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Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase

mercredi 11 décembre 2024 par Cindy Meyer, Aitor Garzia, Michael W. Miller, David J. Huggins, Robert W. Myers, Hans-Heinrich Hoffmann, Alison W. Ashbrook, Syeda Y. Jannath, Nigel Liverton, Stacia Kargman, Matthew Zimmerman, Andrew M. Nelson, Vijeta Sharma, Enriko Dolgov, Julianna Cangialosi, Suyapa Penalva-Lopez, Nadine Alvarez, Ching-Wen Chang, Neelam Oswal, Irene Gonzalez, Risha Rasheed, Kira Goldgirsh, Jada A. Davis, Lavoisier Ramos-Espiritu, Miriam-Rose Menezes, Chloe Larson, Julius Nitsche, Oleg Ganichkin, Hanan Alwaseem, Henrik Molina, Stefan Steinbacher, J. Fraser Glickman, David S. Perlin, Charles M. Rice, Peter T. Meinke, Thomas Tuschl

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08320-0The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is (...)

Nature

Strong-field quantum control in the extreme ultraviolet domain using pulse shaping

mercredi 11 décembre 2024 par Fabian Richter, Ulf Saalmann, Enrico Allaria, Matthias Wollenhaupt, Benedetto Ardini, Alexander Brynes, Carlo Callegari, Giulio Cerullo, Miltcho Danailov, Alexander Demidovich, Katrin Dulitz, Raimund Feifel, Michele Di Fraia, Sarang Dev Ganeshamandiram, Luca Giannessi, Nicolai Gölz, Sebastian Hartweg, Bernd von Issendorff, Tim Laarmann, Friedemann Landmesser, Yilin Li, Michele Manfredda, Cristian Manzoni, Moritz Michelbach, Arne Morlok, Marcel Mudrich, Aaron Ngai, Ivaylo Nikolov, Nitish Pal, Fabian Pannek, Giuseppe Penco, Oksana Plekan, Kevin C. Prince, Giuseppe Sansone, Alberto Simoncig, Frank Stienkemeier, Richard James Squibb, Peter Susnjar, Mauro Trovo, Daniel Uhl, Brendan Wouterlood, Marco Zangrando, Lukas Bruder

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08209-yUltrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser.

Nature

Self-organized patterning of crocodile head scales by compressive folding

mercredi 11 décembre 2024 par Gabriel N. Santos-Durán, Rory L. Cooper, Ebrahim Jahanbakhsh, Grigorii Timin, Michel C. Milinkovitch

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08268-1Crocodile head scales self-organize through purely mechanical compressive skin folding rather than a patterning process controlled by gene interactions.

Nature

Lithium extraction from low-quality brines

mercredi 11 décembre 2024 par Sixie Yang, Yigang Wang, Hui Pan, Ping He, Haoshen Zhou

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08117-1Precipitation, solvent extraction, sorption, membrane-based separation and electrochemical-based separation are described as promising methods for extracting lithium from low-quality brines, which have extensive reserves (...)

Nature

Native DGC structure rationalizes muscular dystrophy-causing mutations

mercredi 11 décembre 2024 par Shiheng Liu, Tiantian Su, Xian Xia, Z. Hong Zhou

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08324-wThe detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.

Nature

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

mercredi 11 décembre 2024 par Kelsey L. Swingle, Alex G. Hamilton, Hannah C. Safford, Hannah C. Geisler, Ajay S. Thatte, Rohan Palanki, Amanda M. Murray, Emily L. Han, Alvin J. Mukalel, Xuexiang Han, Ryann A. Joseph, Aditi A. Ghalsasi, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08291-2A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders and women’s (...)

