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De novo design of cysteine proteases

mercredi 14 octobre 2026 par Hojae Choi, Magnus S. Bauer, Brian Coventry, Preetham Venkatesh, Anqi Chen, Donghyo Kim, Asim K. Bera, Alex Kang, Hannah Nguyen, Shayan Sadre, Justin Decarreau, Emily Joyce, Bhanumathi Shankaran, Tuscan Rock Thompson, Gabriel Greenstein, Kieran Didi, Lars L. Schaaf, Jacob Merle Gershon, Alexander F. Shida, Gyu Rie Lee, Donald Hilvert, Samuel J. Pellock, David Baker

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-wDe novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.

Nature

Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades

mercredi 14 octobre 2026 par Máté Pénzes, Máté Winternitz, Ádám I. Horváth, Svetlana Mastitskaya, Usman Awan, Tamás Szimler, Camille Glaser, Carlos Kikuti, Marie Juillé, Leila Heidsieck, Anna Á. Rauscher, Tímea Bálint, Dávid Nagy, Tamás Radovits, Alex Ali Sayour, C. Michael Gibson, Anne Houdusse, Máté Gyimesi, András Málnási-Csizmadia

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11171-6R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction and acute kidney (...)

Nature

Evaluating space-based methane detection through a one-year blind test

mercredi 14 octobre 2026 par Frances E. Reuland, Taylor Adams, Evan D. Sherwin, Sahar H. El Abbadi, Eric A. Kort, Adam R. Brandt

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11115-0A year-long single-blind study shows that multiple satellites can accurately detect and quantify methane point-source emissions.

Nature

Competing mechanisms toughen bcc binary and medium-entropy alloys at 20 K

mercredi 14 octobre 2026 par David H. Cook, Xiaoyu Chen, Michael O’Leary, Satish Rao, Wenqing Wang, Calvin H. Belcher, Madelyn Payne, Pedro Borges, Tung Lik Lee, Arun Devaraj, Mark Asta, Enrique J. Lavernia, Diran Apelian, Andrew M. Minor, Dong Liu, Punit Kumar, Robert O. Ritchie

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11065-7The mechanical properties of medium-entropy alloys at 20 K show a plateau in tensile yield strength and fracture toughness as a function of temperature, with no apparent ductile-to-brittle (...)

Nature

Divergent genomic evolution in astrocytomas and oligodendrogliomas

mercredi 14 octobre 2026 par Tamrin Chowdhury, C. Mircea S. Tesileanu, Emre Kocakavuk, Kevin C. Johnson, Joo Ho Lee, Zeynep Erson-Omay, Chaewon Heo, Kenneth Aldape, Samirkumar B. Amin, Kevin J. Anderson, David M. Ashley, Floris P. Barthel, Jill S. Barnholtz-Sloan, Daniel J. Brat, Andrew R. Brodbelt, Ana Valeria Castro, Elizabeth B. Claus, Jennifer M. Connelly, Joseph F. Costello, Indrani Datta, Carol Elliott, Gaetano Finocchiaro, Pim J. French, Hui K. Gan, Luciano Garofano, Padmaja L. Ghospurkar, Anna Golebiewska, Pranav S. Gundla, Beth Hermes, Chibo Hong, Youri Hoogstrate, Craig Horbinski, Jason T. Huse, Antonio Iavarone, Cihat Karadag, Mustafa Khasraw, Mathilde C. M. Kouwenhoven, Peter S. LaViolette, Kay Li, Allison Lowman, Katy McCortney, Hyo-Eun Moon, Nader Sanai, MacLean P. Nasrallah, H. K. Ng, D. Ryan Ormond, Bethany Kwan, Marta Padovan, Sun Ha Paek, Laila M. Poisson, Sushant Puri, Erica Shen, Shwetal Mehta, Andrew E. Sloan, Wies R. Vallentgoed, Erwin G. Van Meir, Rachael Vaubel, Taylor E. Wade, Annemiek M. E. Walenkamp, Colin Watts, Tobias Weiss, Michael Weller, Pieter Wesseling, Kerryn Westcott, Bart A. Westerman, Gordon Y. Ye, W. K. Alfred Yung, Frederick S. Varn, Roel G. W. Verhaak, Tathiane M. Malta, Hoon Kim, Spyridon Bakas, Fulvio D’Angelo, Simona Migliozzi, John F. de Groot, Anna Lasorella, Keith L. Ligon, Annette M. Molinaro, Simone P. Niclou, Joanna J. Phillips, Ganesh Rao, Guido Reifenberger, Susan C. Short, Peter A. E. Sillevis Smitt, Marion Smits, Hiromichi Suzuki, Adelheid Woehrer, Gelareh Zadeh, Lucy F. Stead, Houtan Noushmehr, Do-Hyun Nam

