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A molecularly impermeable polymer from two-dimensional polyaramids

mercredi 12 novembre 2025 par Cody L. Ritt, Michelle Quien, Zitang Wei, Hagen Gress, Mohan T. Dronadula, Kaan Altmisdort, Huong Giang T. Nguyen, Christopher D. Zangmeister, Yu-Ming Tu, Sanjay S. Garimella, Shahab Amirabadi, Michael Gadaloff, Weiguo Hu, Narayana R. Aluru, Kamil L. Ekinci, J. Scott Bunch, Michael S. Strano

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09674-9Two-dimensional polyaramid polymers are synthesized to form nanofilms that exhibit the lowest gas permeability of any polymer by orders of magnitude, despite lacking crystallinity, enabling molecular-scale nanomechanical (...)

Nature

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

mercredi 12 novembre 2025 par Yifan Zhang, Xiao Shen, Yuan Shen, Chao Wang, Chengping Yu, Jiangxue Han, Siyi Cao, Lin Qian, Miaolian Ma, Shijing Huang, Wenyu Wen, Miao Yin, Qun-Ying Lei

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09745-xAcetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistance, providing a metabolic (...)

Nature

Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis

mercredi 12 novembre 2025 par Omer Nadel, Rawad Hanna, Andrey Rozenberg, Dror Shitrit, Ran Tahan, Irena Pekarsky, Oded Béjà, Oded Kleifeld, Debbie Lindell

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09656-xViral NblA accelerates the cyanophage infection cycle, directs degradation of the host phycobilisome and other proteins, and reduces host photosynthetic light-harvesting (...)

Nature

Radio burst from a stellar coronal mass ejection

mercredi 12 novembre 2025 par J. R. Callingham, C. Tasse, R. Keers, R. D. Kavanagh, H. K. Vedantham, P. Zarka, S. Bellotti, P. I. Cristofari, S. Bloot, D. C. Konijn, M. J. Hardcastle, L. Lamy, E. K. Pass, B. J. S. Pope, H. Reid, H. J. A. Röttgering, T. W. Shimwell, P. Zucca

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09715-3An analogue to a type II burst from the early M dwarf StKM 1-1262 exhibits identical frequency, time and polarization properties to fundamental plasma emission from a solar type II (...)

Nature

Convergent genome evolution shaped the emergence of terrestrial animals

mercredi 12 novembre 2025 par Jialin Wei, Davide Pisani, Philip C. J. Donoghue, Marta Álvarez-Presas, Jordi Paps

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09722-4Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent (...)

