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Gut bacteria help mice to stay lean

mercredi 12 novembre 2025

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03661-wResearchers have identified a specific genus in the mouse microbiome that aids weight loss, providing another potential route to anti-obesity treatments.

Nature

First new type of malaria treatment in decades shows promise against drug resistance

mercredi 12 novembre 2025 par Mariana Lenharo

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03690-5If approved, GanLum could be available within a year and a half, according to maker.

Nature

Fossilized technology: Books in brief

mercredi 12 novembre 2025 par Andrew Robinson

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03702-4Andrew Robinson reviews five of the best science picks.

Nature

The future of ageing: science aims to deliver another leap in lifespan

mercredi 12 novembre 2025 par Simon Baker

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03523-5A wave of research into the biology of ageing is raising hopes of a longer life, but fundamental questions remain.

Nature

‘Godfather of AI’ becomes first person to hit one million citations

mercredi 12 novembre 2025 par Davide Castelvecchi

Nature, Published online: 12 November 2025; doi:10.1038/d41586-025-03681-6The milestone makes machine-learning trailblazer Yoshua Bengio the most cited researcher on Google Scholar.

Nature

Controlling pyramidal nitrogen chirality by asymmetric organocatalysis

mercredi 12 novembre 2025 par San Wu, Pengquan Chen, Meng Duan, Peng-Ying Jiang, Qingyang Zhou, Shao-Hua Xiang, K. N. Houk, Bin Tan

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09607-6An asymmetric organocatalysis strategy is used to control pyramidal nitrogen chirality and to synthesize the enantioselective N-chloroaziridines with a configurationally stable nitrogen stereogenic (...)

Nature

In situ structural mechanism of epothilone-B-induced CNS axon regeneration

mercredi 12 novembre 2025 par Satish Bodakuntla, Kenichiro Taira, Yurika Yamada, Pelayo Alvarez-Brecht, A. King Cada, Nirakar Basnet, Rui Zhang, Antonio Martinez-Sanchez, Christian Biertümpfel, Naoko Mizuno

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09654-zA combined cryo-electron tomography and cryo-electron microscopy pipeline was developed to inflict axonal damage and monitor the cellular response induced by epothilone B, revealing that microtubule polymerization at and (...)

Nature

Ecology and spread of the North American H5N1 epizootic

mercredi 12 novembre 2025 par Lambodhar Damodaran, Anna S. Jaeger, Louise H. Moncla

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09737-xThe panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primarily (...)

Nature

Estimation and mapping of the missing heritability of human phenotypes

mercredi 12 novembre 2025 par Pierrick Wainschtein, Yuanxiang Zhang, Jeremy Schwartzentruber, Irfahan Kassam, Julia Sidorenko, Petko P. Fiziev, Huanwei Wang, Jeremy McRae, Richard Border, Noah Zaitlen, Sriram Sankararaman, Michael E. Goddard, Jian Zeng, Peter M. Visscher, Kyle Kai-How Farh, Loic Yengo

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09720-6WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 complex traits and (...)

Nature

Spatial fibroblast niches define Crohn’s fistulae

mercredi 12 novembre 2025 par Colleen McGregor, Xiao Qin, Marta Jagielowicz, Tarun Gupta, Zinan Yin, Verena Lentsch, David Fawkner-Corbett, Vy Wien Lai, Paula Gomez Castro, Esther Bridges, Chloe Hyun-Jung Lee, Huei-Wen Chuang, Lei Deng, Anna Aulicino, Renuka Teague, Sorayya Moradi, Jun Sung Park, Jeongmin Woo, Kexin Xu, Ruchi Tandon, Nicole Cianci, Jan Bornschein, Ling-Pei Ho, Paulina Siejka-Zielinska, Zoe Christoforidou, Sarah Hill, Johannes Lehmann, Rhea Kujawa, Paola Vargas Gutierrez, Carol Cheng, Maria Greco, Katherine Baker, Mark Bignell, Bruce George, Eve Fryer, Michael Vieth, Agne Antanaviciute, Alison Simmons

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09744-ySpatial transcriptomic analysis of cells in intestinal fistulae of patients with Crohn’s disease reveals the existence of specialized fistula-associated cell states with distinct signalling profiles and extracellular (...)

Nature