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Mathematician who reshaped theory of symmetry wins Abel Prize

mercredi 26 mars 2025 par Davide Castelvecchi

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00949-9Masaki Kashiwara is the first Japanese person to be awarded the most prestigious prize in mathematics.

Nature

Certified randomness using a trapped-ion quantum processor

mercredi 26 mars 2025 par Minzhao Liu, Ruslan Shaydulin, Pradeep Niroula, Matthew DeCross, Shih-Han Hung, Wen Yu Kon, Enrique Cervero-Martín, Kaushik Chakraborty, Omar Amer, Scott Aaronson, Atithi Acharya, Yuri Alexeev, K. Jordan Berg, Shouvanik Chakrabarti, Florian J. Curchod, Joan M. Dreiling, Neal Erickson, Cameron Foltz, Michael Foss-Feig, David Hayes, Travis S. Humble, Niraj Kumar, Jeffrey Larson, Danylo Lykov, Michael Mills, Steven A. Moses, Brian Neyenhuis, Shaltiel Eloul, Peter Siegfried, James Walker, Charles Lim, Marco Pistoia

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08737-1Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.

Nature

The other climate crisis

mercredi 26 mars 2025 par Tiffany A. Shaw, Bjorn Stevens

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08680-1The standard approach of climate science is showing signs of a crisis owing to the emergence of discrepancies and disruptions in recent years; this Perspective discusses the policy implications and the paths (...)

Nature

STING agonist-based ER-targeting molecules boost antigen cross-presentation

mercredi 26 mars 2025 par Xiafeng Wang, Zhangping Huang, Lixiao Xing, Liru Shang, Juan Jiang, Caiguanxi Deng, Wei Yu, Lin Peng, Hao Yang, Xiaohong Zheng, Xinmin Liu, Haolan Yang, Yixin Chen, Yongyong Li, Jing Liu, Xi Xie, Wei Xu, Xiaojun Xia, Zezhong Liu, Wanli Liu, Shibo Jiang, Yingyue Zeng, Lu Lu, Ji Wang

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08758-wSTING agonist-based endoplasmic reticulum-targeting molecules can be conjugated directly onto antigens to deliver them to the cross-presentation pathway, improving CD8+ T cell responses against tumours and (...)

Nature

Witnessing the onset of reionization through Lyman-? emission at redshift 13

mercredi 26 mars 2025 par Joris Witstok, Peter Jakobsen, Roberto Maiolino, Jakob M. Helton, Benjamin D. Johnson, Brant E. Robertson, Sandro Tacchella, Alex J. Cameron, Renske Smit, Andrew J. Bunker, Aayush Saxena, Fengwu Sun, Stacey Alberts, Santiago Arribas, William M. Baker, Rachana Bhatawdekar, Kristan Boyett, Phillip A. Cargile, Stefano Carniani, Stéphane Charlot, Jacopo Chevallard, Mirko Curti, Emma Curtis-Lake, Francesco D’Eugenio, Daniel J. Eisenstein, Kevin N. Hainline, Gareth C. Jones, Nimisha Kumari, Michael V. Maseda, Pablo G. Pérez-González, Pierluigi Rinaldi, Jan Scholtz, Hannah Übler, Christina C. Williams, Christopher N. A. Willmer, Chris Willott, Yongda Zhu

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08779-5Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big (...)

Nature

Multimodal generative AI for medical image interpretation

mercredi 26 mars 2025 par Vishwanatha M. Rao, Michael Hla, Michael Moor, Subathra Adithan, Stephen Kwak, Eric J. Topol, Pranav Rajpurkar

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08675-yThis Perspective describes how recent advances in artificial intelligence could be used to automate medical image interpretation to complement human expertise and empower physicians and (...)

