbi, Vy Ngoc Thuy Dinh, Céline Voiron, Stephan Houdier, Marc Durif, Mélodie Chatain, Florie Francony, Julie Cozic, Guillaume Salque Moreton, Meryll Le Quilleuc, Véronique Ghersi, Grégory Gille, Boualem Mesbah, Evdokia Stratigou, Manuela Zublena, Henri Diémoz, Andrés Alastuey, Barbara D’Anna, Nicolas Marchand, Sébastien Conil, Valérie Gros, Marloes F. van Os, Imre Salma, Nikolaos Mihalopoulos, Griša Mo?nik, Katja Džepina, Katarzyna Styszko, Christoph Hüglin, Xavier Querol, André S. H. Prévôt, Olivier Favez, Valérie Siroux, Gaëlle Uzu

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09666-9Extensive oxidative potential measurements from across Europe analysed with the two most common assays, dithiothreitol and ascorbic acid, using a standardized protocol show the strong influence of site type and suggest (...)

Nature

Deterministic soliton microcombs in Cu-free photonic integrated circuits

mercredi 22 octobre 2025 par Xinru Ji, Xurong Li, Zheru Qiu, Rui Ning Wang, Marta Divall, Andrey Gelash, Grigory Lihachev, Tobias J. Kippenberg

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09598-4Copper-impurity-free Si3N4 photonic integrated circuits reduce thermal absorption and enable robust, deterministic soliton generation.

Nature

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

mercredi 22 octobre 2025 par Giovanni Luchetti, Marin V. Miner, Rachael M. Peterson, William P. Scott, Praveen Krishnamoorthy, Eric M. Kofoed, Angel G. Jimenez, Hua Zhang, Man Wah Tan, Rohit Reja, Tommy K. Cheung, Elizabeth Skippington, Yuxin Liang, Christopher M. Rose, Nobuhiko Kayagaki, Kim Newton, Isabella Rauch, Vishva M. Dixit

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09645-0The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled in the (...)

Nature

Optimization by decoded quantum interferometry

mercredi 22 octobre 2025 par Stephen P. Jordan, Noah Shutty, Mary Wootters, Adam Zalcman, Alexander Schmidhuber, Robbie King, Sergei V. Isakov, Tanuj Khattar, Ryan Babbush

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09527-5Decoded quantum interferometry is a quantum algorithm that uses the quantum Fourier transform to reduce optimization problems to decoding problems.

Nature

Classical theories of gravity produce entanglement

mercredi 22 octobre 2025 par Joseph Aziz, Richard Howl

Nature, Published online: 22 October 2025; doi:10.1038/s41586-025-09595-7By applying the full framework of quantum field theory, it is shown that local classical theories of gravity can transmit quantum information and, thus, generate entanglement through physical, local (...)

Nature