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EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk

mercredi 15 avril 2026 par Yanhong Chen, Jingtong Liang, Wanlin Zhang, Xinyu Zhang, Xinyi Zhang, Ching-Yuan Wang, Fei Yao, Shanshan Zhang, Xiang Zhou, Weimin Ye, Ruimei Feng, Yonglin Cai, Zhe Zhang, Mingfang Ji, Qian Cui, Xihong Lin, Jiesen Li, Jialei Xu, Qiuting Zhang, Qinyao Huang, Yingying Cheng, Yanran Luo, Xiaoping Ye, Qisheng Feng, Minzhong Tang, Mu-Sheng Zeng, Yi-Xin Zeng, Zhonghua Liu, Weiwei Zhai, Jianjun Liu, Miao Xu

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Nature

Mapping convergent regulators of melanoma drug resistance by PerturbFate

mercredi 15 avril 2026 par Zihan Xu, Ziyu Lu, Aileen Ugurbil, Abdulraouf Abdulraouf, Andrew Liao, Jianxiang Zhang, Wei Zhou, Junyue Cao

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic (...)

Nature

Imaging interface-controlled bulk oxygen spillover

mercredi 15 avril 2026 par Weijue Wang, Hongbin Xu, Shuhui Liu, Xiaofeng Yang, Wei Liu, Yang-Gang Wang, Yanqiang Huang, Tao Zhang

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10324-xIn situ microscopic single-particle imaging demonstrates the significance of rationally engineered metal–support interfaces for activating the oxygen in bulk catalyst, helping elucidate reaction pathways in catalytic (...)

Nature

300-unit-per-second roll-to-roll manufacturing of visible metalenses

mercredi 15 avril 2026 par Trung Hoang, Yujin Park, Joohoon Kim, Han Truong, Sajjan Parajuli, Beniel Jones Rajasekaran, Kyungtae Kim, Dohyun Kang, Gyoseon Jeon, Kyung-il Lee, Dong Hyun Yoon, Inki Kim, Junsuk Rho, Gyoujin Cho

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10369-yThis work demonstrates industrial-scale roll-to-roll fabrication of high-efficiency visible metalenses using nanoimprinting and TiO2 coating, achieving low cost, high throughput and uniform performance, enabling (...)

Nature

Pixelated quantum-dot superlattice LEDs

mercredi 15 avril 2026 par Chengxi Zhang, Qingsen Zeng, Hui Li, Renjun Guo, Yue Yu, Linjie Dai, Lyudmila Turyanska, Zirui Liu, Jun Dai, Yingguo Yang, Yue Zhao, Jun Lu, Lin Wang, Lingmei Kong, Tze Chien Sum, Yuchen Wu, Tae-Woo Lee, Xuyong Yang

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10392-zScalable fabrication of ordered perovskite quantum dot superlattices enables high-efficiency, ultrahigh-resolution LEDs and active-matrix displays with greatly improved brightness, stability and device (...)

Nature

Language models transmit behavioural traits through hidden signals in data

mercredi 15 avril 2026 par Alex Cloud, Minh Le, James Chua, Jan Betley, Anna Sztyber-Betley, Sören Mindermann, Jacob Hilton, Samuel Marks, Owain Evans

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10319-8During model distillation, large language models can subtly transmit traits unrelated to the training data.

Nature

The neural mechanisms supporting the rise and fall of maternal aggression

mercredi 15 avril 2026 par Takashi Yamaguchi, Rongzhen Yan, Mashrur Khan, Sota Kuno, Kanishk Tewatia, Takuya Osakada, Srinivas Parthasarathy, Michael E. Pacold, Nirao M. Shah, Dayu Lin

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10354-5In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during (...)

Nature

Continuously tunable coherent pulse generation in a semiconductor laser

mercredi 15 avril 2026 par Urban Senica, Michael A. Schreiber, Marco Raffa, Paolo Micheletti, Mattias Beck, Christian Jirauschek, Jérôme Faist, Giacomo Scalari

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10387-wA monolithic mode-locked semiconductor laser with a continuously and widely tunable repetition rate is achieved by using a microwave driving signal that induces a spatiotemporal gain modulation along the entire laser (...)

Nature

Prospective evaluation of genomics-guided off-label treatment

mercredi 15 avril 2026 par K. Verkerk, A. C. Spiekman, S. F. Haj Mohammad, F. A. J. Verbeek, H. Timmer, M. A. van Maren, L. J. Zeverijn, B. S. Geurts, V. van der Noort, P. Roepman, A. M. L. Jansen, W. W. J. de Leng, H. Gelderblom, H. M. W. Verheul, E. E. Voest, H. H. Nienhuis, J. M. van Dodewaard-de Jong, M. Labots, D. J. A. de Groot, C. van Herpen, A. Hoeben, L. V. Beerepoot, E. D. Kerver, H. M. Westgeest, A. D. Bins, A. P. Hamberg, E. Boon, G. Vreugdenhil, G. J. de Klerk, T. van Voorthuizen, A. Vulink, F. van den Berkmortel, M. van Rooijen, D. Houtsma, A. L. T. Imholz, H. P. van den Berg, J. A. J. Douma, P. de Mol, S. Hovenga, M. P. Hendriks, J. W. B. de Groot, M. Los, S. Boudewijns, E. N. Klein Hesselink, E. Siemerink, S. C. S. Tromp, M. A. Davidis-van Schoonhoven, F. Jeurissen

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-xEvaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be (...)

Nature

Cell-type-targeted mitochondrial transplantation rescues cell degeneration

mercredi 15 avril 2026 par Temurkhan Ayupov, Verónica Moreno-Juan, Serena Curtoni, Alex Fratzl, Upnishad Sharma, Susana Posada-Céspedes, Ramona Ratiu, Rei Morikawa, Alexandra Graff Meyer, Margherita Pezzoli, Glenn Bantug, Morgan Chevalier, Yanyan Hou, Sarah A. Nadeau, Álvaro Herrero-Navarro, Vikram Ayinampudi, Elizabeth Kastanaki, Natasha Whitehead, Rebecca A. Siwicki, Mariana M. Ribeiro, Ji Hoon Han, Annalisa Bucci, Christoph Hess, Simone Picelli, Magdalena Renner, Daniel J. Müller, Cameron S. Cowan, Simon Hansen, Botond Roska

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target (...)

Nature