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Plasticity of the mammalian integrated stress response

mercredi 26 mars 2025 par Chien-Wen Chen, David Papadopoli, Krzysztof J. Szkop, Bo-Jhih Guan, Mohammed Alzahrani, Jing Wu, Raul Jobava, Mais M. Asraf, Dawid Krokowski, Anastasios Vourekas, William C. Merrick, Anton A. Komar, Antonis E. Koromilas, Myriam Gorospe, Matthew J. Payea, Fangfang Wang, Benjamin L. L. Clayton, Paul J. Tesar, Ashleigh Schaffer, Alexander Miron, Ilya Bederman, Eckhard Jankowsky, Christine Vogel, Leoš Shivaya Valášek, Jonathan D. Dinman, Youwei Zhang, Boaz Tirosh, Ola Larsson, Ivan Topisirovic, Maria Hatzoglou

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08794-6A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic (...)

Nature

A coronavirus assembly inhibitor that targets the viral membrane protein

mercredi 26 mars 2025 par Manon Laporte, Dirk Jochmans, Dorothée Bardiot, Lowiese Desmarets, Oliver J. Debski-Antoniak, Giulia Mizzon, Rana Abdelnabi, Pieter Leyssen, Winston Chiu, Zhikuan Zhang, Norimichi Nomura, Sandro Boland, Umeharu Ohto, Yannick Stahl, Jurgen Wuyts, Steven De Jonghe, Annelies Stevaert, Martijn J. van Hemert, Brenda W. Bontes, Patrick Wanningen, G. J. Mirjam Groenewold, Aneta Zegar, Katarzyna Owczarek, Sanjata Joshi, Mohamed Koukni, Philippe Arzel, Hugo Klaassen, Jean-Christophe Vanherck, Ilse Vandecaetsbeek, Niels Cremers, Kim Donckers, Thibault Francken, Tina Van Buyten, Jasper Rymenants, Joost Schepers, Krzysztof Pyrc, Rolf Hilgenfeld, Jean Dubuisson, Berend-Jan Bosch, Frank Van Kuppeveld, Cecilia Eydoux, Etienne Decroly, Bruno Canard, Lieve Naesens, Birgit Weynand, Eric J. Snijder, Sandrine Belouzard, Toshiyuki Shimizu, Ralf Bartenschlager, Daniel L. Hurdiss, Arnaud Marchand, Patrick Chaltin, Johan Neyts

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08773-xHigh-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the (...)

Nature

Lasso-shaped molecule is a new type of broad-spectrum antibiotic

mercredi 26 mars 2025 par Lynn L. Silver

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00901-xA natural antibacterial molecule shows clinical promise. Its unusual binding site is on an excellent target: protein-synthesis machinery known as the ribosome.

Nature

Some assembly required

mercredi 26 mars 2025 par Russell Nichols

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00922-6The personal touch.

Nature

AI is transforming peer review — and many scientists are worried

mercredi 26 mars 2025 par Miryam Naddaf

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00894-7Artificial intelligence software is increasingly involved in reviewing papers, provoking interest and unease.

Nature

New antibiotic that kills drug-resistant bacteria discovered in technician’s garden

mercredi 26 mars 2025 par Smriti Mallapaty

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00945-zThe molecule targets bacteria in a way that other drugs don’t.

Nature

Neuronal receptors at body temperature reveal their gating mechanics

mercredi 26 mars 2025

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00865-yMost communication between neurons is mediated by the neurotransmitter glutamate. The finding that temperature influences how glutamate binds to neuronal receptor proteins to initiate signal transduction reveals the (...)

Nature

Crucial meeting: molecule helps vaccine to interact with killer T cells

mercredi 26 mars 2025 par John T. Wilson

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00900-yVaccines containing peptides called antigens are bad at stimulating key immune cells called killer T cells. A molecule now enables antigens to encounter these T (...)

Nature

A map of mitochondrial biology reveals the energy landscape of the human brain

mercredi 26 mars 2025

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00872-zMapping the density, molecular features and energy-transformation capacity of cell organelles called mitochondria in the brain reveals region- and cell-type-specific variability that tracks with evolutionary patterns. (...)

Nature

Track gender ratios in research to keep countries, institutions and publishers accountable

mercredi 26 mars 2025

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00891-wNature Index data reveal how countries and fields differ in gender equity in research.

Nature