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Bespoke vaccines can elicit long-lived immune activity against pancreatic cancer

mercredi 19 février 2025

Nature, Published online: 19 February 2025; doi:10.1038/d41586-025-00470-zCancer vaccines must induce immune cells, called CD8+ T cells, that can recognize cancer cells over the long term. In pancreatic cancer, a common and deadly cancer, RNA vaccines that encode neoantigens — mutant proteins (...)

Nature

Artificial intelligence for modelling infectious disease epidemics

mercredi 19 février 2025 par Moritz U. G. Kraemer, Joseph L.-H. Tsui, Serina Y. Chang, Spyros Lytras, Mark P. Khurana, Samantha Vanderslott, Sumali Bajaj, Neil Scheidwasser, Jacob Liam Curran-Sebastian, Elizaveta Semenova, Mengyan Zhang, H. Juliette T. Unwin, Oliver J. Watson, Cathal Mills, Abhishek Dasgupta, Luca Ferretti, Samuel V. Scarpino, Etien Koua, Oliver Morgan, Houriiyah Tegally, Ulrich Paquet, Loukas Moutsianas, Christophe Fraser, Neil M. Ferguson, Eric J. Topol, David A. Duchêne, Tanja Stadler, Patricia Kingori, Michael J. Parker, Francesca Dominici, Nigel Shadbolt, Marc A. Suchard, Oliver Ratmann, Seth Flaxman, Edward C. Holmes, Manuel Gomez-Rodriguez, Bernhard Schölkopf, Christl A. Donnelly, Oliver G. Pybus, Simon Cauchemez, Samir Bhatt

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08564-wThis Perspective considers the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data (...)

Nature

Continuous-variable multipartite entanglement in an integrated microcomb

mercredi 19 février 2025 par Xinyu Jia, Chonghao Zhai, Xuezhi Zhu, Chang You, Yunyun Cao, Xuguang Zhang, Yun Zheng, Zhaorong Fu, Jun Mao, Tianxiang Dai, Lin Chang, Xiaolong Su, Qihuang Gong, Jianwei Wang

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08602-1Deterministic generation of a continuous-variable eight-mode entanglement on an integrated optical chip is reported.

Nature

Plasmodium blood stage development requires the chromatin remodeller Snf2L

mercredi 19 février 2025 par Maria Theresia Watzlowik, Elisabeth Silberhorn, Sujaan Das, Ritwik Singhal, Kannan Venugopal, Simon Holzinger, Barbara Stokes, Ella Schadt, Lauriane Sollelis, Victoria A. Bonnell, Matthew Gow, Andreas Klingl, Matthias Marti, Manuel Llinás, Markus Meissner, Gernot Längst

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08595-xPlasmodium falciparum Snf2L is an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vivo.

Nature

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1

mercredi 19 février 2025 par Tatsuya Yamada, Arisa Ikeda, Daisuke Murata, Hu Wang, Cissy Zhang, Pratik Khare, Yoshihiro Adachi, Fumiya Ito, Pedro M. Quirós, Seth Blackshaw, Carlos López-Otín, Thomas Langer, David C. Chan, Anne Le, Valina L. Dawson, Ted M. Dawson, Miho Iijima, Hiromi Sesaki

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08590-2We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, mitochondrial (...)

Nature

Community estimate of global glacier mass changes from 2000 to 2023

mercredi 19 février 2025 par Michael Zemp, Livia Jakob, Inés Dussaillant, Samuel U. Nussbaumer, Noel Gourmelen, Sophie Dubber, Geruo A, Sahra Abdullahi, Liss Marie Andreassen, Etienne Berthier, Atanu Bhattacharya, Alejandro Blazquez, Laura F. Boehm Vock, Tobias Bolch, Jason Box, Matthias H. Braun, Fanny Brun, Eric Cicero, William Colgan, Nicolas Eckert, Daniel Farinotti, Caitlyn Florentine, Dana Floricioiu, Alex Gardner, Christopher Harig, Javed Hassan, Romain Hugonnet, Matthias Huss, Tómas Jóhannesson, Chia-Chun Angela Liang, Chang-Qing Ke, Shfaqat Abbas Khan, Owen King, Marin Kneib, Lukas Krieger, Fabien Maussion, Enrico Mattea, Robert McNabb, Brian Menounos, Evan Miles, Geir Moholdt, Johan Nilsson, Finnur Pálsson, Julia Pfeffer, Livia Piermattei, Stephen Plummer, Andreas Richter, Ingo Sasgen, Lilian Schuster, Thorsten Seehaus, Xiaoyi Shen, Christian Sommer, Tyler Sutterley, Désirée Treichler, Isabella Velicogna, Bert Wouters, Harry Zekollari, Whyjay Zheng

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08545-zAn intercomparison exercise reassesses mass loss from glaciers worldwide based on the main in situ and satellite methods from 2000 to 2023; the results are consistent with previous assessments and provide a refined and (...)

Nature

A dual-pathway architecture for stress to disrupt agency and promote habit

mercredi 19 février 2025 par Jacqueline R. Giovanniello, Natalie Paredes, Anna Wiener, Kathia Ramírez-Armenta, Chukwuebuka Oragwam, Hanniel O. Uwadia, Abigail L. Yu, Kayla Lim, Jenna S. Pimenta, Gabriela E. Vilchez, Gift Nnamdi, Alicia Wang, Megha Sehgal, Fernando MCV Reis, Ana C. Sias, Alcino J. Silva, Avishek Adhikari, Melissa Malvaez, Kate M. Wassum

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08580-wAdaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain pathway needed for agency (...)

Nature

Tumour-wide RNA splicing aberrations generate actionable public neoantigens

mercredi 19 février 2025 par Darwin W. Kwok, Nicholas O. Stevers, Iñaki Etxeberria, Takahide Nejo, Maggie Colton Cove, Lee H. Chen, Jangham Jung, Kaori Okada, Senthilnath Lakshmanachetty, Marco Gallus, Abhilash Barpanda, Chibo Hong, Gary K. L. Chan, Jerry Liu, Samuel H. Wu, Emilio Ramos, Akane Yamamichi, Payal B. Watchmaker, Hirokazu Ogino, Atsuro Saijo, Aidan Du, Nadia R. Grishanina, James Woo, Aaron Diaz, Shawn L. Hervey-Jumper, Susan M. Chang, Joanna J. Phillips, Arun P. Wiita, Christopher A. Klebanoff, Joseph F. Costello, Hideho Okada

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08552-0A study identifies public neoantigens generated by tumor-wide aberrant mRNA splicing activity across distinct cancer types.

Nature

Cooperative nutrient scavenging is an evolutionary advantage in cancer

mercredi 19 février 2025 par Gizem Guzelsoy, Setiembre D. Elorza, Manon Ros, Logan T. Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S. Brunner, Ray Pillai, William E. Walkowicz, Lydia W. S. Finley, Maxime Deforet, Thales Papagiannakopoulos, Carlos Carmona-Fontaine

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08588-wNutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino (...)

Nature

Spontaneous ordering of identical materials into a triboelectric series

mercredi 19 février 2025 par Juan Carlos Sobarzo, Felix Pertl, Daniel M. Balazs, Tommaso Costanzo, Markus Sauer, Annette Foelske, Markus Ostermann, Christian M. Pichler, Yongkang Wang, Yuki Nagata, Mischa Bonn, Scott Waitukaitis

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08530-6Nominally identical materials are found to spontaneously order into triboelectric series over repeated processes, which is found to be driven by the act of contact itself using experiments as well as numerical (...)

Nature