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How a biochemistry department used redacted job applications to achieve gender parity

jeudi 12 décembre 2024 par Holly Else
Nature, Published online: 12 December 2024; doi:10.1038/d41586-024-03944-8Anonymizing job applications before shortlisting helped to boost the number of women appointed.

Neanderthals and humans interbred more recently than scientists thought

jeudi 12 décembre 2024 par Freda Kreier
Nature, Published online: 12 December 2024; doi:10.1038/d41586-024-04065-yTwo teams using different methods both conclude that humans and Neanderthals had children together starting roughly 50,000 years ago.

Making kidney tests work for everyone

jeudi 12 décembre 2024 par Liam Drew
Nature, Published online: 12 December 2024; doi:10.1038/d41586-024-04100-yThe United States has moved to deracialize kidney diagnostics. The move addresses major health-equity issues — but it also shines a light on a problematic clinical (...)

Daily briefing: How AI is decoding the calls of the wild

jeudi 12 décembre 2024 par Jacob Smith
Nature, Published online: 12 December 2024; doi:10.1038/d41586-024-04184-6We get a glimpse of a Milky Way-like galaxy in its youth and investigate efforts to use artificial intelligence to decode the ‘language’ of animals.

?-HuB: the proteomic navigator of the human body

mercredi 11 décembre 2024 par Fuchu He, Ruedi Aebersold, Mark S. Baker, Xiuwu Bian, Xiaochen Bo, Daniel W. Chan, Cheng Chang, Luonan Chen, Xiangmei Chen, Yu-Ju Chen, Heping Cheng, Ben C. Collins, Fernando Corrales, Jürgen Cox, Weinan E, Jennifer E. Van Eyk, Jia Fan, Pouya Faridi, Daniel Figeys, George Fu Gao, Wen Gao, Zu-Hua Gao, Keisuke Goda, Wilson Wen Bin Goh, Dongfeng Gu, Changjiang Guo, Tiannan Guo, Yuezhong He, Albert J. R. Heck, Henning Hermjakob, Tony Hunter, Narayanan Gopalakrishna Iyer, Ying Jiang, Connie R. Jimenez, Lokesh Joshi, Neil L. Kelleher, Ming Li, Yang Li, Qingsong Lin, Cui Hua Liu, Fan Liu, Guang-Hui Liu, Yansheng Liu, Zhihua Liu, Teck Yew Low, Ben Lu, Matthias Mann, Anming Meng, Robert L. Moritz, Edouard Nice, Guang Ning, Gilbert S. Omenn, Christopher M. Overall, Giuseppe Palmisano, Yaojin Peng, Charles Pineau, Terence Chuen Wai Poon, Anthony W. Purcell, Jie Qiao, Roger R. Reddel, Phillip J. Robinson, Paola Roncada, Chris Sander, Jiahao Sha, Erwei Song, Sanjeeva Srivastava, Aihua Sun, Siu Kwan Sze, Chao Tang, Liujun Tang, Ruijun Tian, Juan Antonio Vizcaíno, Chanjuan Wang, Chen Wang, Xiaowen Wang, Xinxing Wang, Yan Wang, Tobias Weiss, Mathias Wilhelm, Robert Winkler, Bernd Wollscheid, Limsoon Wong, Linhai Xie, Wei Xie, Tao Xu, Tianhao Xu, Liying Yan, Jing Yang, Xiao Yang, John Yates, Tao Yun, Qiwei Zhai, Bing Zhang, Hui Zhang, Lihua Zhang, Lingqiang Zhang, Pingwen Zhang, Yukui Zhang, Yu Zi Zheng, Qing Zhong, Yunping Zhu, Chris Soon Heng Tan, Mingxia Gao, Qiang Gao, Yushun Gao, Xuejiang Guo, Jie He, Jun He, Qing-Yu He, Jinlin Hou, Canhua Huang, Chenxi Jia, Bernhard Kuster, Chaoying Li, Dong Li, Yan Li, Yanchang Li, Siqi Liu, Xiaonan Liu, Ya Liu, Zhongyang Liu, Haojie Lu, Yongzhan Nie, Mariko Okada, Guojun Qian, Hongqiang Qin, Yu Rao, Zihe Rao, Xianwen Ren, Yan Ren, Feng Shen, Lin Shen, Shicheng Su, Minjia Tan, Ben Zhong Tang, Sheng-Ce Tao, Jian Wang, Tong Wang, Liming Wei, Catherine C. L. Wong, Xiaoliang Sunney Xie, Li Xu, Ping Xu, Huanming Yang, Jianjun Yang, Mingliang Ye, Wantao Ying, Xiaobo Yu, Yaxiang Yuan, Qingcun Zeng, Qimin Zhan, Xiaofei Zhang, Xu Zhang, Ying Zhang, Nan-Shan Zhong, Feng Zhou, Yi Zhu, Zemin Zhang
Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08280-5We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our understanding of human (...)

Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis

mercredi 11 décembre 2024 par Graham W. Heberlig, James J. La Clair, Michael D. Burkart
Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08306-yStructural studies of tyrocidine synthetase using site-selective crosslinking probes to link condensation domains with carrier protein substrates define key interactions and molecular mechanisms of non-ribosomal protein (...)

Continuous collective analysis of chemical reactions

mercredi 11 décembre 2024 par Maowei Hu, Lei Yang, Nathaniel Twarog, Jason Ochoada, Yong Li, Eirinaios I. Vrettos, Arnaldo X. Torres-Hernandez, James B. Martinez, Jiya Bhatia, Brandon M. Young, Jeanine Price, Kevin McGowan, Theresa H. Nguyen, Zhe Shi, Matthew Anyanwu, Mary Ashley Rimmer, Shea Mercer, Zoran Rankovic, Anang A. Shelat, Daniel J. Blair
Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08211-4Mass spectrometry fragmentation patterns define analytical barcodes for the rapid, quantitative analysis of high-throughput chemical synthesis experiments.

Structure and assembly of the dystrophin glycoprotein complex

mercredi 11 décembre 2024 par Li Wan, Xiaofei Ge, Qikui Xu, Gaoxingyu Huang, Tiandi Yang, Kevin P. Campbell, Zhen Yan, Jianping Wu
Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08310-2A structural study of native dystrophin glycoprotein complex from mouse skeletal muscle reveals an extended tower-like architecture that provides multiple binding sites on both sides of the membrane for signalling and (...)

Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor

mercredi 11 décembre 2024 par Mart Reimund, Altaira D. Dearborn, Giorgio Graziano, Haotian Lei, Anthony M. Ciancone, Ashish Kumar, Ronald Holewinski, Edward B. Neufeld, Francis J. O’Reilly, Alan T. Remaley, Joseph Marcotrigiano
Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08223-0Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can give rise to (...)

Large global-scale vegetation sensitivity to daily rainfall variability

mercredi 11 décembre 2024 par Andrew F. Feldman, Alexandra G. Konings, Pierre Gentine, Mitra Cattry, Lixin Wang, William K. Smith, Joel A. Biederman, Abhishek Chatterjee, Joanna Joiner, Benjamin Poulter
Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08232-zSatellite data and field observations show that global annual-scale vegetation indices are sensitive to the daily frequency and intensity of rainfall, independent of the total amount of rainfall per (...)

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