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A spatial atlas of the healthy human liver from live donors

mercredi 15 avril 2026 par Oran Yakubovsky, Keren Bahar Halpern, Sapir Shir, Roy Novoselsky, Amichay Afriat, Adi Egozi, Tal Barkai, Yotam Harnik, Rouven Hoefflin, Yael Korem Kohanim, Ofra Golani, Inna Goliand, Yoseph Addadi, Merav Kedmi, Hadas Keren-Shaul, Liat Fellus-Alyagor, Lena Prichislov, Dana Hirsch, Chen Mayer, Ron Pery, Niv Pencovich, Timucin Taner, Ido Nachmany, Shalev Itzkovitz

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10377-yA human spatial atlas of gene expression in liver based on live donors shows marked porto–central zonation of hepatocytes and non-parenchymal cells, and transcriptomic changes in early (...)

Nature

A mechanism for adaptive genome regulation in cancer

mercredi 15 avril 2026 par Gustavo S. França, Itai Yanai

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is (...)

Nature

Molecular basis for methylation-sensitive editing by Cas9

mercredi 15 avril 2026 par Mitchell O. Roth, Yuerong Shu, Yu Zhao, Despoina Trasanidou, Renee D. Hoffman, Christian Südfeld, Eugenios Bouzetos, Nikolaos Trasanidis, Michael Zawrotny, Mary K. Gelasco, Megan L. Medina, Anuska Das, Jay Rai, Hemant N. Goswami, Bing Wang, John van der Oost, Hong Li

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10384-zThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer (...)

Nature

Template-driven scaffolding of SCF^FBXO42 regulates PP2A degradation

mercredi 15 avril 2026 par Sebastien Coassolo, Nairie Michaelian, Timurs Maculins, Caleigh M. Azumaya, Tommy K. Cheung, Jianping Yin, Inna Zilberleyb, Kanika Bajaj Pahuja, Thomas Garner, Ted Lau, Davis Mau, Matthew Grimmer, Jean-Philippe Fortin, Mike Costa, Yoana N. Dimitrova, Christopher M. Rose, Peter L. Hsu, Robert L. Yauch

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10368-zThe E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness

Nature

mRNA vaccines engage unconventional pathways in CD8⁺ T cell priming

mercredi 15 avril 2026 par Suin Jo, Lijin Li, Chandrani Thakur, Kevin A. Telfer, Hussein Sultan, Ray A. Ohara, Michelle He, Giri Nam, Jing Chen, Feiya Ou, Monia Draghi, Nicholas M. Valiante, Robert D. Schreiber, Gwendalyn J. Randolph, Naresha Saligrama, Theresa L. Murphy, William E. Gillanders, Kenneth M. Murphy

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells (...)

Nature

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers

mercredi 15 avril 2026 par Julian R. Buissant des Amorie, Joris H. Hageman, Sascha R. Brunner, Suzanne E. M. van der Horst, Maria C. Puschhof, Arne van Hoeck, Inge van Lierop, Sjors Middelkamp, Lisa van der Schee, Sven van Kempen, Folkert Morsink, Robin Geene, Sander Mertens, David S. Cavigelli, Ingrid Verlaan-Klink, Lianne J. Kraaier, Jorieke Salij, Renate Bezemer, Onno Kranenburg, Miangela M. Laclé, Leon M. G. Moons, Hugo J. G. Snippert

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in (...)

Nature

Tumour promotion through the lens of evolution

mercredi 15 avril 2026 par Nuria Lopez-Bigas, Eve Kandyba, Abel Gonzalez-Perez, Paul Brennan, Allan Balmain

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-xThis Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous (...)

Nature

Brainwide blood volume reflects opposing neural populations

mercredi 15 avril 2026 par Agnès Landemard, Michael Krumin, Kenneth D. Harris, Matteo Carandini

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10350-9Combined functional ultrasound imaging and Neuropixels recording of mouse brains identify two neuronal populations with opposing arousal-related activity and distinct haemodynamic response functions, that occur throughout (...)

Nature

Ancient DNA reveals pervasive directional selection across West Eurasia

mercredi 15 avril 2026 par Ali Akbari, Annabel Perry, Alison R. Barton, Mohammadreza Kariminejad, Steven Gazal, Zheng Li, Yating Zeng, Alissa Mittnik, Nick Patterson, Matthew Mah, Xiang Zhou, Alkes L. Price, Eric S. Lander, Ron Pinhasi, Nadin Rohland, Swapan Mallick, David Reich

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10358-1Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being rare over this period as (...)

Nature

Identifying the topographic signature of early Martian oceans

mercredi 15 avril 2026 par Abdallah S. Zaki, Michael P. Lamb

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10381-2Shelves rather than shorelines may be better topographic indicators of oceans on Earth and Mars.

Nature