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Envelope protein ubiquitination drives entry and pathogenesis of Zika virus

mercredi 8 juillet 2020 par Maria I. Giraldo, Hongjie Xia, Leopoldo Aguilera-Aguirre, Adam Hage, Sarah van Tol, Chao Shan, Xuping Xie, Gail L. Sturdevant, Shelly J. Robertson, Kristin L. McNally, Kimberly Meade-White, Sasha R. Azar, Shannan L. Rossi, Wendy Maury, Michael Woodson, Holly Ramage, Jeffrey R. Johnson, Nevan J. Krogan, Marc C. Morais, Sonja M. Best, Pei-Yong Shi, Ricardo Rajsbaum

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2457-8The E3 ubiquitin ligase TRIM7 polyubiquitinates the envelope protein of Zika virus, adding Lys63-linked polyubiquitin chains that interact with the TIM1 receptor of host cells to enhance virus entry and (...)

Nature

Scientists make precise gene edits to mitochondrial DNA for first time

mercredi 8 juillet 2020 par Heidi Ledford

Nature, Published online: 08 July 2020; doi:10.1038/d41586-020-02054-5Weird enzyme enables researchers to study — and potentially treat — deadly diseases.

Nature

How to reach another planet when a pandemic is hobbling yours

mercredi 8 juillet 2020

Nature, Published online: 08 July 2020; doi:10.1038/d41586-020-02000-5As the United States, China and the United Arab Emirates head to Mars, they must all commit to sharing what they find.

Nature

Why scientists with children who have disabilities need a different career trajectory

mercredi 8 juillet 2020 par Olivier Pourret

Nature, Published online: 08 July 2020; doi:10.1038/d41586-020-02043-8As lockdowns ease, Olivier Pourret hopes that academia will take on board lessons about how to redefine career success.

Nature

Irritant-evoked activation and calcium modulation of the TRPA1 receptor

mercredi 8 juillet 2020 par Jianhua Zhao, John V. Lin King, Candice E. Paulsen, Yifan Cheng, David Julius

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2480-9Electrophiles activate the transient receptor potential ion channel TRPA1 by a two-step cysteine modification mechanism, which stabilizes a cytoplasmic loop that controls gating and calcium (...)

Nature

In vivo quantification of mitochondrial membrane potential

mercredi 8 juillet 2020 par Nathaniel M. Alpert, Matthieu Pelletier-Galarneau, Yoann Petibon, Marc D. Normandin, Georges El Fakhri

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2366-xIn vivo quantification of mitochondrial membrane potential

Nature

Reply to: In vivo quantification of mitochondrial membrane potential

mercredi 8 juillet 2020 par Milica Momcilovic, Orian Shirihai, Michael P. Murphy, Carla M. Koehler, Saman Sadeghi, David B. Shackelford

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2367-9Reply to: In vivo quantification of mitochondrial membrane potential

Nature

Asymmetric mass ratios for bright double neutron-star mergers

mercredi 8 juillet 2020 par R. D. Ferdman, P. C. C. Freire, B. B. P. Perera, N. Pol, F. Camilo, S. Chatterjee, J. M. Cordes, F. Crawford, J. W. T. Hessels, V. M. Kaspi, M. A. McLaughlin, E. Parent, I. H. Stairs, J. van Leeuwen

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2439-xPulsar timing measurements show a mass ratio of about 0.8 for the double neutron-star system PSR J1913+1102, and population synthesis models indicate that such asymmetric systems represent 2–30% of merging (...)

Nature

Large-scale integration of artificial atoms in hybrid photonic circuits

mercredi 8 juillet 2020 par Noel H. Wan, Tsung-Ju Lu, Kevin C. Chen, Michael P. Walsh, Matthew E. Trusheim, Lorenzo De Santis, Eric A. Bersin, Isaac B. Harris, Sara L. Mouradian, Ian R. Christen, Edward S. Bielejec, Dirk Englund

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2441-3An approach for integrating a large number of solid-state qubits on a photonic integrated circuit is used to construct a 128-channel artificial atom chip containing diamond quantum (...)

Nature

Mitochondrial genome editing gets precise

mercredi 8 juillet 2020 par Magomet Aushev, Mary Herbert

Nature, Published online: 08 July 2020; doi:10.1038/d41586-020-01974-6A bacterial toxin has been found that allows DNA in a cellular organelle called the mitochondrion to be precisely altered. This development could help to combat diseases caused by mutations in mitochondrial (...)

Nature