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< Les bienfaits des arbres n'ont pas d'origine

mercredi 21 octobre 2020 — Vie et Terre
Les arbres implantés dans les espaces urbains rendent des services à l'environnement -réduisent la pollution et le bruit, servent de ressources et d'abris pour d'autres espèces, réduisent la...

C Chemin de fer

mercredi 21 octobre 2020 — Transports
Le chemin de fer est un système de transport guidé servant au transport de personnes et de marchandises. Il se...

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

mercredi 21 octobre 2020 par Shun Li, Ming Liu, Mytrang H. Do, Chun Chou, Efstathios G. Stamatiades, Briana G. Nixon, Wei Shi, Xian Zhang, Peng Li, Shengyu Gao, Kristelle J. Capistrano, Hong Xu, Nai-Kong V. Cheung, Ming O. Li
Nature, Published online: 21 October 2020; doi:10.1038/s41586-020-2850-34T-Trap, a bispecific molecule designed to recognize CD4 and bind TGF-β, blocks TGF-β signalling in T helper cells, causing interleukin-4-dependent vascular reorganization and cancer cell death in a mouse model of breast (...)

Integrated multi-wavelength control of an ion qubit

mercredi 21 octobre 2020 par R. J. Niffenegger, J. Stuart, C. Sorace-Agaskar, D. Kharas, S. Bramhavar, C. D. Bruzewicz, W. Loh, R. T. Maxson, R. McConnell, D. Reens, G. N. West, J. M. Sage, J. Chiaverini
Nature, Published online: 21 October 2020; doi:10.1038/s41586-020-2811-xA surface-electrode ion-trap chip is demonstrated, which delivers all the wavelengths of light required for the preparation and operation of ion qubits.

DNA mismatches reveal conformational penalties in protein–DNA recognition

mercredi 21 octobre 2020 par Ariel Afek, Honglue Shi, Atul Rangadurai, Harshit Sahay, Alon Senitzki, Suela Xhani, Mimi Fang, Raul Salinas, Zachery Mielko, Miles A. Pufall, Gregory M. K. Poon, Tali E. Haran, Maria A. Schumacher, Hashim M. Al-Hashimi, Raluca Gordân
Nature, Published online: 21 October 2020; doi:10.1038/s41586-020-2843-2A high-throughput assay that introduces mismatched base pairs into the DNA sequence shows that mismatches can increase transcription factor binding affinity by prepaying some of the energetic cost of distorting the (...)

TGF-β suppresses type 2 immunity to cancer

mercredi 21 octobre 2020 par Ming Liu, Fengshen Kuo, Kristelle J. Capistrano, Davina Kang, Briana G. Nixon, Wei Shi, Chun Chou, Mytrang H. Do, Efstathios G. Stamatiades, Shengyu Gao, Shun Li, Yingbei Chen, James J. Hsieh, A. Ari Hakimi, Ichiro Taniuchi, Timothy A. Chan, Ming O. Li
Nature, Published online: 21 October 2020; doi:10.1038/s41586-020-2836-1Depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4+ T cells results in IL-4-dependent vascular remodelling, stopping tumour growth in a transgenic mouse model of breast cancer, suggesting that type 2 (...)

How to get more women and people of colour into graduate school — and keep them there

mercredi 21 octobre 2020 par Sibrina N. Collins
Nature, Published online: 21 October 2020; doi:10.1038/d41586-020-02940-yCase studies show that efforts to address equity in science are doomed if they don’t learn from past mistakes.

Brrrr! ‘Supercooled’ waters make nearby Antarctic seas seem balmy

mercredi 21 octobre 2020
Nature, Published online: 21 October 2020; doi:10.1038/d41586-020-02956-4Elephant seals help to show that tongues of ultra-frigid seawater are relatively common in the Southern Ocean.

Single-particle cryo-EM at atomic resolution

mercredi 21 octobre 2020 par Takanori Nakane, Abhay Kotecha, Andrija Sente, Greg McMullan, Simonas Masiulis, Patricia M. G. E. Brown, Ioana T. Grigoras, Lina Malinauskaite, Tomas Malinauskas, Jonas Miehling, Tomasz Uchański, Lingbo Yu, Dimple Karia, Evgeniya V. Pechnikova, Erwin de Jong, Jeroen Keizer, Maarten Bischoff, Jamie McCormack, Peter Tiemeijer, Steven W. Hardwick, Dimitri Y. Chirgadze, Garib Murshudov, A. Radu Aricescu, Sjors H. W. Scheres
Nature, Published online: 21 October 2020; doi:10.1038/s41586-020-2829-0Advances in electron cryo-microscopy hardware allow proteins to be studied at atomic resolution.

The science behind an 'uncrushable' beetle’s exoskeleton

mercredi 21 octobre 2020 par Benjamin Thompson, Shamini Bundell
Nature, Published online: 21 October 2020; doi:10.1038/d41586-020-02977-zThe structure of a beetle’s super-strong exoskeleton could open up new engineering applications, and efforts to address diversity and equality imbalances in (...)

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