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In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor

mercredi 11 décembre 2024 par Huaipeng Xing, Remus R. E. Rosenkranz, Piere Rodriguez-Aliaga, Ting-Ting Lee, Tomáš Majtner, Stefanie Böhm, Beata Turo?ová, Judith Frydman, Martin Beck

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08321-zTRiC functions at near full occupancy to fold newly synthesized proteins inside cells.

Nature

A lipid made by tumour cells reprograms immune cells

mercredi 11 décembre 2024 par Anthony C. Buzzai, Thomas Tüting

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03855-8Cancer cells often become unresponsive to multiple types of therapy. It emerges that these ‘cross-resistant’ tumour cells release lipids that reprogram cells called monocytes to stop them from activating tumour-targeting T (...)

Nature

Lipid-delivery system could treat life-threatening pregnancy complication

mercredi 11 décembre 2024 par Ravi Thadhani, S. Ananth Karumanchi

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03853-wPre-eclampsia is a common and dangerous pregnancy-related illness. Using tiny lipid particles to deliver messenger RNA directly to the placenta to boost blood-vessel function might prove to be an effective (...)

Nature

Imaging a new class of magnetism

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04030-9Using X-ray microscopy, the properties of a new class of magnetism — altermagnetism — have been explored in prototypical crystal material, manganese telluride. A range of magnetic textures, including exotic vortices, have (...)

Nature

Targeted mRNA therapy tackles deadly pregnancy condition in mice

mercredi 11 décembre 2024 par Nick Petri? Howe, Emily Bates

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04097-4Treatment delivered directly to the placenta restores normal blood pressure in mice, a way to make custom cellular switches, and a milestone for quantum (...)

Nature

Distant sparkles hint at how the Milky Way formed

mercredi 11 décembre 2024 par Brian Welch

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03849-6The JWST has captured images of the Firefly Sparkle — a galaxy that resembles an early Milky Way — in the process of being assembled from star clusters. The discovery could help to reveal how the Milky Way formed in the (...)

Nature

Bone repair supported by flexible films made using an innovative method

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04033-6A scalable strategy for fabricating high-performance films of 2D inorganic materials called MXenes has been developed. The resulting MXene films show excellent performance in guiding bone regeneration and in other (...)

Nature

X-ray method takes a 3D fingerprint of materials

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04036-3A material’s properties are determined by its composition and microstructure — the distribution and orientation of its building blocks. A non-destructive imaging technique has been developed that measures local variations (...)

Nature

A gut fungus protects mice against parasitic worms but increases allergies

mercredi 11 décembre 2024 par Suzanne Noble

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03651-4It has been hard to find fungi that normally reside in the mouse gut. The identification of one such fungus deepens our understanding of how resident fungi drive immune responses in their natural (...)

Nature

Constraint reveals the mitochondrial genome sites most important for health and disease

mercredi 11 décembre 2024

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04039-0Mitochondrial DNA (mtDNA) is the part of the genome found in mitochondria, the ‘powerhouses’ of the cell. An analysis of mitochondrial genomes from nearly 60,000 people shows where selection has removed deleterious genetic (...)

Nature