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Reconstitution of SPO11-dependent double-strand break formation

mercredi 19 février 2025 par Zhi Zheng, Lyuqin Zheng, Meret Arter, Kaixian Liu, Shintaro Yamada, David Ontoso, Soonjoung Kim, Scott Keeney

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08601-2Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the regulation and mechanism (...)

Nature

In vitro reconstitution of meiotic DNA double-strand-break formation

mercredi 19 février 2025 par Xinzhe Tang, Zetao Hu, Jian Ding, Meixia Wu, Pin Guan, Yawei Song, Yue Yin, Wei Wu, Jinbiao Ma, Ying Huang, Ming-Han Tong

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08551-1The in vitro characterization of a key event in the early stages of meiosis—the induction of double-strand DNA breaks by the SPO11–TOP6BL complex—provides insight into the catalytic mechanism and evolution of (...)

Nature

Reply to: Insufficient evidence for natural selection associated with the Black Death

mercredi 19 février 2025 par Tauras P. Vilgalys, Jennifer Klunk, Christian E. Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I. Patino, Rebecca Redfern, Sharon N. DeWitte, Julia A. Gamble, Jesper L. Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F. Brinkworth, Dominique Missiakas, Guy A. Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N. Poinar, Luis B. Barreiro

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08497-4Reply to: Insufficient evidence for natural selection associated with the Black Death

Nature

SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro

mercredi 19 février 2025 par Cédric Oger, Corentin Claeys Bouuaert

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08574-8A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently attached to 5′ broken (...)

Nature

Global modules robustly emerge from local interactions and smooth gradients

mercredi 19 février 2025 par Mikail Khona, Sarthak Chandra, Ila Fiete

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08541-3The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.

Nature

Perovskite heteroepitaxy for high-efficiency and stable pure-red LEDs

mercredi 19 février 2025 par Keyu Wei, Tong Zhou, Yuanzhi Jiang, Changjiu Sun, Yulong Liu, Saisai Li, Siyu Liu, Xinliang Fu, Cejun Hu, Shun Tian, Yingguo Yang, Xuewen Fu, Najla AlMasoud, Saif M. H. Qaid, Mohammad Khaja Nazeeruddin, Hsien-Yi Hsu, Wen-Di Li, Ji Tae Kim, Run Long, Wei Zhang, Jun Chen, Mingjian Yuan

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08503-9A heteroepitaxial-strain-based strategy for enhancing the stability of perovskite quantum dots for spectrally narrow (pure) red LEDs is reported.

Nature

Modulated ringdown comb interferometry for sensing of highly complex gases

mercredi 19 février 2025 par Qizhong Liang, Apoorva Bisht, Andrew Scheck, Peter G. Schunemann, Jun Ye

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08534-2A new optical technique, modulated ringdown comb interferometry, is introduced for measuring the concentration of gas species in a complex sample and its efficacy demonstrated using exhaled human breath and ambient air in (...)

