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Endogenous DNA damage at sites of terminated transcripts

mercredi 19 février 2025 par Jingjing Liu, Jullian O. Perren, Cody M. Rogers, Sadeieh Nimer, Alice X. Wen, Jennifer A. Halliday, Devon M. Fitzgerald, Qian Mei, Ralf B. Nehring, Mary Crum, Stanislav G. Kozmin, Jun Xia, Matthew B. Cooke, Yin Zhai, David Bates, Lei Li, P. J. Hastings, Irina Artsimovitch, Christophe Herman, Patrick M. Sung, Kyle M. Miller, Susan M. Rosenberg

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08578-4Transcription termination or pausing during DNA replication in bacteria and humans results in DNA damage with exposed 3′ single-stranded DNA ends and mutations.

Nature

Low-iridium device speeds progress towards green hydrogen

mercredi 19 février 2025

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00504-6A catalyst that reduces usage of an expensive rare metal could help to make hydrogen fuel affordable.

Nature

Microsoft claims quantum-computing breakthrough — but some physicists are sceptical

mercredi 19 février 2025 par Davide Castelvecchi

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00527-zThe tech giant aims to make ‘topological’ quantum computers that will reach useful scales faster than competing technologies.

Nature

Hypotaxy of wafer-scale single-crystal transition metal dichalcogenides

mercredi 19 février 2025 par Donghoon Moon, Wonsik Lee, Chaesung Lim, Jinwoo Kim, Jiwoo Kim, Yeonjoon Jung, Hyun-Young Choi, Won Seok Choi, Hangyel Kim, Ji-Hwan Baek, Changheon Kim, Jaewoong Joo, Hyun-Geun Oh, Hajung Jang, Kenji Watanabe, Takashi Taniguchi, Sukang Bae, Jangyup Son, Huije Ryu, Junyoung Kwon, Hyeonsik Cheong, Jeong Woo Han, Hyejin Jang, Gwan-Hyoung Lee

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08492-9A new method ‘hypotaxy’ enables wafer-scale, single-crystal transition metal dichalcogenides growth directly on crystalline, lattice-mismatched and amorphous (...)

Nature

Microsoft builds AI that creates ‘impressive’ video-game worlds

mercredi 19 février 2025 par Jackson Ryan

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00508-2Developers wanted tools that generate gameplay sequences that adhere to game rules; they say an engine called WHAM delivers.

Nature

Peptides from abnormal RNA processing in cancer offer an immunotherapy target

mercredi 19 février 2025 par Al Charest

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00302-0Tumour cells often have problems processing messenger RNA. The finding that these splicing errors result in commonly expressed peptides that are recognized by immune cells offers a target for cancer (...)

Nature

Cycles

mercredi 19 février 2025 par Kevin Eric Paul

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00519-zThe way of things.

Nature

How chronic stress warps decision-making

mercredi 19 février 2025 par Traci Watson

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00502-8Nerve-cell ‘highways’ identified in mice suggest that stress pushes the brain towards rigid habit and away from thoughtful choices.

Nature

Racist ratings linger in five-star systems — a thumbs up could fix that

mercredi 19 février 2025 par Nick Petri? Howe, Shamini Bundell

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00529-xWhen an online platform changed the way customers rated workers, discrimination disappeared — plus, Nature investigates where the most retractions occur.

Nature

The secrets of static electricity are finally being revealed

mercredi 19 février 2025 par Daniel J. Lacks, Mamadou Sow

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00298-7The mechanism that causes static electricity to build up is a mystery. Experiments now reveal that materials ‘remember’ past contacts with each other — and this determines how electric charge is transferred in future (...)

Nature