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Limit of atomic-resolution-tomography reconstruction of amorphous nanoparticles

mercredi 28 janvier 2026 par Robert Busch, Peter Rez, Michael M. J. Treacy, Jian-Min Zuo

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-09924-wA simulation approach is used to ascertain the limitations on the structural and chemical information that atomic-resolution electron tomography can determine from noisy electron (...)

Nature

Vacuum ultraviolet second-harmonic generation in NH₄B₄O₆F crystal

mercredi 28 janvier 2026 par Fangfang Zhang, Zilong Chen, Chen Cui, Zhihua Yang, Miriding Mutailipu, Fuming Li, Xueling Hou, Xifa Long, Shilie Pan

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10007-zThe fluorooxoborate crystal NH4B4O6F shows promise as a nonlinear optical material for vacuum ultraviolet light sources through second-harmonic generation, demonstrating record output energy and efficiency resulting from (...)

Nature

A cross-population compendium of gene–environment interactions

mercredi 28 janvier 2026 par Shinichi Namba, Kyuto Sonehara, Yuriko N. Koyanagi, Takezo Kikuchi, Takafumi Ojima, Ryuya Edahiro, Go Sato, Taiki Yamaji, Yoshihiko Tomofuji, Hiroyuki Ueda, Kenichi Yamamoto, Yosuke Ogawa, Ken Suzuki, Akinori Kanai, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasunobu Nagata, Yasushi Okazaki, Naoyuki Matsumoto, Kenta Motomura, Hidenobu Koga, Asahi Hishida, Hiroaki Ikezaki, Megumi Hara, Mako Nagayoshi, Isao Oze, Shiori Nakano, Yoshiya Oda, Yutaka Suzuki, Motoki Iwasaki, Norie Sawada, Keitaro Matsuo, Takayuki Morisaki, Toshimasa Yamauchi, Takashi Kadowaki, Koichi Matsuda, Yukinori Okada

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10054-6A large cross-population atlas of gene–environment interactions reveals how age, sex and lifestyle shape genetic effects, heritability, prediction accuracy and disease biology, with implications for personalized medicine (...)

Nature

A cavity-array microscope for parallel single-atom interfacing

mercredi 28 janvier 2026 par Adam L. Shaw, Anna Soper, Danial Shadmany, Aishwarya Kumar, Lukas Palm, Da-Yeon Koh, Vassilios Kaxiras, Lavanya Taneja, Matt Jaffe, David I. Schuster, Jonathan Simon

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10035-9A cavity-array microscope is realized using intra-cavity lenses to create a two-dimensional array of over 40 modes, each coupled to a single atom in free-space.

Nature

Advancing regulatory variant effect prediction with AlphaGenome

mercredi 28 janvier 2026 par Žiga Avsec, Natasha Latysheva, Jun Cheng, Guido Novati, Kyle R. Taylor, Tom Ward, Clare Bycroft, Lauren Nicolaisen, Eirini Arvaniti, Joshua Pan, Raina Thomas, Vincent Dutordoir, Matteo Perino, Soham De, Alexander Karollus, Adam Gayoso, Toby Sargeant, Anne Mottram, Lai Hong Wong, Pavol Drotár, Adam Kosiorek, Andrew Senior, Richard Tanburn, Taylor Applebaum, Souradeep Basu, Demis Hassabis, Pushmeet Kohli

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10014-0AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect prediction and (...)

Nature

Robust cytoplasmic partitioning by solving a cytoskeletal instability

mercredi 28 janvier 2026 par Melissa Rinaldin, Alison Kickuth, Adam Lamson, Benjamin Dalton, Yitong Xu, Pavel Mejst?ík, Stefano Di Talia, Jan Brugués

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10023-zThe cytoplasm can be partitioned into distinct compartments by microtubule structures, which can be stabilized by distinct mechanisms in different species.

Nature

A prophage-encoded abortive infection protein preserves host and prophage spread

mercredi 28 janvier 2026 par Molly R. Sargen, Sadie P. Antine, Grzegorz J. Grabe, Gabriella Antonellis, Adelyn E. Ragucci, Yao Li, Philip J. Kranzusch, Sophie Helaine

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10070-6A Gifsy-1 prophage–encoded higher eukaryotes and prokaryotes nucleotide-binding protein, HepS, senses Siphoviridae infection, activates abortive defence by cleaving host transfer RNAs, blocks rival phages and avoids (...)

Nature

Low-power integrated optical amplification through second-harmonic resonance

mercredi 28 janvier 2026 par Devin J. Dean, Taewon Park, Hubert S. Stokowski, Luke Qi, Sam Robison, Alexander Y. Hwang, Jason F. Herrmann, Martin M. Fejer, Amir H. Safavi-Naeini

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-09959-zAn integrated optical parametric amplifier on thin-film lithium niobate achieves more than 17 dB gain with less than 200 mW input power.

Nature

An X-ray-emitting protocluster at z ? 5.7 reveals rapid structure growth

mercredi 28 janvier 2026 par Ákos Bogdán, Gerrit Schellenberger, Qiong Li, Christopher J. Conselice

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-09973-1Discovery of a protocluster at z = 5.68, merely one billion years after the Big Bang, suggests that large-scale structure must have formed more rapidly in some regions of the early universe than previously (...)

Nature

A Cambrian soft-bodied biota after the first Phanerozoic mass extinction

mercredi 28 janvier 2026 par Han Zeng, Qi Liu, Fangchen Zhao, Cui Luo, Dezhi Wang, Yuyan Zhu, Yao Liu, Kai Chen, Zhixin Sun, Yanjie Hong, Lanyun Miao, Chunlin Hu, Haijing Sun, Bing Pan, Jialin Zhao, Zongjun Yin, Guoxiang Li, Xinglian Yang, Aihua Yang, Shixue Hu, Maoyan Zhu

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-10030-0The Huayuan biota exhibits extraordinary biodiversity, illuminating the impact of the Phanerozoic mass extinction around 513 million years ago and offering critical insights into the transformation of global ecosystems in (...)

Nature