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Metabolomics across scales: from single cells to population studies

mercredi 8 avril 2026 par Theodore Alexandrov, Nicola Zamboni

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10277-1This Perspective reviews the potential and the challenges of metabolomics approaches, encompassing both single-cell and population-scale metabolomics.

Nature

Clinical application of base editing for treating ?-thalassaemia

mercredi 8 avril 2026 par Yongrong Lai, Rongrong Liu, Lijie Wang, Xu-Kai Ma, Yaliang Li, Gaohui Yang, Lingling Shi, Yi-Lin Guo, Zhenbin Wei, Xuemei Zhou, Wenchao Xu, Yaofeng Hou, Annarita Miccio, Bei Yang, Xiaodun Mou, Li Yang, Jia Chen

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with (...)

Nature

Mummified early Permian reptile reveals ancient amniote breathing apparatus

mercredi 8 avril 2026 par Robert R. Reisz, Ethan D. Mooney, Tea Maho, David Mazierski, Xu Chu, Joseph J. Bevitt, Yao-Chang Lee, Pei-Yu Huang, Xiaobo Li, Jun Chen

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10307-yA mummified fossil of the early Permian reptile Captorhinus reveals the potential ancestral amniote breathing mechanism and its impact on terrestrial vertebrate (...)

Nature

Multiomics and deep learning dissect regulatory syntax in human development

mercredi 8 avril 2026 par Betty B. Liu, Selin Jessa, Samuel H. Kim, Yan Ting Ng, Soon Il Higashino, Georgi K. Marinov, Derek C. Chen, Benjamin E. Parks, Li Li, Tri C. Nguyen, Austin T. Wang, Sean K. Wang, Meng How Tan, Serena Y. Tan, Michael Kosicki, Len A. Pennacchio, Eyal Ben-David, Anca M. Pasca, Anshul Kundaje, Kyle K. H. Farh, William J. Greenleaf

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10326-9The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific (...)

Nature

Genetic predictors of GLP1 receptor agonist weight loss and side effects

mercredi 8 avril 2026 par Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu, Vinh Tran, R. Ryanne Wu, Catherine H. Weldon, Jingchunzi Shi, Barry Hicks, Robert K. Bell, Katelyn Kukar Bond, Zayn Cochinwala, Sayantan Das, Kahsaia de Brito, Devika Dhamija, Payambr Dibaeinia, Emily DelloRusso, Chris Eijsbouts, Sarah L. Elson, Shirin Fuller, Chris German, Julie M. Granka, Larry Hengl, David A. Hinds, Reza Jabal, Aly Khan, Matthew J. Kmiecik, Alan Kwong, Yanyu Liang, Keng-Han Lin, Matthew H. McIntyre, Alex Moran, Carrie Northover, Shubham Saini, Anjali J. Shastri, Suyash Shringarpure, Teague Sterling, Joyce Y. Tung, Noura S. Abul-Husn, Stella Aslibekyan, Michael V. Holmes, Bertram L. Koelsch, Adam Auton

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10330-zIdentification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of (...)

Nature

The importance of competition and facilitation for global tree diversity

mercredi 8 avril 2026 par Han Xu, Matteo Detto, J. Aaron Hogan, Alfonso Alonso, Joseph D. Birch, Pulchérie Bissiengou, Chengjin Chu, Stuart J. Davies, Gunter A. Fischer, Billy C. H. Hau, David Kenfack, Buhang Li, Juyu Lian, Mingxian Lin, Wande Liu, Yu Liu, Zhifa Liu, James A. Lutz, Hervé Roland Memiaghe, Xiangcheng Mi, Vojtech Novotny, Haibao Ren, Jianrong Su, Jill Thompson, Maria Uriarte, Renato Valencia, Tze Leong Yao, Sandra L. Yap, Yicen Zhang, Jess K. Zimmerman, George D. Weiblen, Yide Li, Suqin Fang, Fangliang He

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10349-2Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, (...)

