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Evolution of taste processing shifts dietary preference

mercredi 26 novembre 2025 par Enrico Bertolini, Daniel Münch, Justine Pascual, Noemi Sgammeglia, Matteo Bruzzone, Carlos Ribeiro, Thomas O. Auer

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09766-6Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to peripheral receptor (...)

Nature

No meta-analytical effect of economic inequality on well-being or mental health

mercredi 26 novembre 2025 par Nicolas Sommet, Adrien A. Fillon, Ocyna Rudmann, Alfredo Rossi Saldanha Cunha, Annahita Ehsan

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09797-zA meta-analysis of 168 studies reveals that economic inequality is not significantly associated with subjective well-being or mental health.

Nature

Inhibitory PD-1 axis maintains high-avidity stem-like CD8⁺ T cells

mercredi 26 novembre 2025 par Jyh Liang Hor, Edward C. Schrom, Abigail Wong-Rolle, Luke Vistain, Wanjing Shang, Qiang Dong, Chen Zhao, Chengcheng Jin, Ronald N. Germain

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09440-xPD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade (...)

Nature

Inhibitors supercharge kinase turnover through native proteolytic circuits

mercredi 26 novembre 2025 par Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik, Xuefei Guo, Fabian Frommelt, Matthias Hinterndorfer, Hlib Razumkov, Polina Prokofeva, Martin P. Schwalm, Florian Born, Sandra Roehm, Hana Imrichova, Brianda L. Santini, Eleonora Barone, Caroline Schätz, Miquel Muñoz i Ordoño, Severin Lechner, Andrea Rukavina, Iciar Serrano, Miriam Abele, Anna Koren, Stefan Kubicek, Stefan Knapp, Nathanael S. Gray, Giulio Superti-Furga, Bernhard Kuster, Yigong Shi, Patrick Aloy, Georg E. Winter

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09763-9Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing (...)

Nature

Multi-qubit nanoscale sensing with entanglement as a resource

mercredi 26 novembre 2025 par Jared Rovny, Shimon Kolkowitz, Nathalie P. de Leon

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09760-yControlling pairs of nitrogen vacancy centres enables the measurement of magnetic correlations below the optical diffraction limit, and the use of entangled pairs shows a linear scaling of the measurement sensitivity with (...)

Nature

Ethylene modulates cell wall mechanics for root responses to compaction

mercredi 26 novembre 2025 par Jiao Zhang, Zengyu Liu, Edward J. Farrar, Minhao Li, Hui Lu, Zhuo Qu, Osvaldo Chara, Nobutaka Mitsuda, Shingo Sakamoto, Feiyang Xue, Qiji Shan, Ya Yu, Jingbin Li, Xiaobo Zhu, Mingyuan Zhu, Jin Shi, Lucas Peralta Ogorek, Augusto Borges, Malcolm J. Bennett, Wanqi Liang, Bipin K. Pandey, Dabing Zhang, Staffan Persson

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09765-7Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root radial (...)

Nature

iHALT unlocks liver functionality as a surrogate secondary lymphoid organ

mercredi 26 novembre 2025 par John Gridley, David Pak, Anuradha Kumari, Jacob Shupak, Brantley Holland, Yifeng Shi, Sheetal Trivedi, Yongtao Wang, Sudhir Pai Kasturi, Amit Kapoor, Raymond T. Chung, Arash Grakoui

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09803-4Liver-restricted viral infection in mice results in secondary lymphoid organ dormancy and the compensatory induction of specialized lymphoid tissue in the liver, the structural features and functional outputs of which are (...)

Nature

Building compositional tasks with shared neural subspaces

mercredi 26 novembre 2025 par Sina Tafazoli, Flora M. Bouchacourt, Adel Ardalan, Nikola T. Markov, Motoaki Uchimura, Marcelo G. Mattar, Nathaniel D. Daw, Timothy J. Buschman

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09805-2The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.

Nature

Slipknot-gauged mechanical transmission and robotic operation

mercredi 26 novembre 2025 par Yaoting Xue, Jiasheng Cao, Tao Feng, Kaihang Zhang, Siyang Li, Jiahao Hu, Haotian Guo, Jinming Zhang, Yaoxian Song, Zhuofan Wang, Lei Wang, Qishan Huang, Haofei Zhou, Fanghao Zhou, Jiliang Shen, Yaowei Fan, Zhe Wang, Xinge Li, Jie-Wei Wong, Zhiwei Chen, Dongrui Ruan, Zhikun Miao, Bin Zhang, Enjie Zhou, Letian Gan, Xuanqi Wang, Ertai Cao, Tong Chen, Weifeng Zou, Junhui Zhang, Haojian Lu, Qinghai Zhang, Song Liu, Huixu Dong, Shiying Xiong, Shuyou Peng, Tuck-Whye Wong, Yuanjie Chen, Tiefeng Li, Mingyu Chen, Xuxu Yang, Wei Yang, Xiujun Cai

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09673-wA mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven (...)

Nature

Vicarious body maps bridge vision and touch in the human brain

mercredi 26 novembre 2025 par Nicholas Hedger, Thomas Naselaris, Kendrick Kay, Tomas Knapen

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09796-0A mode of brain organization that connects visual and bodily reference frames may translate raw sensory impressions into more abstract formats that are useful for action, social cognition and semantic (...)

Nature