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Structural basis of regulated N-glycosylation at the secretory translocon

mercredi 19 novembre 2025 par Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi, Robert J. Keenan

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09756-8The structural mechanism of a natively isolated GRP94 folding intermediate tethered to a CCDC134-bound translocon is described, revealing how the nascent chain remodels the translocon to control N-glycosylation by (...)

Nature

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples

mercredi 19 novembre 2025 par Sofía Ibáñez-Molero, Johanna Veldman, Juan Simon Nieto, Joleen J. H. Traets, Austin George, Kelly Hoefakker, Anita Karomi, Rolf Harkes, Bram van den Broek, Su Min Pack, Liselotte Tas, Nils L. Visser, Susan E. van Hal-van Veen, Paula Alóndiga-Mérida, Maartje Alkemade, Iris M. Seignette, Renaud Tissier, Marja Nieuwland, Martijn van Baalen, Joanna Po?niak, Erik Mul, Simon Tol, Sofia Stenqvist, Lisa M. Nilsson, Jonas A. Nilsson, John B. A. G. Haanen, Winan J. van Houdt, Daniel S. Peeper

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09754-wTumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical (...)

Nature

Semantic design of functional de novo genes from a genomic language model

mercredi 19 novembre 2025 par Aditi T. Merchant, Samuel H. King, Eric Nguyen, Brian L. Hie

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09749-7By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined activities, whose (...)

Nature

ZAK activation at the collided ribosome

mercredi 19 novembre 2025 par Vienna L. Huso, Shuangshuang Niu, Marco A. Catipovic, James A. Saba, Timo Denk, Eugene Park, Jingdong Cheng, Otto Berninghausen, Thomas Becker, Rachel Green, Roland Beckmann

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09772-8The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Nature

Prime editing-installed suppressor tRNAs for disease-agnostic genome editing

mercredi 19 novembre 2025 par Sarah E. Pierce, Steven Erwood, Keyede Oye, Meirui An, Nicholas Krasnow, Emily Zhang, Aditya Raguram, Davis Seelig, Mark J. Osborn, David R. Liu

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09732-2A new strategy that uses prime editing to convert an endogenous tRNA into a suppressor tRNA shows therapeutic potential for multiple genetic diseases that are caused by premature stop (...)

Nature

Connectivity underlying motor cortex activity during goal-directed behaviour

mercredi 19 novembre 2025 par Arseny Finkelstein, Kayvon Daie, Márton Rózsa, Ran Darshan, Karel Svoboda

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09758-6All-optical mapping of neural connectivity in motor cortex links network topology to network dynamics and computation underlying naturalistic goal-directed (...)

Nature

Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases

mercredi 19 novembre 2025 par Wei-Chun Chou, Zengli Guo, Hao Guo, Liang Chen, Ge Zhang, Kaixin Liang, Ling Xie, Xianming Tan, Sara A. Gibson, Elena Rampanelli, Yan Wang, Stephanie A. Montgomery, W. June Brickey, Meng Deng, Leslie Freeman, Song Zhang, Maureen A. Su, Xian Chen, Yisong Y. Wan, Jenny P.-Y. Ting

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09859-2Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases

Nature

Insulin cream offers needle-free option for diabetes

mercredi 19 novembre 2025 par Shamini Bundell, Nick Petri? Howe

Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03803-0Skin-permeable polymer shows promise at insulin delivery in animal experiments — plus, how the brain responds to unfamiliar languages.

Nature

The Asymmetric Synthesis of an Acyclic N-Stereogenic Amine

mercredi 19 novembre 2025 par Chendan Zhu, Sayantani Das, Marie Sophie Sterling, Nobuya Tsuji, Spencer J. Léger, Frank Neese, Chandra Kanta De, Benjamin List

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09905-zThe Asymmetric Synthesis of an Acyclic N-Stereogenic Amine

Nature

Author Correction: A metallic p-wave magnet with commensurate spin helix

mercredi 19 novembre 2025 par Rinsuke Yamada, Max T. Birch, Priya R. Baral, Shun Okumura, Ryota Nakano, Shang Gao, Motohiko Ezawa, Takuya Nomoto, Jan Masell, Yuki Ishihara, Kamil K. Kolincio, Ilya Belopolski, Hajime Sagayama, Hironori Nakao, Kazuki Ohishi, Takashi Ohhara, Ryoji Kiyanagi, Taro Nakajima, Yoshinori Tokura, Taka-hisa Arima, Yukitoshi Motome, Moritz M. Hirschmann, Max Hirschberger

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09861-8Author Correction: A metallic p-wave magnet with commensurate spin helix

Nature