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Genome modelling and design across all domains of life with Evo 2

mercredi 4 mars 2026 par Garyk Brixi, Matthew G. Durrant, Jerome Ku, Mohsen Naghipourfar, Michael Poli, Gwanggyu Sun, Greg Brockman, Daniel Chang, Alison Fanton, Gabriel A. Gonzalez, Samuel H. King, David B. Li, Aditi T. Merchant, Eric Nguyen, Chiara Ricci-Tam, David W. Romero, Jonathan C. Schmok, Ali Taghibakhshi, Anton Vorontsov, Brandon Yang, Myra Deng, Liv Gorton, Nam Nguyen, Nicholas K. Wang, Michael T. Pearce, Elana Simon, Etowah Adams, Zachary J. Amador, Euan A. Ashley, Stephen A. Baccus, Haoyu Dai, Steven Dillmann, Stefano Ermon, Daniel Guo, Michael H. Herschl, Rajesh Ilango, Ken Janik, Amy X. Lu, Reshma Mehta, Mohammad R. K. Mofrad, Madelena Y. Ng, Jaspreet Pannu, Christopher Ré, John St. John, Jeremy Sullivan, Joseph Tey, Ben Viggiano, Kevin Zhu, Greg Zynda, Daniel Balsam, Patrick Collison, Anthony B. Costa, Tina Hernandez-Boussard, Eric Ho, Ming-Yu Liu, Thomas McGrath, Kimberly Powell, Sudarshan Pinglay, Dave P. Burke, Hani Goodarzi, Patrick D. Hsu, Brian L. Hie

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10176-5Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and provides a rich (...)

Nature

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

mercredi 4 mars 2026 par Zhenglin Ji, Ji Gao, Shaocun Zhang, Jiajie Li, Haijing Wu, Jing Yao, Xianqiang Ma, Yue Xin, Yongjie Zhu, Meng Zhao, Zhidan Zhao, Kai Shen, Tao Wu, Xinmin Qian, Juanjuan Wang, Haoran An, Yuxin Li, Wenbo Sun, Qiancheng Zhao, Xiaoying Zhou, Ruiyu Gao, Qinghui Duan, Cuifeng Li, Xiaoke Geng, Ming Yang, Rong Xiao, Juan Liu, Wang Wang, Ji Wang, Yesheng Fu, Jing-Ren Zhang, Xiangjun Chen, Pei Tong, Gong Cheng, Hai Qi, Li Wu, Wenwen Zeng, Qiaoran Xi, Lingqiang Zhang, Yuping Lai, Wei Yang, Yonghui Zhang, Qianjin Lu, Wanli Liu

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10167-6Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and (...)

Nature

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

mercredi 4 mars 2026 par Naiqi Wang, Zhian Chen, Yin Yao, Chenglong Sun, Wei Wei, Lei Sun, Hao Zhang, Feng Li, Daniel Butcher, Shi-Ran Sun, Jialei Gong, Yingxin Celia Jiang, Yanfei Qi, Jingxuan Huang, Sam Nettelfield, Rui Liu, Xiaoyue Zheng, Chenyu Li, Yang Fu, Haoyuan Geng, Limin Zhao, Hongjian Sun, Yang Yang, Yexin Ge, Mehrdad Pazhouhandeh, Christopher K. Barlow, Katherine Joanna Jeppe, Joseph Yunis, Chen Zhu, Yunbo Wei, Xiaowen Liang, Kim Bridle, David M. Frazer, Siok-Keen Tey, Yuhua Li, Zhaohui Yang, Minglei Shu, Zheng Liu, Darrell Crawford, Di Yu

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10193-4The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and monounsaturated fatty acids, highlighting a key role for lipid metabolism and dietary composition in (...)

Nature

Merlin: a computed tomography vision–language foundation model and dataset

mercredi 4 mars 2026 par Louis Blankemeier, Ashwin Kumar, Joseph Paul Cohen, Jiaming Liu, Longchao Liu, Dave Van Veen, Syed Jamal Safdar Gardezi, Hongkun Yu, Magdalini Paschali, Zhihong Chen, Jean-Benoit Delbrouck, Eduardo Reis, Robbie Holland, Cesar Truyts, Christian Bluethgen, Yufu Wu, Long Lian, Malte Engmann Kjeldskov Jensen, Sophie Ostmeier, Maya Varma, Jeya Maria Jose Valanarasu, Zhongnan Fang, Zepeng Huo, Zaid Nabulsi, Diego Ardila, Wei-Hung Weng, Edson Amaro Junior, Neera Ahuja, Jason Fries, Nigam H. Shah, Greg Zaharchuk, Marc Willis, Adam Yala, Andrew Johnston, Robert D. Boutin, Andrew Wentland, Curtis P. Langlotz, Jason Hom, Sergios Gatidis, Akshay S. Chaudhari

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10181-8Merlin, a vision–language foundation model trained on a large dataset of paired CT scans, patient record data and radiology reports, demonstrates strong performance across model architectures, diagnostic and prognostic tasks, (...)