Nature

Connectome-driven neural inventory of a complete visual system

mercredi 26 mars 2025 par Aljoscha Nern, Frank Loesche, Shin-ya Takemura, Laura E. Burnett, Marisa Dreher, Eyal Gruntman, Judith Hoeller, Gary B. Huang, Micha? Januszewski, Nathan C. Klapoetke, Sanna Koskela, Kit D. Longden, Zhiyuan Lu, Stephan Preibisch, Wei Qiu, Edward M. Rogers, Pavithraa Seenivasan, Arthur Zhao, John Bogovic, Brandon S. Canino, Jody Clements, Michael Cook, Samantha Finley-May, Miriam A. Flynn, Imran Hameed, Alexandra M. C. Fragniere, Kenneth J. Hayworth, Gary Patrick Hopkins, Philip M. Hubbard, William T. Katz, Julie Kovalyak, Shirley A. Lauchie, Meghan Leonard, Alanna Lohff, Charli A. Maldonado, Caroline Mooney, Nneoma Okeoma, Donald J. Olbris, Christopher Ordish, Tyler Paterson, Emily M. Phillips, Tobias Pietzsch, Jennifer Rivas Salinas, Patricia K. Rivlin, Philipp Schlegel, Ashley L. Scott, Louis A. Scuderi, Satoko Takemura, Iris Talebi, Alexander Thomson, Eric T. Trautman, Lowell Umayam, Claire Walsh, John J. Walsh, C. Shan Xu, Emily A. Yakal, Tansy Yang, Ting Zhao, Jan Funke, Reed George, Harald F. Hess, Gregory S. X. E. Jefferis, Christopher Knecht, Wyatt Korff, Stephen M. Plaza, Sandro Romani, Stephan Saalfeld, Louis K. Scheffer, Stuart Berg, Gerald M. Rubin, Michael B. Reiser

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08746-0A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type (...)

Nature

A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein

mercredi 26 mars 2025 par Ellen Van Damme, Pravien Abeywickrema, Yanting Yin, Jiexiong Xie, Sofie Jacobs, Mandeep Kaur Mann, Jordi Doijen, Robyn Miller, Madison Piassek, Simone Marsili, Murali Subramanian, Leah Gottlieb, Rana Abdelnabi, Michiel Van Gool, Nick Van den Broeck, Ines De Pauw, Annick Diels, Peter Vermeulen, Koen Temmerman, Trevor Scobey, Melissa Mattocks, Alexandra Schäfer, Dirk Jochmans, Steven De Jonghe, Pieter Leyssen, Winston Chiu, Mayra Diosa Toro, Marleen Zwaagstra, Anouk A. Leijs, Heidi L. M. De Gruyter, Christophe Buyck, Klaas Van Den Heede, Frank Jacobs, Christel Van den Eynde, Laura Thijs, Valerie Raeymaekers, Seth Miller, Amanda Del Rosario, Johan Neyts, Danielle Peeters, Ralph S. Baric, Frank J. M. van Kuppeveld, Eric J. Snijder, Martijn J. van Hemert, Mario Monshouwer, Sujata Sharma, Ruxandra Draghia-Akli, Anil Koul, Marnix Van Loock

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08651-6JNJ-9676—a small-molecule inhibitor targeting coronavirus M protein that shows excellent efficacy in Syrian golden hamster models—binds to and stabilizes the M protein dimer in an altered conformational state between its long (...)

Nature

Catalytic allylation of native hexoses and pentoses in water with indium

mercredi 26 mars 2025 par Tapas Adak, Travis Menard, Matthew Albritton, Federico Florit, Martin D. Burke, Klavs F. Jensen, Scott E. Denmark

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08690-zA longstanding challenge in organic synthesis—the catalytic allylation of unprotected saccharides in an aqueous medium, a key step for the synthesis of Millad NX 8000—is achieved through a simple and efficient indium-catalysed (...)

Nature

Synaptic and neural behaviours in a standard silicon transistor

mercredi 26 mars 2025 par Sebastian Pazos, Kaichen Zhu, Marco A. Villena, Osamah Alharbi, Wenwen Zheng, Yaqing Shen, Yue Yuan, Yue Ping, Mario Lanza

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08742-4A standard commercial CMOS FET can exhibit synaptic-like long-term potentiation and depression or neuron-like leaky-integrate-and-fire and adaptive frequency-bursting behaviour when biased in a specific but unconventional (...)

Nature