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Thousands of conductance levels in memristors integrated on CMOS

mercredi 29 mars 2023 par Mingyi Rao, Hao Tang, Jiangbin Wu, Wenhao Song, Max Zhang, Wenbo Yin, Ye Zhuo, Fatemeh Kiani, Benjamin Chen, Xiangqi Jiang, Hefei Liu, Hung-Yu Chen, Rivu Midya, Fan Ye, Hao Jiang, Zhongrui Wang, Mingche Wu, Miao Hu, Han Wang, Qiangfei Xia, Ning Ge, Ju Li, J. Joshua Yang

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05759-5Chips with 256 × 256 memristor arrays that were monolithically integrated on complementary metal–oxide–semiconductor (CMOS) circuits in a commercial foundry achieved 2,048 conductance levels in individual (...)

Nature

Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase

mercredi 29 mars 2023 par Weiran Ge, Cong Yu, Jingjing Li, Zhenyu Yu, Xiaorong Li, Yan Zhang, Chao-Pei Liu, Yingfeng Li, Changlin Tian, Xinzheng Zhang, Guohong Li, Bing Zhu, Rui-Ming Xu

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05841-yThe cryo-electron microscopy structure of the Polycomb repressive deubiquitinase (PR-DUB) in complex with the H2AK119ub1 nucleosome provides insight into how the substrate specificity of PR-DUB is (...)

Nature

Forming intracluster gas in a galaxy protocluster at a redshift of 2.16

mercredi 29 mars 2023 par Luca Di Mascolo, Alexandro Saro, Tony Mroczkowski, Stefano Borgani, Eugene Churazov, Elena Rasia, Paolo Tozzi, Helmut Dannerbauer, Kaustuv Basu, Christopher L. Carilli, Michele Ginolfi, George Miley, Mario Nonino, Maurilio Pannella, Laura Pentericci, Francesca Rizzo

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05761-xAnalysis of observations from the Atacama Large Millimeter/submillimeter Array showed evidence of the thermal Sunyaev–Zeldovich effect in the direction of the Spiderweb protocluster at a redshift of (...)

Nature

Entwined African and Asian genetic roots of medieval peoples of the Swahili coast

mercredi 29 mars 2023 par Esther S. Brielle, Jeffrey Fleisher, Stephanie Wynne-Jones, Kendra Sirak, Nasreen Broomandkhoshbacht, Kim Callan, Elizabeth Curtis, Lora Iliev, Ann Marie Lawson, Jonas Oppenheimer, Lijun Qiu, Kristin Stewardson, J. Noah Workman, Fatma Zalzala, George Ayodo, Agness O. Gidna, Angela Kabiru, Amandus Kwekason, Audax Z. P. Mabulla, Fredrick K. Manthi, Emmanuel Ndiema, Christine Ogola, Elizabeth Sawchuk, Lihadh Al-Gazali, Bassam R. Ali, Salma Ben-Salem, Thierry Letellier, Denis Pierron, Chantal Radimilahy, Jean-Aimé Rakotoarisoa, Ryan L. Raaum, Brendan J. Culleton, Swapan Mallick, Nadin Rohland, Nick Patterson, Mohammed Ali Mwenje, Khalfan Bini Ahmed, Mohamed Mchulla Mohamed, Sloan R. Williams, Janet Monge, Sibel Kusimba, Mary E. Prendergast, David Reich, Chapurukha M. Kusimba

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05754-wAnalysis of ancient human DNA from the Swahili coast reveals that predominantly African female ancestors and Asian male ancestors formed families after around ad 1000 and lived in elite communities in coastal stone (...)

Nature

Structural mechanisms for regulation of GSDMB pore-forming activity

mercredi 29 mars 2023 par Xiu Zhong, Huan Zeng, Zhiwei Zhou, Ya Su, Hang Cheng, Yanjie Hou, Yang She, Na Feng, Jia Wang, Feng Shao, Jingjin Ding

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05872-5The cryo-EM structure of the GSDMB pore reveals mechanisms by which GSDMB pore-forming activity is regulated by pathogenic bacteria and mRNA splicing.

Nature

Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer

mercredi 29 mars 2023 par Min-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh, George Ye, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Megan T. Hoffman, Aladdin M. Bhuiyan, Jaimie L. Barth, Miranda E. Machacek, Mari Mino-Kenudson, Stephanie K. Dougan, Unmesh Jadhav, Clary B. Clish, Nada Y. Kalaany

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05891-2Pancreatic ductal adenocarcinoma cells show a specific dependency on ornithine aminotransferase-mediated ornithine synthesis from glutamine, providing an opportunity to develop targeted therapies with minimal toxicity for (...)

Nature

Structural basis for GSDMB pore formation and its targeting by IpaH7.8

mercredi 29 mars 2023 par Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma, JengYih Chang, Kunpeng Li, Kangkang Song, Chen Xu, Vijay A. Rathinam, Jianbin Ruan

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05832-zThe authors report the cryogenic electron microscopy structures of human GSDMB in complex with Shigella IpaH7.8 and the GSDMB pore, shedding light on the molecular mechanisms of Shigella IpaH7.8 recognition and targeting of (...)

Nature

Norovirus MLKL-like protein initiates cell death to induce viral egress

mercredi 29 mars 2023 par Guoxun Wang, Di Zhang, Robert C. Orchard, Dustin C. Hancks, Tiffany A. Reese

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05851-wThe murine norovirus NTPase NS3 induces mitochondrial disruption, resulting in cell death, which is required for viral egress.

Nature

Mechanistic formulation of inorganic membranes at the air–liquid interface

mercredi 29 mars 2023 par Chen Zhang, Wanheng Lu, Yingfeng Xu, Kaiyang Zeng, Ghim Wei Ho

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05809-yBy switching the nucleation preferences in aqueous systems of inorganic precursors to bias formation and growth at the air–liquid interface, the mechanistic formation of inorganic membranes from the floating-particle system (...)

Nature

Programmable protein delivery with a bacterial contractile injection system

mercredi 29 mars 2023 par Joseph Kreitz, Mirco J. Friedrich, Akash Guru, Blake Lash, Makoto Saito, Rhiannon K. Macrae, Feng Zhang

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05870-7The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types (...)

Nature