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Continuous-variable multipartite entanglement in an integrated microcomb

mercredi 19 février 2025 par Xinyu Jia, Chonghao Zhai, Xuezhi Zhu, Chang You, Yunyun Cao, Xuguang Zhang, Yun Zheng, Zhaorong Fu, Jun Mao, Tianxiang Dai, Lin Chang, Xiaolong Su, Qihuang Gong, Jianwei Wang

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08602-1Deterministic generation of a continuous-variable eight-mode entanglement on an integrated optical chip is reported.

Nature

Plasmodium blood stage development requires the chromatin remodeller Snf2L

mercredi 19 février 2025 par Maria Theresia Watzlowik, Elisabeth Silberhorn, Sujaan Das, Ritwik Singhal, Kannan Venugopal, Simon Holzinger, Barbara Stokes, Ella Schadt, Lauriane Sollelis, Victoria A. Bonnell, Matthew Gow, Andreas Klingl, Matthias Marti, Manuel Llinás, Markus Meissner, Gernot Längst

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08595-xPlasmodium falciparum Snf2L is an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vivo.

Nature

A dual-pathway architecture for stress to disrupt agency and promote habit

mercredi 19 février 2025 par Jacqueline R. Giovanniello, Natalie Paredes, Anna Wiener, Kathia Ramírez-Armenta, Chukwuebuka Oragwam, Hanniel O. Uwadia, Abigail L. Yu, Kayla Lim, Jenna S. Pimenta, Gabriela E. Vilchez, Gift Nnamdi, Alicia Wang, Megha Sehgal, Fernando MCV Reis, Ana C. Sias, Alcino J. Silva, Avishek Adhikari, Melissa Malvaez, Kate M. Wassum

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08580-wAdaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain pathway needed for agency (...)

Nature

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1

mercredi 19 février 2025 par Tatsuya Yamada, Arisa Ikeda, Daisuke Murata, Hu Wang, Cissy Zhang, Pratik Khare, Yoshihiro Adachi, Fumiya Ito, Pedro M. Quirós, Seth Blackshaw, Carlos López-Otín, Thomas Langer, David C. Chan, Anne Le, Valina L. Dawson, Ted M. Dawson, Miho Iijima, Hiromi Sesaki

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08590-2We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, mitochondrial (...)

Nature

Cooperative nutrient scavenging is an evolutionary advantage in cancer

mercredi 19 février 2025 par Gizem Guzelsoy, Setiembre D. Elorza, Manon Ros, Logan T. Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S. Brunner, Ray Pillai, William E. Walkowicz, Lydia W. S. Finley, Maxime Deforet, Thales Papagiannakopoulos, Carlos Carmona-Fontaine

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08588-wNutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino (...)

Nature

Spontaneous ordering of identical materials into a triboelectric series

mercredi 19 février 2025 par Juan Carlos Sobarzo, Felix Pertl, Daniel M. Balazs, Tommaso Costanzo, Markus Sauer, Annette Foelske, Markus Ostermann, Christian M. Pichler, Yongkang Wang, Yuki Nagata, Mischa Bonn, Scott Waitukaitis

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08530-6Nominally identical materials are found to spontaneously order into triboelectric series over repeated processes, which is found to be driven by the act of contact itself using experiments as well as numerical (...)

Nature

Tumour-wide RNA splicing aberrations generate actionable public neoantigens

mercredi 19 février 2025 par Darwin W. Kwok, Nicholas O. Stevers, Iñaki Etxeberria, Takahide Nejo, Maggie Colton Cove, Lee H. Chen, Jangham Jung, Kaori Okada, Senthilnath Lakshmanachetty, Marco Gallus, Abhilash Barpanda, Chibo Hong, Gary K. L. Chan, Jerry Liu, Samuel H. Wu, Emilio Ramos, Akane Yamamichi, Payal B. Watchmaker, Hirokazu Ogino, Atsuro Saijo, Aidan Du, Nadia R. Grishanina, James Woo, Aaron Diaz, Shawn L. Hervey-Jumper, Susan M. Chang, Joanna J. Phillips, Arun P. Wiita, Christopher A. Klebanoff, Joseph F. Costello, Hideho Okada

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08552-0A study identifies public neoantigens generated by tumor-wide aberrant mRNA splicing activity across distinct cancer types.

Nature

Human-correlated genetic models identify precision therapy for liver cancer

mercredi 19 février 2025 par Miryam Müller, Stephanie May, Holly Hall, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Anastasia Georgakopoulou, Thomas Jamieson, Narisa Phinichkusolchit, Sandeep Dhayade, Toshiyasu Suzuki, Júlia Huguet-Pradell, Ian R. Powley, Leah Officer-Jones, Rachel L. Pennie, Roger Esteban-Fabró, Albert Gris-Oliver, Roser Pinyol, George L. Skalka, Jack Leslie, Matthew Hoare, Joep Sprangers, Gaurav Malviya, Agata Mackintosh, Emma Johnson, Misti McCain, John Halpin, Christos Kiourtis, Colin Nixon, Graeme Clark, William Clark, Robin Shaw, Ann Hedley, Thomas M. Drake, Ee Hong Tan, Matt Neilson, Daniel J. Murphy, David Y. Lewis, Helen L. Reeves, John Le Quesne, Derek A. Mann, Leo M. Carlin, Karen Blyth, Josep M. Llovet, Markus H. Heim, Owen J. Sansom, Crispin J. Miller, Thomas G. Bird

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08585-zAs proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective (...)

Nature

An opponent striatal circuit for distributional reinforcement learning

mercredi 19 février 2025 par Adam S. Lowet, Qiao Zheng, Melissa Meng, Sara Matias, Jan Drugowitsch, Naoshige Uchida

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08488-5D1- and D2-expressing striatal neurons encode separate parts of a learned reward distribution, paralleling modern approaches in machine learning.

Nature

Scale dichotomization reduces customer racial discrimination and income inequality

mercredi 19 février 2025 par Tristan L. Botelho, Sora Jun, Demetrius Humes, Katherine A. DeCelles

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08599-7Changing from a five-point scale to a two-point scale for rating workers reduces racial discrimination by making customers focus on whether the work was good or bad instead of their own personal (...)

Nature