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Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

mercredi 29 juillet 2020 par Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P. Geurink, Alexander Wilhelm, Gerbrand J. van der Heden van Noort, Huib Ovaa, Stefan Müller, Klaus-Peter Knobeloch, Krishnaraj Rajalingam, Brenda A. Schulman, Jindrich Cinatl, Gerhard Hummer, Sandra Ciesek, Ivan Dikic
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2601-5Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Author Correction: The evolutionary history of lethal metastatic prostate cancer

mercredi 29 juillet 2020 par Gunes Gundem, Peter Van Loo, Barbara Kremeyer, Ludmil B. Alexandrov, Jose M. C. Tubio, Elli Papaemmanuil, Daniel S. Brewer, Heini M. L. Kallio, Gunilla Hägnäs, Matti Annala, Kati Kivinummi, Victoria Goody, Calli Latimer, Sarah O’Meara, Kevin J. Dawson, William Isaacs, Michael R. Emmert-Buck, Matti Nykter, Christopher Foster, Zsofia Kote-Jarai, Douglas Easton, Hayley C. Whitaker, David E. Neal, Colin S. Cooper, Rosalind A. Eeles, Tapio Visakorpi, Peter J. Campbell, Ultan McDermott, David C. Wedge, G. Steven Bova
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2581-5Author Correction: The evolutionary history of lethal metastatic prostate cancer

Gene therapy could offer an inclusive cure for cystic fibrosis

mercredi 29 juillet 2020 par Roxanne Khamsi
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02111-zAfter three decades of false starts, gene therapy against the disease is in new clinical trials — and there is even hope of a cure.

Rethinking extinctions that arise from habitat loss

mercredi 29 juillet 2020 par Joaquín Hortal, Ana M. C. Santos
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02210-xDoes the loss of species through habitat decline follow the same pattern whether the area lost is part of a large or a small habitat? An analysis sheds light on this long-running debate, with its implications for conservation (...)

