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Functional synapses between neurons and small cell lung cancer

mercredi 10 septembre 2025 par Vignesh Sakthivelu, Anna Schmitt, Franka Odenthal, Kristiano Ndoci, Marian Touet, Ali H. Shaib, Abdulla Chihab, Gulzar A. Wani, Pascal Nieper, Griffin G. Hartmann, Isabel Pintelon, Ilmars Kisis, Maike Boecker, Naja M. Eckert, Manoela Ianicelli Caiaffa, Olta Ibruli, Julia Weber, Roman Maresch, Christina M. Bebber, Ali Chitsaz, Anna Lütz, Mira Kim Alves Carpinteiro, Kaylee M. Morris, Camilla A. Franchino, Jonas Benz, Laura Pérez-Revuelta, Jorge A. Soriano-Campos, Maxim A. Huetzen, Jonas Goergens, Milica Jevtic, Hannah M. Jahn-Kelleter, Hans Zempel, Aleksandra Placzek, Alexandru A. Hennrich, Karl-Klaus Conzelmann, Hannah L. Tumbrink, Pascal Hunold, Joerg Isensee, Lisa Werr, Felix Gaedke, Astrid Schauss, Marielle Minère, Marie Müller, Henning Fenselau, Yin Liu, Alena Heimsoeth, Gülce S. Gülcüler Balta, Henning Walczak, Christian Frezza, Ron D. Jachimowicz, Julie George, Marcel Schmiel, Johannes Brägelmann, Tim Hucho, Silvia von Karstedt, Martin Peifer, Alessandro Annibaldi, Robert Hänsel-Hertsch, Thorsten Persigehl, Holger Grüll, Martin L. Sos, Guido Reifenberger, Matthias Fischer, Dirk Adriaensen, Reinhard Büttner, Julien Sage, Inge Brouns, Roland Rad, Roman K. Thomas, Max Anstötz, Silvio O. Rizzoli, Matteo Bergami, Elisa Motori, Hans Christian Reinhardt, Filippo Beleggia

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09434-9Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these (...)

Nature

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours

mercredi 10 septembre 2025 par Samarth Hegde, Bruno Giotti, Brian Y. Soong, Laszlo Halasz, Jessica Le Berichel, Maximilian M. Schaefer, Benoit Kloeckner, Raphaël Mattiuz, Matthew D. Park, Assaf Magen, Adam Marks, Meriem Belabed, Pauline Hamon, Theodore Chin, Leanna Troncoso, Juliana J. Lee, Kaili Fan, Dughan Ahimovic, Michael J. Bale, Kai Nie, Grace Chung, Darwin D’souza, Krista Angeliadis, Seunghee Kim-Schulze, Raja M. Flores, Andrew J. Kaufman, Florent Ginhoux, Jason D. Buenrostro, Steven Z. Josefowicz, Alexander M. Tsankov, Thomas U. Marron, Sai Ma, Brian D. Brown, Miriam Merad

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09493-yAn understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and developing more effective (...)

Nature

Redox-driven mineral and organic associations in Jezero Crater, Mars

mercredi 10 septembre 2025 par Joel A. Hurowitz, M. M. Tice, A. C. Allwood, M. L. Cable, K. P. Hand, A. E. Murphy, K. Uckert, J. F. Bell III, T. Bosak, A. P. Broz, E. Clavé, A. Cousin, S. Davidoff, E. Dehouck, K. A. Farley, S. Gupta, S.-E. Hamran, K. Hickman-Lewis, J. R. Johnson, A. J. Jones, M. W. M. Jones, P. S. Jørgensen, L. C. Kah, H. Kalucha, T. V. Kizovski, D. A. Klevang, Y. Liu, F. M. McCubbin, E. L. Moreland, G. Paar, D. A. Paige, A. C. Pascuzzo, M. S. Rice, M. E. Schmidt, K. L. Siebach, S. Siljeström, J. I. Simon, K. M. Stack, A. Steele, N. J. Tosca, A. H. Treiman, S. J. VanBommel, L. A. Wade, B. P. Weiss, R. C. Wiens, K. H. Williford, R. Barnes, P. A. Barr, A. Bechtold, P. Beck, K. Benzerara, S. Bernard, O. Beyssac, R. Bhartia, A. J. Brown, G. Caravaca, E. L. Cardarelli, E. A. Cloutis, A. G. Fairén, D. T. Flannery, T. Fornaro, T. Fouchet, B. Garczynski, F. Goméz, E. M. Hausrath, C. M. Heirwegh, C. D. K. Herd, J. E. Huggett, J. L. Jørgensen, S. W. Lee, A. Y. Li, J. N. Maki, L. Mandon, N. Mangold, J. A. Manrique, J. Martínez-Frías, J. I. Núñez, L. P. O’Neil, B. J. Orenstein, N. Phelan, C. Quantin-Nataf, P. Russell, M. D. Schulte, E. Scheller, S. Sharma, D. L. Shuster, A. Srivastava, B. V. Wogsland, Z. U. Wolf

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09413-0A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures (...)

