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Targeted mRNA therapy tackles deadly pregnancy condition in mice

mercredi 11 décembre 2024 par Nick Petri? Howe, Emily Bates

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04097-4Treatment delivered directly to the placenta restores normal blood pressure in mice, a way to make custom cellular switches, and a milestone for quantum (...)

Nature

Distant sparkles hint at how the Milky Way formed

mercredi 11 décembre 2024 par Brian Welch

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03849-6The JWST has captured images of the Firefly Sparkle — a galaxy that resembles an early Milky Way — in the process of being assembled from star clusters. The discovery could help to reveal how the Milky Way formed in the (...)

Nature

Bone repair supported by flexible films made using an innovative method

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04033-6A scalable strategy for fabricating high-performance films of 2D inorganic materials called MXenes has been developed. The resulting MXene films show excellent performance in guiding bone regeneration and in other (...)

Nature

X-ray method takes a 3D fingerprint of materials

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04036-3A material’s properties are determined by its composition and microstructure — the distribution and orientation of its building blocks. A non-destructive imaging technique has been developed that measures local variations (...)

Nature

A gut fungus protects mice against parasitic worms but increases allergies

mercredi 11 décembre 2024 par Suzanne Noble

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03651-4It has been hard to find fungi that normally reside in the mouse gut. The identification of one such fungus deepens our understanding of how resident fungi drive immune responses in their natural (...)

Nature

Constraint reveals the mitochondrial genome sites most important for health and disease

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04039-0Mitochondrial DNA (mtDNA) is the part of the genome found in mitochondria, the ‘powerhouses’ of the cell. An analysis of mitochondrial genomes from nearly 60,000 people shows where selection has removed deleterious genetic (...)

Nature

‘Getting paid to review is justice’: journal pays peer reviewers in cryptocurrency

mercredi 11 décembre 2024 par Holly Else

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04027-4ResearchHub Journal launches latest attempt to compensate referees for their labour.

Nature

Personalized ranges for blood-test results enable precision diagnostics

mercredi 11 décembre 2024 par Steven J. R. Meex, Kristin Moberg Aakre

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03854-9In medicine, a person’s blood-test results are compared with the average range in a population. But results are highly individual and tightly regulated around a person’s own stable values. Changes to these values can (...)

Nature

Reversing resistance to cancer immune therapy with antibodies that target GDF-15 protein

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04081-yThe protein GDF-15 is a potent immunosuppressor that is overexpressed in many solid tumours and impedes the effects of cancer immunotherapy. In a first-in-human clinical trial, the GDF-15-targeting antibody visugromab (...)

Nature

Will artificial intelligence help or hinder progress on the SDGs?

mercredi 11 décembre 2024 par Abdullahi Tsanni

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03959-1Synthetic data are one of many tools that can drive progress towards the Sustainable Development Goals, but environmental and ethical concerns remain.

Nature