Nature

Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

mercredi 11 décembre 2024 par Ignacio Melero, Maria de Miguel Luken, Guillermo de Velasco, Elena Garralda, Juan Martín-Liberal, Markus Joerger, Guzman Alonso, Maria-Elisabeth Goebeler, Martin Schuler, David König, Reinhard Dummer, Maria Reig, Maria-Esperanza Rodriguez Ruiz, Emiliano Calvo, Jorge Esteban-Villarrubia, Arjun Oberoi, Paula Sabat, Juan José Soto-Castillo, Kira-Lee Koster, Omar Saavedra, Cyrus Sayehli, Tanja Gromke, Heinz Läubli, Egle Ramelyte, Marta Fortuny, Ana Landa-Magdalena, Irene Moreno, Javier Torres-Jiménez, Alberto Hernando-Calvo, Dagmar Hess, Fabricio Racca, Heike Richly, Andreas M. Schmitt, Corinne Eggenschwiler, Marco Sanduzzi-Zamparelli, Anna Vilalta-Lacarra, Jörg Trojan, Christine Koch, Peter R. Galle, Friedrich Foerster, Zlatko Trajanoski, Hubert Hackl, Falk Gogolla, Florestan J. Koll, Peter Wild, Felix Kyoung Hwan Chun, Henning Reis, Peter Lloyd, Matthias Machacek, Thomas F. Gajewski, Wolf H. Fridman, Alexander M. M. Eggermont, Ralf Bargou, Sandra Schöniger, Josef Rüschoff, Anastasiia Tereshchenko, Carina Zink, Antonio da Silva, Felix S. Lichtenegger, Julia Akdemir, Manfred Rüdiger, Phil L’Huillier, Aradhana Dutta, Markus Haake, Alexandra Auckenthaler, Ana Gjorgjioska, Bernhard Rössler, Frank Hermann, Mara Liebig, Daniela Reichhardt, Christine Schuberth-Wagner, Jörg Wischhusen, Petra Fettes, Marlene Auer, Kathrin Klar, Eugen Leo

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08305-zA study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistance to immune (...)

Nature

Discovery and engineering of the antibody response to a prominent skin commensal

mercredi 11 décembre 2024 par Djenet Bousbaine, Katherine D. Bauman, Y. Erin Chen, Pranav V. Lalgudi, Tam T. D. Nguyen, Joyce M. Swenson, Victor K. Yu, Eunice Tsang, Sean Conlan, David B. Li, Amina Jbara, Aishan Zhao, Arash Naziripour, Alessandra Veinbachs, Yu E. Lee, Jennie L. Phung, Alex Dimas, Sunit Jain, Xiandong Meng, Thi Phuong Thao Pham, Martin I. McLaughlin, Layla J. Barkal, Inta Gribonika, Koen K. A. Van Rompay, Heidi H. Kong, Julie A. Segre, Yasmine Belkaid, Christopher O. Barnes, Michael A. Fischbach

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08489-4Discovery and engineering of the antibody response to a prominent skin commensal

Nature

Structure and mechanism of the Zorya anti-phage defense system

mercredi 11 décembre 2024 par Haidai Hu, Philipp F. Popp, Thomas C. D. Hughes, Aritz Roa-Eguiara, Nicole R. Rutbeek, Freddie J. O. Martin, Ivo Alexander Hendriks, Leighton J. Payne, Yumeng Yan, Dorentina Humolli, Victor Klein-Sousa, Inga Songailiene, Yong Wang, Michael Lund Nielsen, Richard M. Berry, Alexander Harms, Marc Erhardt, Simon A. Jackson, Nicholas M. I. Taylor

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08493-8Structure and mechanism of the Zorya anti-phage defense system

Nature

Publisher Correction: An integrated transcriptomic cell atlas of human neural organoids

mercredi 11 décembre 2024 par Zhisong He, Leander Dony, Jonas Simon Fleck, Artur Sza?ata, Katelyn X. Li, Irena Sliškovi?, Hsiu-Chuan Lin, Malgorzata Santel, Alexander Atamian, Giorgia Quadrato, Jieran Sun, Sergiu P. Pa?ca, Neal D. Amin, Kevin W. Kelley, Taylor Bertucci, Sally Temple, Kathryn R. Bowles, Nicolò Caporale, Emanuele Villa, Giuseppe Testa, Cristiana Cruceanu, Elisabeth B. Binder, J. Gray Camp, Fabian J. Theis, Barbara Treutlein

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08482-xPublisher Correction: An integrated transcriptomic cell atlas of human neural organoids

Nature