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A human-specific modifier of cortical connectivity and circuit function

mercredi 27 octobre 2021 par Ewoud R. E. Schmidt, Hanzhi T. Zhao, Jung M. Park, Mario Dipoppa, Mauro M. Monsalve-Mercado, Jacob B. Dahan, Chris C. Rodgers, Amélie Lejeune, Elizabeth M. C. Hillman, Kenneth D. Miller, Randy M. Bruno, Franck Polleux
Nature, Published online: 27 October 2021; doi:10.1038/s41586-021-04039-4The human-specific gene duplication SRGAP2C is identified as a modifier of structural and functional features of cortical circuits leading to improved behavioural performance that may have allowed the emergence of (...)

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

mercredi 27 octobre 2021 par Ying Wang, Frederick S. Yen, Xiphias Ge Zhu, Rebecca C. Timson, Ross Weber, Changrui Xing, Yuyang Liu, Benjamin Allwein, Hanzhi Luo, Hsi-Wen Yeh, Søren Heissel, Gokhan Unlu, Eric R. Gamazon, Michael G. Kharas, Richard Hite, Kıvanç Birsoy
Nature, Published online: 27 October 2021; doi:10.1038/s41586-021-04025-wSLC25A39 and its paralogue SLC25A40 have redundant roles in the import of glutathione into mitochondria of mammalian cells.

Cell surface and intracellular auxin signalling for H+ fluxes in root growth

mercredi 27 octobre 2021 par Lanxin Li, Inge Verstraeten, Mark Roosjen, Koji Takahashi, Lesia Rodriguez, Jack Merrin, Jian Chen, Lana Shabala, Wouter Smet, Hong Ren, Steffen Vanneste, Sergey Shabala, Bert De Rybel, Dolf Weijers, Toshinori Kinoshita, William M. Gray, Jiří Friml
Nature, Published online: 27 October 2021; doi:10.1038/s41586-021-04037-6Auxin rapidly modulates root growth through simultaneous activation of two opposing mechanisms—TMK1-mediated apoplast acidification and TIR1/AFB-mediated apoplast (...)

Plan for Africa’s first synchrotron light source starts to crystallize

mercredi 27 octobre 2021 par Sarah Wild
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02938-0Scientists urged to back a plan for a US$1-billion accelerator that could be used to probe the structure of matter and help develop antiviral drugs.

Dentists and doctors need to play on the same team

mercredi 27 octobre 2021 par Shervin Molayem
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02919-3Breaking down the division between mouth and body should lead to better health care.

The mouth’s curative superpowers

mercredi 27 octobre 2021 par Natalie Healey
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02923-7Wounds in the mouth heal faster than in skin — and without scarring. Could unravelling the mechanisms that drive regeneration in the oral cavity lead to better wound (...)

By the numbers: counting the costs of infectious illness

mercredi 27 octobre 2021
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02911-xThe impact of some of the world’s deadliest diseases, and the research effort that goes into them.

A compact device sustains a fluid of bosons

mercredi 27 octobre 2021 par Denis Golež, Zhiyuan Sun
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02876-xA device that generates exotic fluids of particles at equilibrium conditions and high temperatures could have applications ranging from low-loss electrical cables to memory (...)

The audit

mercredi 27 octobre 2021 par Matt Thompson
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02928-2Playing the long game.

The shifting sands of ‘gain-of-function’ research

mercredi 27 octobre 2021 par Amber Dance
Nature, Published online: 27 October 2021; doi:10.1038/d41586-021-02903-xThe mystery of COVID’s origins has reignited a contentious debate about potentially risky studies and the fuzzy terminology that describes them.

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