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A large-scale binding and functional map of human RNA-binding proteins

mercredi 29 juillet 2020 par Eric L. Van Nostrand, Peter Freese, Gabriel A. Pratt, Xiaofeng Wang, Xintao Wei, Rui Xiao, Steven M. Blue, Jia-Yu Chen, Neal A. L. Cody, Daniel Dominguez, Sara Olson, Balaji Sundararaman, Lijun Zhan, Cassandra Bazile, Louis Philip Benoit Bouvrette, Julie Bergalet, Michael O. Duff, Keri E. Garcia, Chelsea Gelboin-Burkhart, Myles Hochman, Nicole J. Lambert, Hairi Li, Michael P. McGurk, Thai B. Nguyen, Tsultrim Palden, Ines Rabano, Shashank Sathe, Rebecca Stanton, Amanda Su, Ruth Wang, Brian A. Yee, Bing Zhou, Ashley L. Louie, Stefan Aigner, Xiang-Dong Fu, Eric Lécuyer, Christopher B. Burge, Brenton R. Graveley, Gene W. Yeo
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2077-3A combination of five assays is used to produce a catalogue of RNA elements to which RNA-binding proteins bind in human cells.

Author Correction: The evolutionary history of lethal metastatic prostate cancer

mercredi 29 juillet 2020 par Gunes Gundem, Peter Van Loo, Barbara Kremeyer, Ludmil B. Alexandrov, Jose M. C. Tubio, Elli Papaemmanuil, Daniel S. Brewer, Heini M. L. Kallio, Gunilla Hägnäs, Matti Annala, Kati Kivinummi, Victoria Goody, Calli Latimer, Sarah O’Meara, Kevin J. Dawson, William Isaacs, Michael R. Emmert-Buck, Matti Nykter, Christopher Foster, Zsofia Kote-Jarai, Douglas Easton, Hayley C. Whitaker, David E. Neal, Colin S. Cooper, Rosalind A. Eeles, Tapio Visakorpi, Peter J. Campbell, Ultan McDermott, David C. Wedge, G. Steven Bova
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2581-5Author Correction: The evolutionary history of lethal metastatic prostate cancer

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

mercredi 29 juillet 2020 par Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg, Florian Kurth, Stefan Hippenstiel, Manuela Dingeldey, Beate Kruse, Florent Fauchere, Emre Baysal, Maike Mangold, Larissa Henze, Roland Lauster, Marcus A. Mall, Kirsten Beyer, Jobst Röhmel, Sebastian Voigt, Jürgen Schmitz, Stefan Miltenyi, Ilja Demuth, Marcel A. Müller, Andreas Hocke, Martin Witzenrath, Norbert Suttorp, Florian Kern, Ulf Reimer, Holger Wenschuh, Christian Drosten, Victor M. Corman, Claudia Giesecke-Thiel, Leif Erik Sander, Andreas Thiel
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2598-9SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Author Correction: The dental proteome of Homo antecessor

mercredi 29 juillet 2020 par Frido Welker, Jazmín Ramos-Madrigal, Petra Gutenbrunner, Meaghan Mackie, Shivani Tiwary, Rosa Rakownikow Jersie-Christensen, Cristina Chiva, Marc R. Dickinson, Martin Kuhlwilm, Marc de Manuel, Pere Gelabert, María Martinón-Torres, Ann Margvelashvili, Juan Luis Arsuaga, Eudald Carbonell, Tomas Marques-Bonet, Kirsty Penkman, Eduard Sabidó, Jürgen Cox, Jesper V. Olsen, David Lordkipanidze, Fernando Racimo, Carles Lalueza-Fox, José María Bermúdez de Castro, Eske Willerslev, Enrico Cappellini
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2580-6Author Correction: The dental proteome of Homo antecessor