Nature

Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

mercredi 10 septembre 2025 par Tsuyoshi Iizuka, Takazo Shibuya, Takehito Hayakawa, Tetsuya Yokoyama, Ikshu Gautam, Makiko K. Haba, Kengo T. M. Ito, Yuki Hibiya, Akira Yamaguchi, Yoshinari Abe, Jérôme Aléon, Conel M. O’D. Alexander, Sachiko Amari, Yuri Amelin, Ken-ichi Bajo, Martin Bizzarro, Audrey Bouvier, Richard W. Carlson, Marc Chaussidon, Byeon-Gak Choi, Nicolas Dauphas, Andrew M. Davis, Tommaso Di Rocco, Wataru Fujiya, Ryota Fukai, Hiroshi Hidaka, Hisashi Homma, Gary R. Huss, Trevor R. Ireland, Akira Ishikawa, Shoichi Itoh, Noriyuki Kawasaki, Noriko T. Kita, Koki Kitajima, Thorsten Kleine, Shintaro Komatani, Alexander N. Krot, Ming-Chang Liu, Yuki Masuda, Kazuko Motomura, Frédéric Moynier, Kazuhide Nagashima, Izumi Nakai, Ann Nguyen, Larry Nittler, Andreas Pack, Changkun Park, Laurette Piani, Liping Qin, Sara Russell, Naoya Sakamoto, Maria Schönbächler, Lauren Tafla, Haolan Tang, Kentaro Terada, Yasuko Terada, Tomohiro Usui, Sohei Wada, Meenakshi Wadhwa, Richard J. Walker, Katsuyuki Yamashita, Qing-Zhu Yin, Shigekazu Yoneda, Hiroharu Yui, Ai-Cheng Zhang, Tomoki Nakamura, Hiroshi Naraoka, Takaaki Noguchi, Ryuji Okazaki, Kanako Sakamoto, Hikaru Yabuta, Masanao Abe, Akiko Miyazaki, Aiko Nakato, Masahiro Nishimura, Tatsuaki Okada, Toru Yada, Kasumi Yogata, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Yuichi Tsuda, Sei-ichiro Watanabe, Makoto Yoshikawa, Shogo Tachibana, Hisayoshi Yurimoto

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09483-0Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously (...)

Nature

Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus

mercredi 10 septembre 2025 par Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang, Shuangyue Ma, Ying Jin, Jinjian Fu, Chenlu Liu, Jiahui Peng, Ruoran Wang, Lin Liu, Yi Zeng, Cheng Gong, Qing Zhou, Xiaomin Yu, Zhihong Liu

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09513-xPLD4 loss-of-function mutations in patients with systemic lupus erythematosus leads to excessive activation of TLR7 and TLR9.

Nature

Amplifying antigen-induced cellular responses with proximity labelling

mercredi 10 septembre 2025 par Shuojun Li, Yinghui Men, Zihan Wang, Yingcheng Wu, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao, Shuo Han

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09518-6Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour immune (...)

Nature

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis

mercredi 10 septembre 2025 par Solomiia Savchuk, Kaylee M. Gentry, Wengang Wang, Elana Carleton, Carlos A. O. Biagi-Junior, Karan Luthria, Belgin Yalç?n, Lijun Ni, Hannah C. Farnsworth, Rachel A. Davis, Richard Drexler, Johannes C. Melms, Yin Liu, Lehi Acosta-Alvarez, Griffin G. Hartmann, Elisa C. Pavarino, Jenna LaBelle, Pamelyn J. Woo, Angus M. Toland, Fangfei Qu, Yoon Seok Kim, Mariella G. Filbin, Mark A. Krasnow, Keith L. Ligon, Benjamin Izar, Julien Sage, Bernardo L. Sabatini, Michelle Monje, Humsa S. Venkatesh

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09492-zGlutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour (...)

Nature

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons

mercredi 10 septembre 2025 par Djuna von Maydell, Shannon E. Wright, Ping-Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, Guillaume Leclerc, Gloria Suella Menchaca, Gwyneth Welch, Agnese Graziosi, Noelle Leary, George Samaan, Manolis Kellis, Li-Huei Tsai

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09520-yLoss-of-function variants of ABCA7, associated with Alzheimer’s disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human (...)

Nature

Fluctuating DNA methylation tracks cancer evolution at clinical scale

mercredi 10 septembre 2025 par Calum Gabbutt, Martí Duran-Ferrer, Heather E. Grant, Diego Mallo, Ferran Nadeu, Jacob Househam, Neus Villamor, Madlen Müller, Simon Heath, Emanuele Raineri, Olga Krali, Jessica Nordlund, Thorsten Zenz, Ivo G. Gut, Elias Campo, Armando Lopez-Guillermo, Jude Fitzgibbon, Chris P. Barnes, Darryl Shibata, José I. Martin-Subero, Trevor A. Graham

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09374-4Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Nature

Stabilizing effect of amino acids on protein and colloidal dispersions

mercredi 10 septembre 2025 par Ting Mao, Xufeng Xu, Pamina M. Winkler, Cécilia Siri, Ekaterina Poliukhina, Paulo Jacob Silva, Nan Xu, Yu Hu, Karim Al Zahabi, Rémi La Polla, Zhi Luo, Quy Ong, Alfredo Alexander-Katz, Francesco Stellacci

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09506-wAmino acids possess a new and broad colloidal property: they stabilize patchy nanoscale colloids, such as proteins, by adsorbing onto their surfaces through weak (...)

Nature