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Thermal Ca²⁺/Mg²⁺ exchange reactions to synthesize CO₂ removal materials

mercredi 19 février 2025 par Yuxuan Chen, Matthew W. Kanan

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08499-2Reactions of Mg-rich silicates with calcium carbonates/sulfates result in the formation of materials that could potentially be used for low-cost carbon dioxide removal from the (...)

Nature

Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis

mercredi 19 février 2025 par Xiaofei Zhi, Feijing Wu, Jin Qian, Yosuke Ochiai, Guodong Lian, Ermanno Malagola, Biyun Zheng, Ruhong Tu, Yi Zeng, Hiroki Kobayashi, Zhangchuan Xia, Ruizhi Wang, Yueqing Peng, Qiongyu Shi, Duan Chen, Sandra W. Ryeom, Timothy C. Wang

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08591-1Functional connectivity between gastric cancer cells and sensory neurons offers a potential therapeutic target.

Nature

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

mercredi 19 février 2025 par Tara Barron, Belgin Yalç?n, Minhui Su, Youkyeong Gloria Byun, Avishai Gavish, Kiarash Shamardani, Haojun Xu, Lijun Ni, Neeraj Soni, Vilina Mehta, Samin Maleki Jahan, Yoon Seok Kim, Kathryn R. Taylor, Michael B. Keough, Michael A. Quezada, Anna C. Geraghty, Rebecca Mancusi, Linh Thuy Vo, Enrique Herrera Castañeda, Pamelyn J. Woo, Claudia K. Petritsch, Hannes Vogel, Kai Kaila, Michelle Monje

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08579-3Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.

Nature

De novo design of transmembrane fluorescence-activating proteins

mercredi 19 février 2025 par Jingyi Zhu, Mingfu Liang, Ke Sun, Yu Wei, Ruiying Guo, Lijing Zhang, Junhui Shi, Dan Ma, Qi Hu, Gaoxingyu Huang, Peilong Lu

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08598-8A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.

Nature

Newfound bat virus that uses notorious receptor poses ‘spillover’ risk

mercredi 19 février 2025

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00503-7The virus is related to the pathogen that causes Middle East respiratory syndrome and capitalizes on the same ‘entry receptor’ used by SARS-CoV-2.

Nature

World and Human Action Models towards gameplay ideation

mercredi 19 février 2025 par Anssi Kanervisto, Dave Bignell, Linda Yilin Wen, Martin Grayson, Raluca Georgescu, Sergio Valcarcel Macua, Shan Zheng Tan, Tabish Rashid, Tim Pearce, Yuhan Cao, Abdelhak Lemkhenter, Chentian Jiang, Gavin Costello, Gunshi Gupta, Marko Tot, Shu Ishida, Tarun Gupta, Udit Arora, Ryen W. White, Sam Devlin, Cecily Morrison, Katja Hofmann

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08600-3A state-of-the-art generative artificial intelligence model of a video game is introduced to allow the support of human creative ideation, with the analysis of user study data highlighting three necessary capabilities, (...)

Nature

Mechanism for local attenuation of DNA replication at double-strand breaks

mercredi 19 février 2025 par Robin Sebastian, Eric G. Sun, Michael Fedkenheuer, Haiqing Fu, SeolKyoung Jung, Bhushan L. Thakur, Christophe E. Redon, Gianluca Pegoraro, Andy D. Tran, Jacob M. Gross, Sara Mosavarpour, Nana Afua Kusi, Anagh Ray, Anjali Dhall, Lorinc S. Pongor, Rafael Casellas, Mirit I. Aladjem

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08557-9DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA (...)

Nature

RNA neoantigen vaccines prime long-lived CD8⁺ T cells in pancreatic cancer

mercredi 19 février 2025 par Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson, Jayon Lihm, George Payne, Olga Lyudovyk, Luis A. Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M. Bruno, Siqi Linsey Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yadav, Taha Merghoub, Jedd D. Wolchok, Olca Basturk, Mithat Gönen, Andrew S. Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M. Varghese, Elizabeth Won, Avni Desai, Alice C. Wei, Michael I. D’Angelica, T. Peter Kingham, Kevin C. Soares, William R. Jarnagin, Jeffrey Drebin, Eileen M. O’Reilly, Ira Mellman, Ugur Sahin, Özlem Türeci, Benjamin D. Greenbaum, Vinod P. Balachandran

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08508-4In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of (...)

Nature

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures

mercredi 19 février 2025 par Maise Al Bakir, James L. Reading, Samuel Gamble, Rachel Rosenthal, Imran Uddin, Andrew Rowan, Joanna Przewrocka, Amber Rogers, Yien Ning Sophia Wong, Amalie K. Bentzen, Selvaraju Veeriah, Sophia Ward, Aaron T. Garnett, Paula Kalavakur, Carlos Martínez-Ruiz, Clare Puttick, Ariana Huebner, Daniel E. Cook, David A. Moore, Chris Abbosh, Crispin T. Hiley, Cristina Naceur-Lombardelli, Thomas B. K. Watkins, Marina Petkovic, Roland F. Schwarz, Felipe Gálvez-Cancino, Kevin Litchfield, Peter Meldgaard, Boe Sandahl Sorensen, Line Bille Madsen, Dirk Jäger, Martin D. Forster, Tobias Arkenau, Clara Domingo-Vila, Timothy I. M. Tree, Mohammad Kadivar, Sine Reker Hadrup, Benny Chain, Sergio A. Quezada, Nicholas McGranahan, Charles Swanton

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08586-yWe show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 (...)

Nature