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PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

mercredi 3 septembre 2025 par Alena Kozlova, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Stanislau Smirnou, Seul Kee Byeon, Christina Thapa, Xiaotong Sun, Kimberley Stephenson, Xiaojie Zhao, Brendan Jamison, Moorthi Ponnusamy, Xin He, Julie A. Schneider, Akhilesh Pandey, David A. Bennett, Zhiping P. Pang, Alan R. Sanders, Hugo J. Bellen, Gopal Thinakaran, Jubao Duan

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09486-xA PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.

Nature

Supervised learning in DNA neural networks

mercredi 3 septembre 2025 par Kevin M. Cherry, Lulu Qian

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09479-wDNA molecules can be programmed to autonomously carry out supervised learning in vitro, with the system learning to perform pattern classification from molecular examples of inputs and desired (...)

Nature

3D-printed micro ion trap technology for quantum information applications

mercredi 3 septembre 2025 par Shuqi Xu, Xiaoxing Xia, Qian Yu, Abhinav Parakh, Sumanta Khan, Eli Megidish, Bingran You, Boerge Hemmerling, Andrew Jayich, Kristin Beck, Juergen Biener, Hartmut Häffner

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09474-1High-resolution 3D printing technology making use of two-photon polymerization instead of traditional machining is described, allowing low-cost and scalable production of large arrays of high-quality 3D Paul (...)

Nature

Adaptive and context-aware volumetric printing

mercredi 3 septembre 2025 par Sammy Florczak, Gabriel Größbacher, Davide Ribezzi, Alessia Longoni, Marième Gueye, Estée Grandidier, Jos Malda, Riccardo Levato

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09436-7A new approach combining 3D imaging, computer vision and parametric modelling, named GRACE, is introduced, enabling adaptive and context-aware 3D printing of structures around features ranging from cellular to (...)

Nature

Training of physical neural networks

mercredi 3 septembre 2025 par Ali Momeni, Babak Rahmani, Benjamin Scellier, Logan G. Wright, Peter L. McMahon, Clara C. Wanjura, Yuhang Li, Anas Skalli, Natalia G. Berloff, Tatsuhiro Onodera, Ilker Oguz, Francesco Morichetti, Philipp del Hougne, Manuel Le Gallo, Abu Sebastian, Azalia Mirhoseini, Cheng Zhang, Danijela Markovi?, Daniel Brunner, Christophe Moser, Sylvain Gigan, Florian Marquardt, Aydogan Ozcan, Julie Grollier, Andrea J. Liu, Demetri Psaltis, Andrea Alù, Romain Fleury

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09384-2Methods to train physical neural networks, such as backpropagation-based and backpropagation-free approaches, are explored to allow scaling up of artificial intelligence models far beyond present small-scale laboratory (...)

Nature

A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2

mercredi 3 septembre 2025 par Benjamin Vollmer, Henriette Ebel, Renate Rees, Julia Nentwig, Thomas Mulvaney, Jürgen Schünemann, Jens Krull, Maya Topf, Dirk Görlich, Kay Grünewald

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09438-5A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and an attractive avenue (...)

Nature

Patterned invagination prevents mechanical instability during gastrulation

mercredi 3 septembre 2025 par Bruno C. Vellutini, Marina B. Cuenca, Abhijeet Krishna, Alicja Sza?apak, Carl D. Modes, Pavel Tomancak

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09480-3In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphogenetic innovations in (...)

Nature

Spatial joint profiling of DNA methylome and transcriptome in tissues

mercredi 3 septembre 2025 par Chin Nien Lee, Hongxiang Fu, Angelysia Cardilla, Wanding Zhou, Yanxiang Deng

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09478-xDNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription interact to shape cell identity and (...)

Nature

A circuit that integrates drive state and social contact to gate mating

mercredi 3 septembre 2025 par Lindsey D. Salay, Doris Y. Tsao, David J. Anderson

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09327-xAnalyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive (...)

Nature

Single-cell transcriptomic and genomic changes in the ageing human brain

mercredi 3 septembre 2025 par Ailsa M. Jeffries, Tianxiong Yu, Jennifer S. Ziegenfuss, Allie K. Tolles, Christina E. Baer, Cesar Bautista Sotelo, Yerin Kim, Zhiping Weng, Michael A. Lodato

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09435-8Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the (...)

Nature