Nature

GREGoR: accelerating genomics for rare diseases

mercredi 12 novembre 2025 par Moez Dawood, Ben Heavner, Marsha M. Wheeler, Rachel A. Ungar, Jonathan LoTempio, Laurens Wiel, Seth Berger, Jonathan A. Bernstein, Jessica X. Chong, Emmanuèle C. Délot, Evan E. Eichler, James R. Lupski, Ali Shojaie, Michael E. Talkowski, Alex H. Wagner, Chia-Lin Wei, Christopher Wellington, Matthew T. Wheeler, Aashish Adhikari, Kinga M. Bujakowska, Ali Crawford, Aimée Dudley, Kelly D. Farwell Hagman, Yang I. Li, Jill E. Moore, Aaron R. Quinlan, Bo Xia, S. Stephen Yi, Claudia M. B. Carvalho, Richard A. Gibbs, Casey A. Gifford, Susanne May, Danny E. Miller, Heidi L. Rehm, Kaitlin E. Samocha, Fritz J. Sedlazeck, Eric Vilain, Anne O’Donnell-Luria, Jennifer E. Posey, Lisa H. Chadwick, Michael J. Bamshad, Stephen B. Montgomery, Hatoon Al Ali, Elizabeth G. Atkinson, Sairam Behera, Shaghayegh T. Beheshti, Eric Boerwinkle, Tugce Bozkurt-Yozgatli, Daniel G. Calame, Ivan Chinn, Zeynep H. Coban-Akdemir, Karen J. Coveler, Zain Dardas, Harsha Doddapaneni, Haowei Du, Ruizhi Duan, Iman Egab, Jawid Fatih, Mira Gandhi, Brandon Garcia, Nikhita Gogate, Christopher M. Grochowski, Jianhong Hu, Minal Jamsandekar, Shalini N. Jhangiani, Angad Jolly, Parneet Kaur, Ahmed K. Saad, Jesse M. Levine, Richard A. Lewis, Yidan Li, Pengfei Liu, Medhat Mahmoud, Dana Marafi, Tadahiro Mitani, Chloe Munderloh, Donna Muzny, Sebastian Ochoa, Piyush Panchal, Shruti Pande, Davut Pehlivan, Archana Rai, Edgar Andres Rivera-Munoz, Aniko Sabo, Evette Scott, Vernon Reid Sutton, Kimberly Walker, Lauren Westerfield, Jiaoyang Xu, Bo Yuan, Xinchang Zheng, Siwaar Abouhala, K. D. Ahlquist, Mutaz Amin, Christina Austin-Tse, Samantha M. Baxter, Benjamin Blankenmeister, Philip M. Boone, Harrison Brand, Colleen Carlston, Celine de Esch, Stephanie DiTroia, Michael Duyzend, Vijay Ganesh, Kiran Garimella, Carmen Glaze, Emily Groopman, Sanna Gudmundsson, Stacey Hall, Yongqing Huang, Julia Klugherz, Katie Larsson, Arthur S. Lee, Gabrielle Lemire, Jialan Ma, Daniel MacArthur, Brian Mangilog, Daniel Marten, Eva Martinez, Olfa Messaoud, Chloe Mighton, Mariana Moyses, Ashana Neale, Emily O’Heir, Melanie C. O’Leary, Ikeoluwa Osei-Owusu, Lynn Pais, Alicia Pham, Lindsay Romo, Kathryn Russell, Monica Salani, Kaitlin Samocha, Alba Sanchis-Juan, Jillian Serrano, Gulalai Shah, Moriel Singer-Berk, Mugdha Singh, Hana Snow, Kayla Socarras, Sarah L. Stenton, Jui-Cheng Tai, Grace VanNoy, Ben Weisburd, Michael Wilson, Monica Wojcik, Isaac Wong, Rachita Yadav, Emily Alsentzer, Taylor M. Arriaga, Euan A. Ashley, Themistocles Assimes, Gill Bejerano, Devon Bonner, Denver Bradley, Jennefer Carter, Clarisa Chavez Martinez, Ziwei Chen, Salil Deshpande, Sara Emami, Ivy Evergreen, Page Goddard, John Gorzynski, William Greenleaf, Rodrigo Guarischi-Sousa, Caitlin Harrington, Sohaib Hassan, Tanner D. Jensen, David Jimenez-Morales, Christopher Jin, Aimee Juan, Jessica Kain, Laura Keehan, Anshul Kundaje, Soumya Kundu, Samuel Lancaster, Shruti Marwaha, Dena R. Matalon, Lauren Meador, Hector Rodrigo Mendez, Alexander Miller, Matthew B. Neu, Thuy-mi P. Nguyen, Jonathan Nguyen, Jeren D. Olsen, Evin M. Padhi, Paul Petrowski, Astaria D. Podesta, Elizabeth Porter, Wanqiong Qiao, Thomas Quertermous, Chloe M. Reuter, Oriane Rubio, Stuart A. Scott, Riya Sinha, Kevin S. Smith, Michael P. Snyder, Brigitte Stark, Suchitra Sudarshan, Raquel L. Summers, Christina G. Tise, Philip Tsao, Isabella Voutos, Juliana M. Walrod, Ziming Weng, Frank Wong, Yao Yang, Jiye Yu, Jimmy Zhen, Miguel Almalvez, Light Auriga, Rebekah Barrick, Sami Belhadj, Krista Bluske, Leandros Boukas, Andrea J. Cohen, Ya Cui, Ivan De Dios, Meghan Delaney, John Harting, Yun-Hua Hsiao, Rachid Karam, Charles Hadley King, Arthur Ko, Wei Li, Bojan Losic, Georgia Pitsava, Changrui Xiao, Kailyn Anderson, Peter Anderson, Sabrina Best, Elizabeth E. Blue, Kati J. Buckingham, Silvia Casadei, Yong-Han Hank Cheng, Colleen P. Davis, Sophia B. Gibson, William W. Gordon, Jonas Gustafson, William T. Harvey, Martha Horike-Pyne, Gail P. Jarvik, Annelise Y. Mah-Som, Colby T. Marvin, F. Kumara Mastrorosa, Sean R. McGee, Heather C. Mefford, Karynne Patterson, Matthew Richardson, Adriana E. Sedeño Cortés, Joshua D. Smith, Olivia M. Sommerland, Lea M. Starita, Andrew B. Stergachis, Elliott G. Swanson, Jeffrey Weiss, Qian Yi, Christina Zakarian, Miranda P. Zalusky, Emily Bonkowski, Sarah Conner, Matthew P. Conomos, Stephanie M. Gogarten, Sarah C. Nelson, Sheryl Payne, Jaime Prosser, Guanghao Qi, Adrienne M. Stilp, Catherine C. Tong, Quenna Wong, Sara Currin, Gabrielle C. Villard

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09613-8The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

Nature

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

mercredi 12 novembre 2025 par Fengxiang Wang, Cuiji Sun, Tianshu William Wu, Yuting Fu, Yujing Fan, Shuchang Zhao, Kaiyin Huang, Zijian Pan, Yang Lu, Jingrong Regina Han, Shikai Jia, Lizhou Zeng, Sheng Zhang, Ting Chen, Shaowei An, Shuang Susie Meng, Xun Guo, Weizhe Li, Heyuan Lian, Xiaoting Sun, Jin Hu, Chuanzhen Yang, Shan Feng, Pengfei Li, Liyuan Du, Xiaodong Liu, Kiryl D. Piatkevich, Yilong Zou

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09734-0Isotropic tissue magnification is integrated with matrix-assisted laser desorption/ionization mass spectrometry imaging to enable untargeted spatial proteomics at micrometre resolution and with high protein identification (...)

Nature

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

mercredi 12 novembre 2025 par Hyunjin Noh, Zeena Hashem, Elena Boms, Ayaz Najafov

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09741-1CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a therapeutic (...)

Nature

How much protein do you really need? What the science says

mercredi 12 novembre 2025 par Mariana Lenharo

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03632-1Fitness influencers promote super-high-protein diets, but studies show there’s only so much the body can use.

Nature

Extreme rainfall poses the biggest risk to Mumbai’s most vulnerable people

mercredi 12 novembre 2025 par Subimal Ghosh

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03453-2An assessment of death rates in India’s coastal megacity of Mumbai reveals the impact of rain, high tides and flooding. Climate change will probably exacerbate the (...)

Nature