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Snapshots of acyl carrier protein shuttling in human fatty acid synthase

jeudi 20 février 2025 par Kollin Schultz, Pedro Costa-Pinheiro, Lauren Gardner, Laura V. Pinheiro, Julio Ramirez-Solis, Sarah M. Gardner, Kathryn E. Wellen, Ronen Marmorstein

Nature, Published online: 20 February 2025; doi:10.1038/s41586-025-08587-xUsing cryo-electron microscopy, the structures of mammalian fatty acid synthase reveal how the acyl carrier protein dynamically shuttles intermediates between selected active (...)

Nature

Rare genetic disorder treated in womb for the first time

jeudi 20 février 2025 par Smriti Mallapaty

Nature, Published online: 20 February 2025; doi:10.1038/d41586-025-00534-0The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

Nature

Author Correction: The genetic origin of the Indo-Europeans

jeudi 20 février 2025 par Iosif Lazaridis, Nick Patterson, David Anthony, Leonid Vyazov, Romain Fournier, Harald Ringbauer, Iñigo Olalde, Alexander A. Khokhlov, Egor P. Kitov, Natalia I. Shishlina, Sorin C. Ailinc?i, Danila S. Agapov, Sergey A. Agapov, Elena Batieva, Baitanayev Bauyrzhan, Zsolt Bereczki, Alexandra Buzhilova, Piya Changmai, Andrey A. Chizhevsky, Ion Ciobanu, Mihai Constantinescu, Marietta Csányi, János Dani, Peter K. Dashkovskiy, Sándor Évinger, Anatoly Faifert, Pavel Flegontov, Alin Frînculeasa, M?d?lina N. Frînculeasa, Tamás Hajdu, Tom Higham, Pawe? Jarosz, Pavol Jelínek, Valeri I. Khartanovich, Eduard N. Kirginekov, Viktória Kiss, Alexandera Kitova, Alexeiy V. Kiyashko, Jovan Koledin, Arkady Korolev, Pavel Kosintsev, Gabriella Kulcsár, Pavel Kuznetsov, Rabadan Magomedov, Aslan M. Mamedov, Eszter Melis, Vyacheslav Moiseyev, Erika Molnár, Janet Monge, Octav Negrea, Nadezhda A. Nikolaeva, Mario Novak, Maria Ochir-Goryaeva, György Pálfi, Sergiu Popovici, Marina P. Rykun, Tatyana M. Savenkova, Vladimir P. Semibratov, Nikolai N. Seregin, Alena Šef?áková, Raikhan S. Mussayeva, Irina Shingiray, Vladimir N. Shirokov, Angela Simalcsik, Kendra Sirak, Konstantin N. Solodovnikov, Judit Tárnoki, Alexey A. Tishkin, Viktor Trifonov, Sergey Vasilyev, Ali Akbari, Esther S. Brielle, Kim Callan, Francesca Candilio, Olivia Cheronet, Elizabeth Curtis, Olga Flegontova, Lora Iliev, Aisling Kearns, Denise Keating, Ann Marie Lawson, Matthew Mah, Adam Micco, Megan Michel, Jonas Oppenheimer, Lijun Qiu, J. Noah Workman, Fatma Zalzala, Anna Szécsényi-Nagy, Pier Francesco Palamara, Swapan Mallick, Nadin Rohland, Ron Pinhasi, David Reich

Nature, Published online: 20 February 2025; doi:10.1038/s41586-025-08789-3Author Correction: The genetic origin of the Indo-Europeans

Nature

Structural dynamics of human fatty acid synthase in the condensing cycle

jeudi 20 février 2025 par Wooyoung Choi, Chengmin Li, Yifei Chen, Yongqiang Wang, Yifan Cheng

Nature, Published online: 20 February 2025; doi:10.1038/s41586-025-08782-wStructural dynamics of human fatty acid synthase in the condensing cycle

Nature

Daily briefing: First in-womb treatment for motor-neuron condition is a success

jeudi 20 février 2025 par Jacob Smith

Nature, Published online: 20 February 2025; doi:10.1038/d41586-025-00556-8A motor-neuron condition has been successfully treated in the womb. Plus, how has one month of Donald Trump’s second presidency affected science?

Nature

Daily briefing: Meet the scientists who edit Wikipedia

mercredi 19 février 2025 par Jacob Smith

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00535-zWhich universities top the retraction chart? Plus, meet the scientists editing Wikipedia in their spare time.

Nature

Endogenous DNA damage at sites of terminated transcripts

mercredi 19 février 2025 par Jingjing Liu, Jullian O. Perren, Cody M. Rogers, Sadeieh Nimer, Alice X. Wen, Jennifer A. Halliday, Devon M. Fitzgerald, Qian Mei, Ralf B. Nehring, Mary Crum, Stanislav G. Kozmin, Jun Xia, Matthew B. Cooke, Yin Zhai, David Bates, Lei Li, P. J. Hastings, Irina Artsimovitch, Christophe Herman, Patrick M. Sung, Kyle M. Miller, Susan M. Rosenberg

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08578-4Transcription termination or pausing during DNA replication in bacteria and humans results in DNA damage with exposed 3′ single-stranded DNA ends and mutations.

Nature

Low-iridium device speeds progress towards green hydrogen

mercredi 19 février 2025

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00504-6A catalyst that reduces usage of an expensive rare metal could help to make hydrogen fuel affordable.

Nature

Microsoft claims quantum-computing breakthrough — but some physicists are sceptical

mercredi 19 février 2025 par Davide Castelvecchi

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00527-zThe tech giant aims to make ‘topological’ quantum computers that will reach useful scales faster than competing technologies.

Nature

Hypotaxy of wafer-scale single-crystal transition metal dichalcogenides

mercredi 19 février 2025 par Donghoon Moon, Wonsik Lee, Chaesung Lim, Jinwoo Kim, Jiwoo Kim, Yeonjoon Jung, Hyun-Young Choi, Won Seok Choi, Hangyel Kim, Ji-Hwan Baek, Changheon Kim, Jaewoong Joo, Hyun-Geun Oh, Hajung Jang, Kenji Watanabe, Takashi Taniguchi, Sukang Bae, Jangyup Son, Huije Ryu, Junyoung Kwon, Hyeonsik Cheong, Jeong Woo Han, Hyejin Jang, Gwan-Hyoung Lee

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08492-9A new method ‘hypotaxy’ enables wafer-scale, single-crystal transition metal dichalcogenides growth directly on crystalline, lattice-mismatched and amorphous (...)

Nature