Expanded encyclopaedias of DNA elements in the human and mouse genomes

mercredi 29 juillet 2020 par Federico Abascal, Reyes Acosta, Nicholas J. Addleman, Jessika Adrian, Veena Afzal, Bronwen Aken, Jennifer A. Akiyama, Omar Al Jammal, Henry Amrhein, Stacie M. Anderson, Gregory R. Andrews, Igor Antoshechkin, Kristin G. Ardlie, Joel Armstrong, Matthew Astley, Budhaditya Banerjee, Amira A. Barkal, If H. A. Barnes, Iros Barozzi, Daniel Barrell, Gemma Barson, Daniel Bates, Ulugbek K. Baymuradov, Cassandra Bazile, Michael A. Beer, Samantha Beik, M. A. Bender, Ruth Bennett, Louis Philip Benoit Bouvrette, Bradley E. Bernstein, Andrew Berry, Anand Bhaskar, Alexandra Bignell, Steven M. Blue, David M. Bodine, Carles Boix, Nathan Boley, Tyler Borrman, Beatrice Borsari, Alan P. Boyle, Laurel A. Brandsmeier, Alessandra Breschi, Emery H. Bresnick, Jason A. Brooks, Michael Buckley, Christopher B. Burge, Rachel Byron, Eileen Cahill, Lingling Cai, Lulu Cao, Mark Carty, Rosa G. Castanon, Andres Castillo, Hassan Chaib, Esther T. Chan, Daniel R. Chee, Sora Chee, Hao Chen, Huaming Chen, Jia-Yu Chen, Songjie Chen, J. Michael Cherry, Surya B. Chhetri, Jyoti S. Choudhary, Jacqueline Chrast, Dongjun Chung, Declan Clarke, Neal A. L. Cody, Candice J. Coppola, Julie Coursen, Anthony M. D’Ippolito, Stephen Dalton, Cassidy Danyko, Claire Davidson, Jose Davila-Velderrain, Carrie A. Davis, Job Dekker, Alden Deran, Gilberto DeSalvo, Gloria Despacio-Reyes, Colin N. Dewey, Diane E. Dickel, Morgan Diegel, Mark Diekhans, Vishnu Dileep, Bo Ding, Sarah Djebali, Alexander Dobin, Daniel Dominguez, Sarah Donaldson, Jorg Drenkow, Timothy R. Dreszer, Yotam Drier, Michael O. Duff, Douglass Dunn, Catharine Eastman, Joseph R. Ecker, Matthew D. Edwards, Nicole El-Ali, Shaimae I. Elhajjajy, Keri Elkins, Andrew Emili, Charles B. Epstein, Rachel C. Evans, Iakes Ezkurdia, Kaili Fan, Peggy J. Farnham, Nina P. Farrell, Elise A. Feingold, Anne-Maud Ferreira, Katherine Fisher-Aylor, Stephen Fitzgerald, Paul Flicek, Chuan Sheng Foo, Kevin Fortier, Adam Frankish, Peter Freese, Shaliu Fu, Xiang-Dong Fu, Yu Fu, Yoko Fukuda-Yuzawa, Mariateresa Fulciniti, Alister P. W. Funnell, Idan Gabdank, Timur Galeev, Mingshi Gao, Carlos Garcia Giron, Tyler H. Garvin, Chelsea Anne Gelboin-Burkhart, Grigorios Georgolopoulos, Mark B. Gerstein, Belinda M. Giardine, David K. Gifford, David M. Gilbert, Daniel A. Gilchrist, Shawn Gillespie, Thomas R. Gingeras, Peng Gong, Alvaro Gonzalez, Jose M. Gonzalez, Peter Good, Alon Goren, David U. Gorkin, Brenton R. Graveley, Michael Gray, Jack F. Greenblatt, Ed Griffiths, Mark T. Groudine, Fabian Grubert, Mengting Gu, Roderic Guigó, Hongbo Guo, Yu Guo, Yuchun Guo, Gamze Gursoy, Maria Gutierrez-Arcelus, Jessica Halow, Ross C. Hardison, Matthew Hardy, Manoj Hariharan, Arif Harmanci, Anne Harrington, Jennifer L. Harrow, Tatsunori B. Hashimoto, Richard D. Hasz, Meital Hatan, Eric Haugen, James E. Hayes, Peng He, Yupeng He, Nastaran Heidari, David Hendrickson, Elisabeth F. Heuston, Jason A. Hilton, Benjamin C. Hitz, Abigail Hochman, Cory Holgren, Lei Hou, Shuyu Hou, Yun-Hua E. Hsiao, Shanna Hsu, Hui Huang, Tim J. Hubbard, Jack Huey, Timothy R. Hughes, Toby Hunt, Sean Ibarrientos, Robbyn Issner, Mineo Iwata, Osagie Izuogu, Tommi Jaakkola, Nader Jameel, Camden Jansen, Lixia Jiang, Peng Jiang, Audra Johnson, Rory Johnson, Irwin Jungreis, Madhura Kadaba, Maya Kasowski, Mary Kasparian, Momoe Kato, Rajinder Kaul, Trupti Kawli, Michael Kay, Judith C. Keen, Sunduz Keles, Cheryl A. Keller, David Kelley, Manolis Kellis, Pouya Kheradpour, Daniel Sunwook Kim, Anthony Kirilusha, Robert J. Klein, Birgit Knoechel, Samantha Kuan, Michael J. Kulik, Sushant Kumar, Anshul Kundaje, Tanya Kutyavin, Julien Lagarde, Bryan R. Lajoie, Nicole J. Lambert, John Lazar, Ah Young Lee, Donghoon Lee, Elizabeth Lee, Jin Wook Lee, Kristen Lee, Christina S. Leslie, Shawn Levy, Bin Li, Hairi Li, Nan Li, Xiangrui Li, Yang I. Li, Ying Li, Yining Li, Yue Li, Jin Lian, Maxwell W. Libbrecht, Shin Lin, Yiing Lin, Dianbo Liu, Jason Liu, Peng Liu, Tingting Liu, X. Shirley Liu, Yan Liu, Yaping Liu, Maria Long, Shaoke