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Take a risk or play it safe? Neuronal tug-of-war helps the brain decide

jeudi 17 septembre 2026 par Miryam Naddaf

Nature, Published online: 17 September 2026; doi:10.1038/d41586-026-02911-9Using a video game involving bombs and treasure chests, researchers show how neural activity flickers between two regions of the frontal cortex when the brain weighs up a tricky (...)

Nature

How a team of AIs discovered a promising lung-cancer drug

jeudi 17 septembre 2026 par Ewen Callaway

Nature, Published online: 17 September 2026; doi:10.1038/d41586-026-02954-yResearchers developed a ‘virtual biotech’ made up of as many as 37,000 agents reporting to an 'chief scientist'.

Nature

Who gets credit in the AI era? OpenAI maths bombshell sparks debate

jeudi 17 septembre 2026 par Davide Castelvecchi

Nature, Published online: 17 September 2026; doi:10.1038/d41586-026-02910-wControversy around OpenAI’s claim to have solved the Navier–Stokes problem highlights how researchers could be inadvertently sharing — and absorbing— ideas through (...)

Nature

Inflection points and transitions in Alzheimer’s disease

mercredi 16 septembre 2026 par Bart De Strooper, Eric Karran

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11110-5Inflection points and transitions in Alzheimer’s disease

Nature

Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors

mercredi 16 septembre 2026 par Yujun Peng, Hainan Tian, Zhenhua Ming, Tongjun Sun, Jiuyang Yu, Mingsong Wu, Danyi Huang, Yihan Zhang, Zhenhui Zhong, Xin Li, Yuelin Zhang

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11123-0Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors

Nature

Why most stars don’t have outbursts like the Sun’s

mercredi 16 septembre 2026

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02833-6A strong magnetic field can disrupt a star’s ability to produce the fountains of matter called coronal mass ejections.

Nature

Transplanted human brain-tissue takes root in mice without a cortex

mercredi 16 septembre 2026 par Benjamin Thompson, Nick Petri? Howe

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02927-1Extensive cellular integration might provide platform for in vivo testing of new therapies — plus, the AI tool that turns papers into ‘virtual corresponding (...)

Nature

Development of a random background to understand ligand optimization

mercredi 16 septembre 2026 par Xinyu Xu, Olivier Mailhot, Galen J. Correy, Xi-Ping Huang, Joao M. Braz, Da Shi, Karthik Srinivasan, Kara Zielinski, Yuliia Holota, Yuliia Kuziv, Christos Iliopoulos-Tsoutsouvas, Nathan D. Levinzon, Yagmur U. Doruk, Moira M. Rachman, Morgan E. Diolaiti, Maisie G. V. Stevens, Fangyu Liu, Katie L. Holland, Harald Hübner, Jing Wang, Yujin Wu, Alan Ashworth, Alexandros Makriyannis, Yuqi Zhang, Yurii S. Moroz, Peter Gmeiner, Robert Abel, Aashish Manglik, Allan I. Basbaum, Bryan L. Roth, James S. Fraser, Brian K. Shoichet

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Nature

Developmental xenocortication using human-derived organoids in mice

mercredi 16 septembre 2026 par Konstantin Kaganovsky, Kevin W. Kelley, Tilo Gschwind, Paul M. Harary, John Kochalka, Alexander D. White, Garikoitz Lerma-Usabiaga, Xiaoyu Chen, Omer Revah, Felicity Gore, Ayano Aoyama, Jennifer L. Shadrach, Se-Jin Yoon, Alfredo Valencia, Satoe Ogawa, Noah Reis, Hannes Vogel, Brian Wandell, Julia A. Kaltschmidt, Ivan Soltesz, Karl Deisseroth, Sergiu P. Pa?ca

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Nature

Mitochondrial fission factor senses and governs ferroptosis

mercredi 16 septembre 2026 par Songjun Dai, Xiaoyan Dai, Tingting Zhang, Yuanyuan Qi, Xinquan Yang, Pengfei Diao, Chaodong Ge, Wenxiang Huang, Jisheng Ran, Xueliang Yang, Peng Zhang, Keke Zheng, Ruijun Wang, Hong Qian, Kunxiao Zhang, Junbing Wu, Caiyun Fu, Qian Ba, Junxia Min, Fudi Wang, Qiang Zhang

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11020-6The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables high-content screening of ferroptosis-sensitizing compounds and the (...)

Nature