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Guarding the gate for mitochondrial entry

mercredi 22 mai 2019 par Sylvie Callegari, Peter Rehling
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01588-7The protein-import systems of organelles can become clogged by proteins. A protein from one organelle, the endoplasmic reticulum, is found to also unclog such blockages in mitochondrial (...)

Superconductivity at 250 K in lanthanum hydride under high pressures

mercredi 22 mai 2019 par A. P. Drozdov, P. P. Kong, V. S. Minkov, S. P. Besedin, M. A. Kuzovnikov, S. Mozaffari, L. Balicas, F. F. Balakirev, D. E. Graf, V. B. Prakapenka, E. Greenberg, D. A. Knyazev, M. Tkacz, M. I. Eremets
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1201-8A lanthanum hydride compound at a pressure of around 170 gigapascals is found to exhibit superconductivity with a critical temperature of 250 kelvin.

The rheology and thermal history of Mars revealed by the orbital evolution of Phobos

mercredi 22 mai 2019 par Henri Samuel, Philippe Lognonné, Mark Panning, Valéry Lainey
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1202-7Insights into the thermal and rheological history of Mars are generated by considering the interplay between the thermochemistry of the planet and the orbital evolution of its closest satellite, (...)

Closing in on what motivates motivation

mercredi 22 mai 2019 par Margaret E. Rice
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01589-6The neurotransmitter dopamine facilitates learning, motivation and movement. Evidence of its release independently of the activity of dopamine-producing neurons in rat brains forces a rethink of dopamine (...)

Genome–lamina interactions are established de novo in the early mouse embryo

mercredi 22 mai 2019 par Máté Borsos, Sara M. Perricone, Tamás Schauer, Julien Pontabry, Kim L. de Luca, Sandra S. de Vries, Elias R. Ruiz-Morales, Maria-Elena Torres-Padilla, Jop Kind
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1233-0Spatial genome organization into lamina-associated domains is first established in the mouse zygote immediately after fertilization without inheritance from the maternal germline—with the paternal and maternal pronucleus (...)

Rogue emissions of ozone-depleting chemical pinned to China

mercredi 22 mai 2019 par Jeff Tollefson
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01647-zFactories in the country’s northeast are likely source of spike in release of CFC-11 gas.

Absence of amorphous forms when ice is compressed at low temperature

mercredi 22 mai 2019 par Chris A. Tulk, Jamie J. Molaison, Adam R. Makhluf, Craig E. Manning, Dennis D. Klug
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1204-5Slow compression of ice at low temperature results in the sequential formation of a series of crystalline phases, challenging theories that connect amorphous ice to supercooled liquid (...)

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

mercredi 22 mai 2019 par Baoyu Zhao, Fenglei Du, Pengbiao Xu, Chang Shu, Banumathi Sankaran, Samantha L. Bell, Mengmeng Liu, Yuanjiu Lei, Xinsheng Gao, Xiaofeng Fu, Fanxiu Zhu, Yang Liu, Arthur Laganowsky, Xueyun Zheng, Jun-Yuan Ji, A. Phillip West, Robert O. Watson, Pingwei Li
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1228-xA molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 (...)

Global change drives modern plankton communities away from the pre-industrial state

mercredi 22 mai 2019 par Lukas Jonkers, Helmut Hillebrand, Michal Kucera
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1230-3Seafloor-derived planktonic foraminifera communities of pre-industrial age are compared with communities from sediment-trap time series and show that Anthropocene communities of a globally distributed zooplankton group differ (...)

A twist in the tale of the structure of ice

mercredi 22 mai 2019 par John S. Tse
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01586-9A classic study found that crystalline ice adopts an amorphous form when compressed. Experiments now find that alternative phase transitions can occur — with implications for theories about water’s (...)

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