Lou, Jane Loveland, Aiping Lu, Yuheng Lu, Eric Lécuyer, Lijia Ma, Mark Mackiewicz, Brandon J. Mannion, Michael Mannstadt, Deepa Manthravadi, Georgi K. Marinov, Fergal J. Martin, Eugenio Mattei, Kenneth McCue, Megan McEown, Graham McVicker, Sarah K. Meadows, Alex Meissner, Eric M. Mendenhall, Christopher L. Messer, Wouter Meuleman, Clifford Meyer, Steve Miller, Matthew G. Milton, Tejaswini Mishra, Dianna E. Moore, Helen M. Moore, Jill E. Moore, Samuel H. Moore, Jennifer Moran, Ali Mortazavi, Jonathan M. Mudge, Nikhil Munshi, Rabi Murad, Richard M. Myers, Vivek Nandakumar, Preetha Nandi, Anil M. Narasimha, Aditi K. Narayanan, Hannah Naughton, Fabio C. P. Navarro, Patrick Navas, Jurijs Nazarovs, Jemma Nelson, Shane Neph, Fidencio Jun Neri, Joseph R. Nery, Amy R. Nesmith, J. Scott Newberry, Kimberly M. Newberry, Vu Ngo, Rosy Nguyen, Thai B. Nguyen, Tung Nguyen, Andrew Nishida, William S. Noble, Catherine S. Novak, Eva Maria Novoa, Briana Nuñez, Charles W. O’Donnell, Sara Olson, Kathrina C. Onate, Ericka Otterman, Hakan Ozadam, Michael Pagan, Tsultrim Palden, Xinghua Pan, Yongjin Park, E. Christopher Partridge, Benedict Paten, Florencia Pauli-Behn, Michael J. Pazin, Baikang Pei, Len A. Pennacchio, Alexander R. Perez, Emily H. Perry, Dmitri D. Pervouchine, Nishigandha N. Phalke, Quan Pham, Doug H. Phanstiel, Ingrid Plajzer-Frick, Gabriel A. Pratt, Henry E. Pratt, Sebastian Preissl, Jonathan K. Pritchard, Yuri Pritykin, Michael J. Purcaro, Qian Qin, Giovanni Quinones-Valdez, Ines Rabano, Ernest Radovani, Anil Raj, Nisha Rajagopal, Oren Ram, Lucia Ramirez, Ricardo N. Ramirez, Dylan Rausch, Soumya Raychaudhuri, Joseph Raymond, Rozita Razavi, Timothy E. Reddy, Thomas M. Reimonn, Bing Ren, Alexandre Reymond, Alex Reynolds, Suhn K. Rhie, John Rinn, Miguel Rivera, Juan Carlos Rivera-Mulia, Brian S. Roberts, Jose Manuel Rodriguez, Joel Rozowsky, Russell Ryan, Eric Rynes, Denis N. Salins, Richard Sandstrom, Takayo Sasaki, Shashank Sathe, Daniel Savic, Alexandra Scavelli, Jonathan Scheiman, Christoph Schlaffner, Jeffery A. Schloss, Frank W. Schmitges, Lei Hoon See, Anurag Sethi, Manu Setty, Anthony Shafer, Shuo Shan, Eilon Sharon, Quan Shen, Yin Shen, Richard I. Sherwood, Minyi Shi, Sunyoung Shin, Noam Shoresh, Kyle Siebenthall, Cristina Sisu, Teri Slifer, Cricket A. Sloan, Anna Smith, Valentina Snetkova, Michael P. Snyder, Damek V. Spacek, Sharanya Srinivasan, Rohith Srivas, George Stamatoyannopoulos, John A. Stamatoyannopoulos, Rebecca Stanton, Dave Steffan, Sandra Stehling-Sun, J. Seth Strattan, Amanda Su, Balaji Sundararaman, Marie-Marthe Suner, Tahin Syed, Matt Szynkarek, Forrest Y. Tanaka, Danielle Tenen, Mingxiang Teng, Jeffrey A. Thomas, Dave Toffey, Michael L. Tress, Diane E. Trout, Gosia Trynka, Junko Tsuji, Sean A. Upchurch, Oana Ursu, Barbara Uszczynska-Ratajczak, Mia C. Uziel, Alfonso Valencia, Benjamin Van Biber, Arjan G. van der Velde, Eric L. Van Nostrand, Yekaterina Vaydylevich, Jesus Vazquez, Alec Victorsen, Jost Vielmetter, Jeff Vierstra, Axel Visel, Anna Vlasova, Christopher M. Vockley, Simona Volpi, Shinny Vong, Hao Wang, Mengchi Wang, Qin Wang, Ruth Wang, Tao Wang, Wei Wang, Xiaofeng Wang, Yanli Wang, Nathaniel K. Watson, Xintao Wei, Zhijie Wei, Hendrik Weisser, Sherman M. Weissman, Rene Welch, Robert E. Welikson, Zhiping Weng, Harm-Jan Westra, John W. Whitaker, Collin White, Kevin P. White, Andre Wildberg, Brian A. Williams, David Wine, Heather N. Witt, Barbara Wold, Maxim Wolf, James Wright, Rui Xiao, Xinshu Xiao, Jie Xu, Jinrui Xu, Koon-Kiu Yan, Yongqi Yan, Hongbo Yang, Xinqiong Yang, Yi-Wen Yang, Galip Gürkan Yardımcı, Brian A. Yee, Gene W. Yeo, Taylor Young, Tianxiong Yu, Feng Yue, Chris Zaleski, Chongzhi Zang, Haoyang Zeng, Weihua Zeng, Daniel R. Zerbino, Jie Zhai, Lijun Zhan, Ye Zhan, Bo Zhang, Jialing Zhang, Jing Zhang, Kai Zhang, Lijun Zhang, Peng Zhang, Qi Zhang, Xiao-Ou Zhang, Yanxiao Zhang, Zhizhuo Zhang, Yuan Zhao, Ye Zheng, Guoqing Zhong, Xiao-Qiao Zhou, Yun Zhu, Jared Zimmerman
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2493-4The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse (...)

