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Rare microbial relict sheds light on an ancient eukaryotic supergroup

mercredi 19 novembre 2025 par Marek Valt, Tomáš Pánek, Seda Mirzoyan, Alexander K. Tice, Robert E. Jones, Vít Dohnálek, Pavel Doležal, Ji?í Mikšátko, Johana Rotterová, Pavla Hrubá, Matthew W. Brown, Ivan ?epi?ka
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09750-0The discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic (...)

Genetic elements promote retention of extrachromosomal DNA in cancer cells

mercredi 19 novembre 2025 par Venkat Sankar, King L. Hung, Aditi Gnanasekar, Ivy Tsz-Lo Wong, Quanming Shi, Katerina Kraft, Matthew G. Jones, Britney Jiayu He, Xiaowei Yan, Julia A. Belk, Kevin J. Liu, Sangya Agarwal, Sean K. Wang, Anton G. Henssen, Paul S. Mischel, Howard Y. Chang
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09764-8A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing cells and persist (...)

Topological nodal i-wave superconductivity in PtBi2

mercredi 19 novembre 2025 par Susmita Changdar, Oleksandr Suvorov, Andrii Kuibarov, Setti Thirupathaiah, Grigory Shipunov, Saicharan Aswartham, Sabine Wurmehl, Iryna Kovalchuk, Klaus Koepernik, Carsten Timm, Bernd Büchner, Ion Cosma Fulga, Sergey Borisenko, Jeroen van den Brink
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09712-6Angle-resolved photoemission spectroscopy shows that Weyl semimetal PtBi2 harbours nodes in its superconducting gap, implying unconventional i-wave pairing (...)

Electro-generated excitons for tunable lanthanide electroluminescence

mercredi 19 novembre 2025 par Jing Tan, Peng Zhang, Xiaoqing Song, Chunmiao Han, Feng Wang, Jing Zhang, Chunbo Duan, Zhilong Zhang, Sanyang Han, Hui Xu, Xiaogang Liu
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09717-1The electroluminescence emitted from lanthanide fluoride nanocrystals functionalized with ligands is shown to be tunable, providing a method for exciton control in insulating nanocrystal systems and offering a pathway for (...)

Rewiring an olfactory circuit by altering cell-surface combinatorial code

mercredi 19 novembre 2025 par Cheng Lyu, Zhuoran Li, Chuanyun Xu, Jordan Kalai, Liqun Luo
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09769-3In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s (...)

Triplets electrically turn on insulating lanthanide-doped nanoparticles

mercredi 19 novembre 2025 par Zhongzheng Yu, Yunzhou Deng, Junzhi Ye, Lars van Turnhout, Tianjun Liu, Alasdair Tew, Rakesh Arul, Simon Dowland, Yuqi Sun, Xinjuan Li, Linjie Dai, Yang Lu, Caterina Ducati, Jeremy J. Baumberg, Richard H. Friend, Robert L. Z. Hoye, Akshay Rao
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09601-yTo turn on and obtain emission from lanthanide-doped insulating nanoparticles, an electrical excitation pathway coupling them to organic optical molecules to form nanohybrids is described, enabling tunable (...)

A skin-permeable polymer for non-invasive transdermal insulin delivery

mercredi 19 novembre 2025 par Qiuyu Wei, Zhi He, Zifan Li, Zhuxian Zhou, Ying Piao, Jianxiang Huang, Yu Geng, Runnan Zhang, Yaqi Fu, Jiayi Ye, Yue Yuan, Haoru Zhu, Jiaheng Zeng, Yan Zhang, Quan Zhou, Mingyu Xu, Shiqun Shao, Jianbin Tang, Jiajia Xiang, Rongjun Chen, Ruhong Zhou, Youqing Shen
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09729-xThe fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protein- and peptide-based (...)

Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing

mercredi 19 novembre 2025 par Zidan Yang, Miho Inagaki, Charles R. Gerfen, Lorenzo Fontolan, Hidehiko K. Inagaki
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09778-2How the mouse frontal cortex and striatum interact to implement integrator dynamics controlling movement timing is explored.

Hepatic zonation determines tumorigenic potential of mutant ?-catenin

mercredi 19 novembre 2025 par Alexander Raven, Kathryn Gilroy, Hu Jin, Joseph A. Waldron, Holly Leslie, June Munro, Holly Hall, Rachel A. Ridgway, Catriona A. Ford, Doga C. Gulhan, Nikola Vlahov, Megan L. Mills, Andrew Hartley, Eve Anderson, Sheila Bryson, Nathalie Sphyris, Miryam Müller, Stephanie May, Barbara Cadden, Colin Nixon, Scott H. Waddell, Rachel Guest, Luke Boulter, Nick Barker, Hans Clevers, Hao Zhu, Johanna Ivaska, Douglas Strathdee, Crispin J. Miller, Nigel B. Jamieson, Martin Bushell, Peter J. Park, Thomas G. Bird, Owen J. Sansom
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09733-1Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.

Repulsions instruct synaptic partner matching in an olfactory circuit

mercredi 19 novembre 2025 par Zhuoran Li, Cheng Lyu, Chuanyun Xu, Ying Hu, David J. Luginbuhl, Asaf B. Caspi-Lebovic, Jessica M. Priest, Engin Özkan, Liqun Luo
Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09768-4Transcriptomic screening identifies pairs of cell-surface proteins that mediate repulsive interactions between axons and dendrites of non-cognate partner neurons, thereby contributing to correct synaptic partner (...)

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