Nature

Saturation editing of RNU4-2 reveals distinct dominant and recessive disorders

mercredi 8 avril 2026 par Joachim De Jonghe, Hyung Chul Kim, Ayanfeoluwa Adedeji, Elsa Leitão, Ruebena Dawes, Christina M. Kajba, Benjamin Cogné, Yuyang Chen, Alexander J. M. Blakes, Cas Simons, Rocio Rius, Javeria R. Alvi, Florence Amblard, Christina Austin-Tse, Sarah Baer, Elsa V. Balton, Pierre Blanc, Daniel G. Calame, Charles Coutton, Chloe A. Cunningham, Nitsuh Dargie, Katrina M. Dipple, Haowei Du, Salima El Chehadeh, Ian Glass, Joseph G. Gleeson, Olivier Grunewald, Paul Gueguen, Radu Harbuz, Marie-Line Jacquemont, Richard J. Leventer, Pierre Marijon, Olfa Messaoud, Tipu Sultan, Christel Thauvin, Catherine Vincent-Delorme, Elif Yilmaz Gulec, Julien Thevenon, Rodrigo Mendez, Daniel G. MacArthur, Christel Depienne, Caroline Nava, Nicola Whiffin, Gregory M. Findlay

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10334-9Saturation genome editing of RNU4-2 identifies the functional and clinical impact of variants across the entire gene and delineates variants that cause a new recessive neurodevelopmental disorder distinct from ReNU (...)

Nature

Protected quantum gates using qubit doublons in dynamical optical lattices

mercredi 8 avril 2026 par Yann Kiefer, Zijie Zhu, Lars Fischer, Samuel Jele, Marius Gächter, Giacomo Bisson, Konrad Viebahn, Tilman Esslinger

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10285-1A purely geometric two-qubit SWAP gate can be realized by transiently populating qubit doublon states of fermionic atoms in a dynamical optical lattice.

Nature

Biodiversity resilience in a tropical rainforest

mercredi 8 avril 2026 par Timo Metz, Nina Farwig, Carsten F. Dormann, H. Martin Schaefer, Juan E. Guevara Andino, Gunnar Brehm, Santiago Burneo, Anne Chao, Robin L. Chazdon, Robert K. Colwell, Ugo M. Diniz, David A. Donoso, María-José Endara, Santiago Erazo, Sebastián Escobar, Ana Falconí-López, Heike Feldhaar, Mishell Garcia Villamarin, Nina Grella, Katrin Heer, Michael Heethoff, Alexander Keller, Anna R. Landim, Sara D. Leonhardt, Eva Tamargo Lopez, Diego Marín-Armijos, Jörg Müller, Karla Neira-Salamea, Eike Lena Neuschulz, Karen M. Pedersen, Mark-Oliver Rödel, Matthias Schleuning, Thomas Schmitt, Michael Staab, Arianna Tartara, Boris A. Tinoco, Constance J. Tremlett, Marco Tschapka, Sybille Unsicker, Edith Villa-Galaviz, Nico Blüthgen

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10365-2Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity (...)

Nature

Engineered immunosuppressive dendritic cells protect against cardiac remodelling

mercredi 8 avril 2026 par Xiaoying Li, Jiamin Li, Guohua Li, Lisheng Zhu, Guo Cheng, Huanqiang Li, Hao Lin, Ningqing Jia, Xiaoqian Hong, Ye Liu, Zhiwei Zhong, Yize Chen, Biqing Wang, Jing Zhao, Zhenqi Hua, Lingjun Wang, Qiming Chen, Peijie Zheng, Shuyuan Sheng, Songting Gu, Cheng Ni, Shuchang Ye, Changle Ke, Feimu Zhang, Mo Li, Shaohui Shi, Junhua He, Yan Wu, Yinghui Xu, Minjian Kong, Qi Chen, Huajun Li, Yu Zhang, Jianzhong Sun, Guanhua Hu, Chengchen Zhao, Yiping Dong, Lili Yu, Yang Xu, Xinyang Hu

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart (...)

Nature