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Temporal uncoupling of radial glia lineage progression in cortical organoids

mercredi 12 août 2026 par Melissa Stouffer, Osvaldo A. Miranda, Florian M. Pauler, Fabrizia Pipicelli, Carmen Streicher, Giselle Cheung, Simon Hippenmeyer

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10916-7RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control (...)

Nature

Shared principles of human and bacterial antiviral immunity

mercredi 12 août 2026 par Philip J. Kranzusch

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10756-5The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector function that reveal (...)

Nature

Cascading continental-scale floods across Europe in 1342–1343

mercredi 12 août 2026 par Andrea Kiss, Alberto Viglione, Mariano Barriendos, Silvia Enzi, Martin Bauch, Kris Decker, Nicolas Maughan, Dag Retsö, Astrid Ogilvie, Miriam Bertola, Tim Soens, Libor Elleder, Rudolf Brázdil, Kathleen Pribyl, Juraj Parajka, Ioannis Telelis, Inês Amorim, Josep Barriendos, Oliver Böhm, Gerardo Benito, Chiara Bertolin, Dario Camuffo, Denis Coeur, Gaston Demarée, Radoslaw Doktor, Markus Dotterweich, Rüdiger Glaser, Jürgen Komma, Neil Macdonald, Hrvoje Petri?, Christian Rohr, Petra Schmocker-Fackel, Lothar Schulte, Willem H. J. Toonen, Oliver Wetter, Günter Blöschl

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10888-8Tracing cascading continental-scale medieval megafloods across Europe indicates that current flood management is unprepared for such sequences, highlighting the urgent need for proactive flood risk management strategies (...)

Nature

Rb-driven transcription limits its tumour-suppressive effects in breast cancer

mercredi 12 août 2026 par April C. Watt, Antonio Ahn, Catherine Blyth, Julia R. Dixon-Douglas, Krutika Ambani, Rhiannon Coulson, Michael Taylor, Keefe T. Chan, Catherine Dietrich, Brendan E. Russ, Susanne Ramm, Christabella A. Mahendra, Kun-Hui Lu, Nichelle Pires, Jesus Garcia-Sannicolas, Olivia Voulgaris, Sheena Nunag, Ching-Seng Ang, Mark A. Dawson, Elgene Lim, Monica Arnedos, Sarat Chandarlapaty, Fabrice André, Shom Goel

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-wCDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle (...)

Nature

Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders

mercredi 12 août 2026 par Yu-Tzu Shih, Jason Bondoc Alipio, Zin-Juan Klaft, Nathaniel Green, Alok Nath Mohapatra, Travis D. Goode, Muthu Panchanatham, Devesh Pathak, Lai Ping Wong, Ruslan Sadreyev, Jung Ho Hyun, Omar Ahmed, Chris Dulla, Amar Sahay

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10907-8Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses (...)

Nature

A gas-enshrouded and gas-reddened black hole at cosmic dawn

mercredi 12 août 2026 par Rohan P. Naidu, Jorryt Matthee, Harley Katz, Anna de Graaff, Pascal A. Oesch, Aaron Smith, Jenny E. Greene, Gabriel Brammer, Andrea Weibel, Raphael Hviding, John Chisholm, Ivo Labbé, Robert A. Simcoe, Callum Witten, Wendy Q. Sun, Hakim Atek, Josephine F. W. Baggen, Sirio Belli, Rachel Bezanson, Leindert A. Boogaard, Sownak Bose, Rychard J. Bouwens, Alba Covelo-Paz, Pratika Dayal, Yoshinobu Fudamoto, Lukas J. Furtak, Emma Giovinazzo, Andy Goulding, Max Gronke, Kasper E. Heintz, Michaela Hirschmann, Garth Illingworth, Akio K. Inoue, Benjamin D. Johnson, Joel Leja, Ecaterina Leonova, Ian McConachie, Michael V. Maseda, Priyamvada Natarajan, Erica Nelson, David J. Setton, Irene Shivaei, David Sobral, Mauro Stefanon, Sandro Tacchella, Sune Toft, Alberto Torralba, Pieter van Dokkum, Arjen van der Wel, Marta Volonteri, Fabian Walter, Bingjie Wang, Darach Watson, Katherine Whitaker

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10846-4Observations of an unusual cosmic-dawn source illuminate how early supermassive black holes may have grown rapidly in a gas-enshrouded state; such enshrouded black holes may lie at the heart of the 'little red (...)

Nature

Towards an equitable future of global photovoltaic waste recycling

mercredi 12 août 2026 par Chen Wang, Jian Zuo, Xinyu Chen, Ruidong Chang, Pengfei Yuan, Kuishuang Feng, Yu Xin, Xi Liu, Peipei Tian, Jing Li, John Laurence Esguerra, Jiashuo Li

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10905-wGlobal photovoltaic waste will reach 297–402 million tonnes by 2060, and regionally adapted recycling strategies and international cooperation will be needed to provide equitable and scalable PV waste (...)

Nature

Luminescent-reaction-enabled super-resolution imaging

mercredi 12 août 2026 par Wenxin Zhu, Chi Zhang, Jiahui Gui, Yibo Yang, Yuxin Wan, Xin Wang, Liying Qu, Ao Guo, Ziqing Zhang, Zhenqian Han, Weisong Zhao, Jiandong Feng

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10889-7A new chemistry-based super-resolution imaging framework is described, enabling 3D, laser-free, highly sensitive and ultralong-term imaging of live cells which overcomes the limitations in spatiotemporal resolution (...)

Nature

Degree-of-polarization modulation for high-dimensional optical computing

mercredi 12 août 2026 par Alessandro Petrini, Claudio Conti, Davide Pierangeli

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10891-zBy engineering the statistics of light at the micrometre scale using phase-only spatial light modulators, both the state and degree of polarization become spatially programmable, enabling direct encoding of information in a (...)

Nature

Structural mechanism governing the directionality of bridge recombination

mercredi 12 août 2026 par Masahiro Hiraizumi, Januka S. Athukoralage, Nicholas T. Perry, Eisuke Tsujimoto, Nami Shiojiri, Naoto Nagahata, Lauren Lee, Gwanggyu Sun, Matthew G. Durrant, Sita S. Chandrasekaran, Silvana Konermann, Keitaro Yamashita, Patrick D. Hsu, Hiroshi Nishimasu

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-yCryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing (...)

Nature