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

mercredi 29 juillet 2020 par Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg, Florian Kurth, Stefan Hippenstiel, Manuela Dingeldey, Beate Kruse, Florent Fauchere, Emre Baysal, Maike Mangold, Larissa Henze, Roland Lauster, Marcus A. Mall, Kirsten Beyer, Jobst Röhmel, Sebastian Voigt, Jürgen Schmitz, Stefan Miltenyi, Ilja Demuth, Marcel A. Müller, Andreas Hocke, Martin Witzenrath, Norbert Suttorp, Florian Kern, Ulf Reimer, Holger Wenschuh, Christian Drosten, Victor M. Corman, Claudia Giesecke-Thiel, Leif Erik Sander, Andreas Thiel
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2598-9SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Bacteria-eating viruses could provide a route to stability in cystic fibrosis

mercredi 29 juillet 2020 par Elizabeth Svoboda
Nature, Published online: 29 July 2020; doi:10.1038/d41586-020-02109-7Phage therapy is broadening the treatment landscape for people with drug-resistant infections.

Author Correction: The dental proteome of Homo antecessor

mercredi 29 juillet 2020 par Frido Welker, Jazmín Ramos-Madrigal, Petra Gutenbrunner, Meaghan Mackie, Shivani Tiwary, Rosa Rakownikow Jersie-Christensen, Cristina Chiva, Marc R. Dickinson, Martin Kuhlwilm, Marc de Manuel, Pere Gelabert, María Martinón-Torres, Ann Margvelashvili, Juan Luis Arsuaga, Eudald Carbonell, Tomas Marques-Bonet, Kirsty Penkman, Eduard Sabidó, Jürgen Cox, Jesper V. Olsen, David Lordkipanidze, Fernando Racimo, Carles Lalueza-Fox, José María Bermúdez de Castro, Eske Willerslev, Enrico Cappellini
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2580-6Author Correction: The dental proteome of Homo antecessor

Publisher Correction: Extensive signal integration by the phytohormone protein network

mercredi 29 juillet 2020 par Melina Altmann, Stefan Altmann, Patricia A. Rodriguez, Benjamin Weller, Lena Elorduy Vergara, Julius Palme, Nora Marín-de la Rosa, Mayra Sauer, Marion Wenig, José Antonio Villaécija-Aguilar, Jennifer Sales, Chung-Wen Lin, Ramakrishnan Pandiarajan, Veronika Young, Alexandra Strobel, Lisa Gross, Samy Carbonnel, Karl G. Kugler, Antoni Garcia-Molina, George W. Bassel, Claudia Falter, Klaus F. X. Mayer, Caroline Gutjahr, A. Corina Vlot, Erwin Grill, Pascal Falter-Braun
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2585-1Publisher Correction: Extensive signal integration by the phytohormone protein network

Deep strong light–matter coupling in plasmonic nanoparticle crystals

mercredi 29 juillet 2020 par Niclas S. Mueller, Yu Okamura, Bruno G. M. Vieira, Sabrina Juergensen, Holger Lange, Eduardo B. Barros, Florian Schulz, Stephanie Reich
Nature, Published online: 29 July 2020; doi:10.1038/s41586-020-2508-1Photons and plasmons hybridize into polaritons in three-dimensional crystals of plasmonic nanoparticles, leading to deep strong light–matter coupling and the breakdown of the Purcell (...)

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