Publisher Correction: Extensive signal integration by the phytohormone protein network

mercredi 29 juillet 2020 par Melina Altmann, Stefan Altmann, Patricia A. Rodriguez, Benjamin Weller, Lena Elorduy Vergara, Julius Palme, Nora Marín-de la Rosa, Mayra Sauer, Marion Wenig, José Antonio Villaécija-Aguilar, Jennifer Sales, Chung-Wen Lin, Ramakrishnan Pandiarajan, Veronika Young, Alexandra Strobel, Lisa Gross, Samy Carbonnel, Karl G. Kugler, Antoni Garcia-Molina, George W. Bassel, Claudia Falter, Klaus F. X. Mayer, Caroline Gutjahr, A. Corina Vlot, Erwin Grill, Pascal Falter-Braun
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2585-1Publisher Correction: Extensive signal integration by the phytohormone protein network

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

mercredi 29 juillet 2020 par Ugur Sahin, Petra Oehm, Evelyna Derhovanessian, Robert A. Jabulowsky, Mathias Vormehr, Maike Gold, Daniel Maurus, Doreen Schwarck-Kokarakis, Andreas N. Kuhn, Tana Omokoko, Lena M. Kranz, Mustafa Diken, Sebastian Kreiter, Heinrich Haas, Sebastian Attig, Richard Rae, Katarina Cuk, Alexandra Kemmer-Brück, Andrea Breitkreuz, Claudia Tolliver, Janina Caspar, Juliane Quinkhardt, Lisa Hebich, Malte Stein, Alexander Hohberger, Isabel Vogler, Inga Liebig, Stephanie Renken, Julian Sikorski, Melanie Leierer, Verena Müller, Heidrun Mitzel-Rink, Matthias Miederer, Christoph Huber, Stephan Grabbe, Jochen Utikal, Andreas Pinter, Roland Kaufmann, Jessica C. Hassel, Carmen Loquai, Özlem Türeci
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2537-9Results of an exploratory interim analysis from a phase I trial show that an RNA vaccine targeted towards four melanoma-associated antigens produces durable objective responses in patients with melanoma that are accompanied by (...)

An atlas of dynamic chromatin landscapes in mouse fetal development

mercredi 29 juillet 2020 par David U. Gorkin, Iros Barozzi, Yuan Zhao, Yanxiao Zhang, Hui Huang, Ah Young Lee, Bin Li, Joshua Chiou, Andre Wildberg, Bo Ding, Bo Zhang, Mengchi Wang, J. Seth Strattan, Jean M. Davidson, Yunjiang Qiu, Veena Afzal, Jennifer A. Akiyama, Ingrid Plajzer-Frick, Catherine S. Novak, Momoe Kato, Tyler H. Garvin, Quan T. Pham, Anne N. Harrington, Brandon J. Mannion, Elizabeth A. Lee, Yoko Fukuda-Yuzawa, Yupeng He, Sebastian Preissl, Sora Chee, Jee Yun Han, Brian A. Williams, Diane Trout, Henry Amrhein, Hongbo Yang, J. Michael Cherry, Wei Wang, Kyle Gaulton, Joseph R. Ecker, Yin Shen, Diane E. Dickel, Axel Visel, Len A. Pennacchio, Bing Ren
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2093-3Analysis of chromatin state and accessibility in mouse tissues from twelve sites and eight developmental stages provides a comprehensive view of chromatin dynamics.

When the First Farmers Arrived in Europe, Inequality Evolved

mardi 28 juillet 2020 par Laura Spinney — Features, The Sciences, Evolution
Forests gave way to fields, pushing hunter-gatherers to the margins—geographically and socially -- Read more on ScientificAmerican.com

< Lumière sur la pompe biologique: impact de la bioluminescence

mardi 28 juillet 2020 — Vie et Terre
Dans l'océan, la lumière solaire diminue graduellement dans les premières centaines de mètres, puis l'obscurité devient totale. Dans cet environnement obscur, un des biomes les moins connus de...

C Cuivre

mardi 28 juillet 2020 — Physique
équation[4] : Capacité thermique du solide en J·mol-1·K-1 et température en kelvins, de...

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