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Clonal driver neoantigen loss under EGFR TKI and immune selection pressures

mercredi 19 février 2025 par Maise Al Bakir, James L. Reading, Samuel Gamble, Rachel Rosenthal, Imran Uddin, Andrew Rowan, Joanna Przewrocka, Amber Rogers, Yien Ning Sophia Wong, Amalie K. Bentzen, Selvaraju Veeriah, Sophia Ward, Aaron T. Garnett, Paula Kalavakur, Carlos Martínez-Ruiz, Clare Puttick, Ariana Huebner, Daniel E. Cook, David A. Moore, Chris Abbosh, Crispin T. Hiley, Cristina Naceur-Lombardelli, Thomas B. K. Watkins, Marina Petkovic, Roland F. Schwarz, Felipe Gálvez-Cancino, Kevin Litchfield, Peter Meldgaard, Boe Sandahl Sorensen, Line Bille Madsen, Dirk Jäger, Martin D. Forster, Tobias Arkenau, Clara Domingo-Vila, Timothy I. M. Tree, Mohammad Kadivar, Sine Reker Hadrup, Benny Chain, Sergio A. Quezada, Nicholas McGranahan, Charles Swanton

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08586-yWe show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 (...)

Nature

Reply to: Atlantic oceanic droughts do not threaten Asian water tower

mercredi 19 février 2025 par Qiang Zhang, Zexi Shen, Yadu Pokhrel, Daniel Farinotti, Vijay P. Singh, Chong-Yu Xu, Wenhuan Wu, Gang Wang

Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08358-0Reply to: Atlantic oceanic droughts do not threaten Asian water tower

Nature

Publisher Correction: Skin autonomous antibody production regulates host–microbiota interactions

mercredi 19 février 2025 par Inta Gribonika, Victor I. Band, Liang Chi, Paula Juliana Perez-Chaparro, Verena M. Link, Eduard Ansaldo, Cihan Oguz, Djenet Bousbaine, Michael A. Fischbach, Yasmine Belkaid

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08776-8Publisher Correction: Skin autonomous antibody production regulates host–microbiota interactions

Nature

Daily briefing: CAR-T-cell therapy recipient nears two decades in cancer remission

mardi 18 février 2025 par Jacob Smith

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00522-4A woman who received CAR-T-cell therapy has now been in cancer remission for 19 years. Plus, a genetic swap makes mice squeak differently.

Nature

Migraine is more than a headache — a radical rethink offers hope to one billion people

mardi 18 février 2025 par Fred Schwaller

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00456-xDrugs that can prevent or relieve migraine attacks are only effective for some people. Research is starting to untangle the reasons why.

Nature

Molecular glue unexpectedly mimics the effect of cancer mutations

mardi 18 février 2025 par Jonathan W. Bushman, Patrick Ryan Potts

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00090-7Many conventional small-molecule drugs work by inhibiting proteins, affecting their function. One small molecule instead imbues a protein with a new function in a mechanism that could inform rational drug (...)

Nature

Why is it so hard to rewrite a genome?

mardi 18 février 2025 par Michael Eisenstein

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00462-zSynthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.

Nature

Pinpointing neurons that hinder cancer treatment

mardi 18 février 2025 par Ihsan Ekin Demir, Elke Demir

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00501-9Pancreatic tumours hijack neuronal signalling mechanisms to boost cancer growth. A technology to identify and profile mouse neurons that connect the spinal cord to pancreatic cancer might improve treatment of this (...)

Nature