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Glutamatergic synaptic input to glioma cells drives brain tumour progression

mercredi 18 septembre 2019 par Varun Venkataramani, Dimitar Ivanov Tanev, Christopher Strahle, Alexander Studier-Fischer, Laura Fankhauser, Tobias Kessler, Christoph Körber, Markus Kardorff, Miriam Ratliff, Ruifan Xie, Heinz Horstmann, Mirko Messer, Sang Peter Paik, Johannes Knabbe, Felix Sahm, Felix T. Kurz, Azer Aylin Acikgöz, Frank Herrmannsdörfer, Amit Agarwal, Dwight E. Bergles, Anthony Chalmers, Hrvoje Miletic, Sevin Turcan, Christian Mawrin, Daniel Hänggi, Hai-Kun Liu, Wolfgang Wick, Frank Winkler, Thomas Kuner
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1564-xNeurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.

α-Ketoglutarate links p53 to cell fate during tumour suppression

mercredi 18 septembre 2019 par John P. Morris IV, Jossie J. Yashinskie, Richard Koche, Rohit Chandwani, Sha Tian, Chi-Chao Chen, Timour Baslan, Zoran S. Marinkovic, Francisco J. Sánchez-Rivera, Steven D. Leach, Carlos Carmona-Fontaine, Craig B. Thompson, Lydia W. S. Finley, Scott W. Lowe
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1577-5Restoring the function of p53 in a mouse model of pancreatic ductal adenocarcinoma leads to the accumulation of α-ketoglutarate, which increases levels of the 5-hydroxymethylcytosine chromatin modification and results in (...)

eIF5B gates the transition from translation initiation to elongation

mercredi 18 septembre 2019 par Jinfan Wang, Alex G. Johnson, Christopher P. Lapointe, Junhong Choi, Arjun Prabhakar, Dong-Hua Chen, Alexey N. Petrov, Joseph D. Puglisi
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1561-0Single-molecule dynamics reveal that the GTPase activity of eukaryotic initiation factor eIF5B serves as a kinetic checkpoint for the transition from translation initiation to (...)

Polar research should include Indigenous perspectives

mercredi 18 septembre 2019 par Virginia Gewin
Nature, Published online: 18 September 2019; doi:10.1038/d41586-019-02571-yPat Wongpan explains why polar research must incorporate diverse views, including those of Indigenous peoples and communities affected by climate change.

Dangerous liaisons as tumour cells form synapses with neurons

mercredi 18 septembre 2019 par Andres Barria
Nature, Published online: 18 September 2019; doi:10.1038/d41586-019-02746-7Why brain tumours progress rapidly is unclear. The finding that such cancer cells form synaptic connections with neurons uncovers an interaction that accelerates tumour growth rate and (...)

Radical reform and the Green New Deal

mercredi 18 septembre 2019 par Michael E. Mann
Nature, Published online: 18 September 2019; doi:10.1038/d41586-019-02738-7Michael E. Mann examines Naomi Klein’s collection on the proposed US policy aiming to curb climate change.

FPR1 is the plague receptor on host immune cells

mercredi 18 septembre 2019 par Patrick Osei-Owusu, Thomas M. Charlton, Hwan Keun Kim, Dominique Missiakas, Olaf Schneewind
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1570-zThe receptor FPR1 on human immune cells interacts with Yersinia pestis, mutations in this receptor provide resistance against plague in humans and Fpr1 deficiency enhances survival in (...)

Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis

mercredi 18 septembre 2019 par Cristina Godinho-Silva, Rita G. Domingues, Miguel Rendas, Bruno Raposo, Hélder Ribeiro, Joaquim Alves da Silva, Ana Vieira, Rui M. Costa, Nuno L. Barbosa-Morais, Tânia Carvalho, Henrique Veiga-Fernandes
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1579-3Circadian circuits, entrained by light and tuned by the brain, regulate intestinal group 3 innate lymphoid cells in mice, along with epithelial reactivity, microbiome composition and lipid (...)

Integer factorization using stochastic magnetic tunnel junctions

mercredi 18 septembre 2019 par William A. Borders, Ahmed Z. Pervaiz, Shunsuke Fukami, Kerem Y. Camsari, Hideo Ohno, Supriyo Datta
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1557-9A probabilistic computer utilizing probabilistic bits, or p-bits, is implemented with stochastic nanomagnetic devices in a neural-network-inspired electrical circuit operating at room temperature and demonstrates integer (...)

Synaptic proximity enables NMDAR signalling to promote brain metastasis

mercredi 18 septembre 2019 par Qiqun Zeng, Iacovos P. Michael, Peng Zhang, Sadegh Saghafinia, Graham Knott, Wei Jiao, Brian D. McCabe, José A. Galván, Hugh P. C. Robinson, Inti Zlobec, Giovanni Ciriello, Douglas Hanahan
Nature, Published online: 18 September 2019; doi:10.1038/s41586-019-1576-6Breast-to-brain metastasis is enabled by activation of an N-methyl-d-aspartate receptor, which is achieved via the formation of pseudo-tripartite synapses between cancer cells and glutamatergic (...)

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