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Native American gene flow into Polynesia predating Easter Island settlement

mercredi 8 juillet 2020 par Alexander G. Ioannidis, Javier Blanco-Portillo, Karla Sandoval, Erika Hagelberg, Juan Francisco Miquel-Poblete, J. Víctor Moreno-Mayar, Juan Esteban Rodríguez-Rodríguez, Consuelo D. Quinto-Cortés, Kathryn Auckland, Tom Parks, Kathryn Robson, Adrian V. S. Hill, María C. Avila-Arcos, Alexandra Sockell, Julian R. Homburger, Genevieve L. Wojcik, Kathleen C. Barnes, Luisa Herrera, Soledad Berríos, Mónica Acuña, Elena Llop, Celeste Eng, Scott Huntsman, Esteban G. Burchard, Christopher R. Gignoux, Lucía Cifuentes, Ricardo A. Verdugo, Mauricio Moraga, Alexander J. Mentzer, Carlos D. Bustamante, Andrés Moreno-Estrada
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2487-2Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific (...)

Mitochondrial ubiquinol oxidation is necessary for tumour growth

mercredi 8 juillet 2020 par Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S. McElroy, Marie Werner, Hermon Kihshen, Colleen R. Reczek, Samuel E. Weinberg, Peng Gao, Elizabeth M. Steinert, Raul Piseaux, G. R. Scott Budinger, Navdeep S. Chandel
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2475-6Oxidation of ubiquinol by the mitochondrial electron transfer chain drives tumour growth by maintaining the function of the oxidative Krebs cycle and de novo pyrimidine (...)

How lactate links cannabis to social behaviour

mercredi 8 juillet 2020 par Pierre J. Magistretti
Nature, Published online: 08 July 2020; doi:10.1038/d41586-020-01975-5An active component of cannabis has been shown to disrupt the delicate metabolic balance between neurons and non-neuronal cells called astrocytes, altering social behaviour in (...)

Structures of fungal and plant acetohydroxyacid synthases

mercredi 8 juillet 2020 par Thierry Lonhienne, Yu Shang Low, Mario D. Garcia, Tristan Croll, Yan Gao, Quan Wang, Lou Brillault, Craig M. Williams, James A. Fraser, Ross P. McGeary, Nicholas P. West, Michael J. Landsberg, Zihe Rao, Gerhard Schenk, Luke W. Guddat
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2514-3Structures of fungal and plant acetohydroxyacid synthases

Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila

mercredi 8 juillet 2020 par Sara Mahmoud H. Ahmed, Julieta A. Maldera, Damir Krunic, Gabriela O. Paiva-Silva, Clothilde Pénalva, Aurelio A. Teleman, Bruce A. Edgar
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2462-yHigh levels of the sexually dimorphic hormone ecdysone, produced by active ovaries in Drosophila, promote the proliferation of stem cells in the female gut and maximize reproductive fitness, but also increase female (...)

The six-year-old space agency with hopes for Mars

mercredi 8 juillet 2020 par Shamini Bundell, Nick Howe
Nature, Published online: 08 July 2020; doi:10.1038/d41586-020-02056-3On this week’s podcast, an ambitious Mars mission from a young space agency, and how crumbling up rocks could help fight climate change.

Microbiota modulate sympathetic neurons via a gut–brain circuit

mercredi 8 juillet 2020 par Paul A. Muller, Marc Schneeberger, Fanny Matheis, Putianqi Wang, Zachary Kerner, Anoj Ilanges, Kyle Pellegrino, Josefina del Mármol, Tiago B. R. Castro, Munehiro Furuichi, Matthew Perkins, Wenfei Han, Arka Rao, Amanda J. Picard, Justin R. Cross, Kenya Honda, Ivan de Araujo, Daniel Mucida
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2474-7A combination of gnotobiotic mouse models, transcriptomics, circuit tracing and chemogenetic manipulations identifies neuronal circuits that integrate microbial signals in the gut with regulation of the sympathetic nervous (...)

Massive haplotypes underlie ecotypic differentiation in sunflowers

mercredi 8 juillet 2020 par Marco Todesco, Gregory L. Owens, Natalia Bercovich, Jean-Sébastien Légaré, Shaghayegh Soudi, Dylan O. Burge, Kaichi Huang, Katherine L. Ostevik, Emily B. M. Drummond, Ivana Imerovski, Kathryn Lande, Mariana A. Pascual-Robles, Mihir Nanavati, Mojtaba Jahani, Winnie Cheung, S. Evan Staton, Stéphane Muños, Rasmus Nielsen, Lisa A. Donovan, John M. Burke, Sam Yeaman, Loren H. Rieseberg
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2467-6Resequencing analyses of three species of wild sunflower identify large non-recombining haplotype blocks that correlate with ecologically relevant traits, soil and climate characteristics, and that differentiate species (...)

Potential for large-scale CO2 removal via enhanced rock weathering with croplands

mercredi 8 juillet 2020 par David J. Beerling, Euripides P. Kantzas, Mark R. Lomas, Peter Wade, Rafael M. Eufrasio, Phil Renforth, Binoy Sarkar, M. Grace Andrews, Rachael H. James, Christopher R. Pearce, Jean-Francois Mercure, Hector Pollitt, Philip B. Holden, Neil R. Edwards, Madhu Khanna, Lenny Koh, Shaun Quegan, Nick F. Pidgeon, Ivan A. Janssens, James Hansen, Steven A. Banwart
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2448-9A detailed assessment of the techno-economic potential of enhanced rock weathering on croplands identifies national CO2 removal potentials, costs and engineering challenges if it were to be scaled up to help meet ambitious (...)

Glucose metabolism links astroglial mitochondria to cannabinoid effects

mercredi 8 juillet 2020 par Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez, Charlotte Jollé, Nicole Déglon, Luc Pellerin, Charlène Josephine, Gilles Bonvento, Aude Panatier, Beat Lutz, Pier-Vincenzo Piazza, Manuel Guzmán, Luigi Bellocchio, Anne-Karine Bouzier-Sore, Pedro Grandes, Juan P. Bolaños, Giovanni Marsicano
Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2470-yIn mice, persistent activation of mitochondrial cannabinoid receptors in astroglia impairs cellular glucose metabolism and lactate production, leading to an increase in redox stress in neurons and altered behavioural (...)

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