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11150-xLongitudinal genomic analyses in patients with astrocytoma or oligodendrioglioma suggest that these two types of tumour differ in the mechanisms by which they become resistant to treatment, with astrocytomas accumulating (...)

Nature

Computational design of metalloproteases

mercredi 14 octobre 2026 par Anqi Chen, Kejia Wu, Hojae Choi, Preetham Venkatesh, Samuel J. Pellock, Nikita Hanikel, Hojeong shin, Declan Evans, Kieran Didi, Lars L. Schaaf, Cristina Díaz-Perlas, Brian Coventry, Donghyo Kim, Seth M. Woodbury, Pengfei Ji, Shingo Honda, Asim K. Bera, Hannah Nguyen, Alex Kang, Yanqing Wang, Xinting Li, Stacey Gerben, Lemuel Chang, Xiao Yan, Benjamí Oller-Salvia, Anthony A. Hyman, Donald Hilvert, David Baker

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential (...)

Nature

Parity-dependent coupling of molecular spin chains to a superconductor

mercredi 14 octobre 2026 par Katerina Vaxevani, Jon Ortuzar, Stefano Trivini, Georg Monninger, Dongfei Wang, Manuel Vilas-Varela, Lucía Gómez-Rodrigo, Diego Peña, Jose Ignacio Pascual

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11117-yScanning tunnelling spectroscopy shows that the fractional spin-1/2 end states of molecular Haldane chains couple differently to a superconducting condensate depending on whether the chain contains an even or odd number of (...)

Nature

Modelling mouse embryogenesis from chemically induced totipotent stem cells

mercredi 14 octobre 2026 par Hua Wu, Yanyan Hu, Hanzhi Yu, Nana Huang, Lu Shi, Menghan Gao, Xinghan Du, Xue Lu, Yuxia Zhang, Xiya Sun, Xiaoqing Xu, Zhimin Liu, Junsong Yuan, Wei Zhou, Qiliang Shao, Dan Wang, Yangyu Zhao, Tianhua Ma, Sheng Ding

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11164-5A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation, haematopoiesis and early (...)

Nature

Elp1 is required for myeloid differentiation and brain repopulation

mercredi 14 octobre 2026 par Marius Marc-Daniel Mader, Wanhua Li, Alexa Scavetti, Yongjin Yoo, Gernot Neumayer, Katie Han, Yohei Shibuya, Michael Haney, Tony Wyss-Coray, Lynn George, Frances Lefcort, Michael Bassik, Hiromitsu Nakauchi, Adam C. Wilkinson, Marius Wernig

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11112-3Primary cultured haematopoietic stem and progenitor cells are used to analyse the molecular mechanisms of brain myeloid differentiation, and this platform enabled the identification of elongation factor ELP1 as an (...)

Nature

China’s extraordinary rise in science and how it will change the world

mercredi 14 octobre 2026 par Xiaoying You

Nature, Published online: 14 October 2026; doi:10.1038/d41586-026-03222-9The nation is on a trajectory to lead the world in science, a development that will reshape technological advancement, innovation and the balance of global (...)

Nature