Nature

Microbiota-mediated induction of beige adipocytes in response to dietary cues

mercredi 4 mars 2026 par Takeshi Tanoue, Manabu Nagayama, Ayumi J. A. Roochana, Samuel Zimmerman, Orr Ashenberg, Tanvi Jain, Ryo Igarashi, Satoshi Sasajima, Kozue Takeshita, Nicola Hetherington, Nobuyuki Okahashi, Masahiro Ueda, Morichika Konishi, Yoshiaki Nakayama, Aki Minoda, Ashwin N. Skelly, Yasuhiko Minokoshi, Nicholas Pucci, Daniel R. Mende, Makoto Arita, Hironori Yamamoto, Shunji Watanabe, Kouichi Miura, Scott W. Behie, Wataru Suda, Toshiro Sato, Koji Atarashi, Mami Matsushita, Shingo Kajimura, Damian R. Plichta, Masayuki Saito, Ramnik J. Xavier, Kenya Honda

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10205-3In mice, a low-protein diet leads to a gut-microbiota-driven remodelling of adipose tissue towards brown fat, showing that gut microorganisms have a role in detecting and responding to a lack of (...)

Nature

Cell-free chromatin state tracing reveals disease origin and therapy responses

mercredi 4 mars 2026 par Xubin Chen, Xiaoxuan Meng, Weilong Zhang, Xiawei Zhang, Yaping Zhang, Ping Yang, Yan Liu, Fang Bao, Sen Li, Jing Wang, Changjian Yan, Chunyuan Li, Lingke Zhang, Xiaoyu Hao, Jia Liu, Jing Sun, Zhengting Wang, Yu Tian, Liqing Zhu, Yan Hou, Zongchao Liu, Wenqing Li, Lan Mi, Xinyu Qi, Yanzhu Yue, Peng Du, Guoqiang Chen, Junke Zheng, Liping Dou, Hongmei Jing, Aibin He

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10224-0cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of origin and disease (...)

Nature

The oldest articulated bony fish from the early Silurian period

mercredi 4 mars 2026 par You-An Zhu, Yang Chen, Qiang Li, Wen-Jin Zhao, Zheng-Da Zhou, Lian-Tao Jia, Yi-Lun Yu, Han-Xin Yu, Guang-Biao Wei, Per E. Ahlberg, Jing Lu, Min Zhu

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10125-2A tiny, articulated, near-complete osteichthyan from the early Silurian Chongqing Lagerstätte, represents the oldest osteichthyan occurrence including microfossils, and the earliest articulated remains of any bony fish in the (...)

Nature

Bulk hexagonal diamond

mercredi 4 mars 2026 par Shoulong Lai, Xigui Yang, Jiuyang Shi, Shijie Liu, Ying Guo, Longbin Yan, Jinhao Zang, Zhuangfei Zhang, Qiuhan Jia, Jian Sun, Shaobo Cheng, Chongxin Shan

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10212-4The synthesis of millimetre-sized phase-pure hexagonal diamond, a polymorph of cubic diamond, by compressing highly oriented pyrolytic graphite under high pressures and temperatures is reported, providing new insight into (...)

Nature

Sea level much higher than assumed in most coastal hazard assessments

mercredi 4 mars 2026 par Katharina Seeger, Philip S. J. Minderhoud

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10196-1Meta-analyses on a global scale show that the measured coastal mean sea level is higher than assumed in most coastal hazard assessments.

Nature

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding

mercredi 4 mars 2026 par Monica Cassandras, Xavier Sanchez, Lauren Hsu, Yu Huang, Adam J. Getzler, Debolina Ganguly, Pilar Baldominos, Ia Codinachs, Jeffrey Chuong, Elizabeth E. Martin, Blake E. Smith, Eleonora Marina, Milos Spasic, Xingping Qin, Heather A. Parsons, Erica L. Mayer, Kristopher A. Sarosiek, Stephanie K. Dougan, Elizabeth A. Mittendorf, Sandra S. McAllister, Ya-Chieh Hsu, Judith Agudo

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10222-2Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic (...)

Nature