Nature

Interferometric single-shot parity measurement in InAs–Al hybrid devices

mercredi 19 février 2025 par Morteza Aghaee, Alejandro Alcaraz Ramirez, Zulfi Alam, Rizwan Ali, Mariusz Andrzejczuk, Andrey Antipov, Mikhail Astafev, Amin Barzegar, Bela Bauer, Jonathan Becker, Umesh Kumar Bhaskar, Alex Bocharov, Srini Boddapati, David Bohn, Jouri Bommer, Leo Bourdet, Arnaud Bousquet, Samuel Boutin, Lucas Casparis, Benjamin J. Chapman, Sohail Chatoor, Anna Wulff Christensen, Cassandra Chua, Patrick Codd, William Cole, Paul Cooper, Fabiano Corsetti, Ajuan Cui, Paolo Dalpasso, Juan Pablo Dehollain, Gijs de Lange, Michiel de Moor, Andreas Ekefjärd, Tareq El Dandachi, Juan Carlos Estrada Saldaña, Saeed Fallahi, Luca Galletti, Geoff Gardner, Deshan Govender, Flavio Griggio, Ruben Grigoryan, Sebastian Grijalva, Sergei Gronin, Jan Gukelberger, Marzie Hamdast, Firas Hamze, Esben Bork Hansen, Sebastian Heedt, Zahra Heidarnia, Jesús Herranz Zamorano, Samantha Ho, Laurens Holgaard, John Hornibrook, Jinnapat Indrapiromkul, Henrik Ingerslev, Lovro Ivancevic, Thomas Jensen, Jaspreet Jhoja, Jeffrey Jones, Konstantin V. Kalashnikov, Ray Kallaher, Rachpon Kalra, Farhad Karimi, Torsten Karzig, Evelyn King, Maren Elisabeth Kloster, Christina Knapp, Dariusz Kocon, Jonne V. Koski, Pasi Kostamo, Mahesh Kumar, Tom Laeven, Thorvald Larsen, Jason Lee, Kyunghoon Lee, Grant Leum, Kongyi Li, Tyler Lindemann, Matthew Looij, Julie Love, Marijn Lucas, Roman Lutchyn, Morten Hannibal Madsen, Nash Madulid, Albert Malmros, Michael Manfra, Devashish Mantri, Signe Brynold Markussen, Esteban Martinez, Marco Mattila, Robert McNeil, Antonio B. Mei, Ryan V. Mishmash, Gopakumar Mohandas, Christian Mollgaard, Trevor Morgan, George Moussa, Chetan Nayak, Jens Hedegaard Nielsen, Jens Munk Nielsen, William Hvidtfelt Padkar Nielsen, Bas Nijholt, Mike Nystrom, Eoin O’Farrell, Thomas Ohki, Keita Otani, Brian Paquelet Wütz, Sebastian Pauka, Karl Petersson, Luca Petit, Dima Pikulin, Guen Prawiroatmodjo, Frank Preiss, Eduardo Puchol Morejon, Mohana Rajpalke, Craig Ranta, Katrine Rasmussen, David Razmadze, Outi Reentila, David J. Reilly, Yuan Ren, Ken Reneris, Richard Rouse, Ivan Sadovskyy, Lauri Sainiemi, Irene Sanlorenzo, Emma Schmidgall, Cristina Sfiligoj, Mustafeez Bashir Shah, Kevin Simoes, Shilpi Singh, Sarat Sinha, Thomas Soerensen, Patrick Sohr, Tomas Stankevic, Lieuwe Stek, Eric Stuppard, Henri Suominen, Judith Suter, Sam Teicher, Nivetha Thiyagarajah, Raj Tholapi, Mason Thomas, Emily Toomey, Josh Tracy, Michelle Turley, Shivendra Upadhyay, Ivan Urban, Kevin Van Hoogdalem, David J. Van Woerkom, Dmitrii V. Viazmitinov, Dominik Vogel, John Watson, Alex Webster, Joseph Weston, Georg W. Winkler, Di Xu, Chung Kai Yang, Emrah Yucelen, Roland Zeisel, Guoji Zheng, Justin Zilke

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08445-2A device architecture based on indium arsenide–aluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error (...)

Nature

Thermal Ca²⁺/Mg²⁺ exchange reactions to synthesize CO₂ removal materials

mercredi 19 février 2025 par Yuxuan Chen, Matthew W. Kanan

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08499-2Reactions of Mg-rich silicates with calcium carbonates/sulfates result in the formation of materials that could potentially be used for low-cost carbon dioxide removal from the (...)

Nature

Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis

mercredi 19 février 2025 par Xiaofei Zhi, Feijing Wu, Jin Qian, Yosuke Ochiai, Guodong Lian, Ermanno Malagola, Biyun Zheng, Ruhong Tu, Yi Zeng, Hiroki Kobayashi, Zhangchuan Xia, Ruizhi Wang, Yueqing Peng, Qiongyu Shi, Duan Chen, Sandra W. Ryeom, Timothy C. Wang

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08591-1Functional connectivity between gastric cancer cells and sensory neurons offers a potential therapeutic target.

Nature