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Linear RAG scanning mediates editing of Ig? variable region repertoires

mercredi 15 avril 2026 par Xiang Li, Hongli Hu, Yiwen Zhang, Tammie Zhu, Ying Guan, Kai Xu, Xin Lin, Camille Hebert, Himanshu Batra, Jenny Zhou, Zhaoqing Ba, Duane R. Wesemann, Adam Yongxin Ye, Frederick W. Alt

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based (...)

Nature

Monolithic 3D integration of tantalum pentoxide nonlinear photonics

mercredi 15 avril 2026 par Grant M. Brodnik, Grisha Spektor, Lindell M. Williams, Jizhao Zang, Alexa R. Carollo, Atasi Dan, Jennifer A. Black, David R. Carlson, Scott B. Papp

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10379-wMonolithic three-dimensional (3D) integration of tantalum pentoxide on a lithium niobate substrate enables scalable, multifunctional photonic systems and the incorporation of nonlinear optics directly into existing and (...)

Nature

Carbonyl swapping converts cyclic ketones to saturated heterocycles

mercredi 15 avril 2026 par Zisheng Xue, Zhengzhao Lou, Xiang Lou, Peimiao He, Jianbo Wang, Yan Xu

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5Carbonyl swapping converts cyclic ketones to saturated heterocycles

Nature

Giant cancer study reveals effectiveness of ‘off label’ treatments

mercredi 15 avril 2026 par Benjamin Thompson

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human (...)

Nature

Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements

mercredi 15 avril 2026 par William C. Hahn, Christopher M. Counter, Ante S. Lundberg, Roderick L. Beijersbergen, Mary W. Brooks, Robert A. Weinberg

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements

Nature

Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells

mercredi 15 avril 2026 par Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K. Sundaresan, Joseph A. Licausi, Rushil Desai, Ryan M. O’Keefe, Richard Y. Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L. Onozato, Anthony J. Iafrate, Ravi Kapur, Dennis Sgroi, David T. Ting, Mehmet Toner, Sridhar Ramaswamy, Wilhelm Haas, Shyamala Maheswaran, Daniel A. Haber

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells

Nature

Retraction Note: The hidden fitness of the male zebra finch courtship song

mercredi 15 avril 2026 par Danyal Alam, Fayha Zia, Todd F. Roberts

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10483-xRetraction Note: The hidden fitness of the male zebra finch courtship song

Nature

Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes

mercredi 15 avril 2026 par Zeynep Ilg?n K?l?ç, Joyce van Loenhout, Marten Chaillet, Robert M. van Es, Paula Sobrevals Alcaraz, Harmjan R. Vos, Willem E. M. Noteborn, Miguel Ricardo Leung

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10513-8Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes

Nature

Author Correction: Multi-omic profiling reveals age-related immune dynamics in healthy adults

vendredi 10 avril 2026 par Qiuyu Gong, Mehul Sharma, Marla C. Glass, Emma L. Kuan, Aishwarya Chander, Mansi Singh, Lucas T. Graybuck, Zachary J. Thomson, Christian M. LaFrance, Samir Rachid Zaim, Tao Peng, Lauren Y. Okada, Palak C. Genge, Katherine E. Henderson, Elisabeth M. Dornisch, Erik D. Layton, Peter J. Wittig, Alexander T. Heubeck, Nelson M. Mukuka, Julian Reading, Garrett Strawn, Teminijesu Titus-Adewunmi, Kathleen Abadie, Charles R. Roll, Veronica Hernandez, Vaishnavi Parthasarathy, Tyanna J. Stuckey, Blessing Musgrove, Elliott Swanson, Cara Lord, Morgan D. A. Weiss, Cole G. Phalen, Regina R. Mettey, Kevin J. Lee, John B. Johanneson, Erin K. Kawelo, Jessica Garber, Upaasana Krishnan, Megan Smithmyer, E. John Wherry, Laura A. Vella, Sarah E. Henrickson, Mackenzie S. Kopp, Adam K. Savage, Lynne A. Becker, Paul Meijer, Ernest M. Coffey, Jorg J. Goronzy, Mikael Sigvardsson, Cate Speake, Thomas F. Bumol, Ananda W. Goldrath, Troy R. Torgerson, Xiao-jun Li, Peter J. Skene, Jane H. Buckner, Claire E. Gustafson

Nature, Published online: 10 April 2026; doi:10.1038/s41586-026-10484-wAuthor Correction: Multi-omic profiling reveals age-related immune dynamics in healthy adults

Nature