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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

mercredi 22 mai 2019 par Baoyu Zhao, Fenglei Du, Pengbiao Xu, Chang Shu, Banumathi Sankaran, Samantha L. Bell, Mengmeng Liu, Yuanjiu Lei, Xinsheng Gao, Xiaofeng Fu, Fanxiu Zhu, Yang Liu, Arthur Laganowsky, Xueyun Zheng, Jun-Yuan Ji, A. Phillip West, Robert O. Watson, Pingwei Li
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1228-xA molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 (...)

Global change drives modern plankton communities away from the pre-industrial state

mercredi 22 mai 2019 par Lukas Jonkers, Helmut Hillebrand, Michal Kucera
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1230-3Seafloor-derived planktonic foraminifera communities of pre-industrial age are compared with communities from sediment-trap time series and show that Anthropocene communities of a globally distributed zooplankton group differ (...)

A twist in the tale of the structure of ice

mercredi 22 mai 2019 par John S. Tse
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01586-9A classic study found that crystalline ice adopts an amorphous form when compressed. Experiments now find that alternative phase transitions can occur — with implications for theories about water’s (...)

Dissociable dopamine dynamics for learning and motivation

mercredi 22 mai 2019 par Ali Mohebi, Jeffrey R. Pettibone, Arif A. Hamid, Jenny-Marie T. Wong, Leah T. Vinson, Tommaso Patriarchi, Lin Tian, Robert T. Kennedy, Joshua D. Berke
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1235-yThe dopamine projection from midbrain dopamine cells to the nucleus accumbens is essential for normal motivation, yet motivation-related changes in nucleus accumbens dopamine release occur independently of dopamine cell (...)

Billion-year-old fossils set back evolution of earliest fungi

mercredi 22 mai 2019 par Heidi Ledford
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01629-1Microscopic specimens discovered in the Canadian Arctic are surprisingly intricate.

Genomic characterization of metastatic breast cancers

mercredi 22 mai 2019 par François Bertucci, Charlotte K. Y. Ng, Anne Patsouris, Nathalie Droin, Salvatore Piscuoglio, Nadine Carbuccia, Jean Charles Soria, Alicia Tran Dien, Yahia Adnani, Maud Kamal, Séverine Garnier, Guillaume Meurice, Marta Jimenez, Semih Dogan, Benjamin Verret, Max Chaffanet, Thomas Bachelot, Mario Campone, Claudia Lefeuvre, Herve Bonnefoi, Florence Dalenc, Alexandra Jacquet, Maria R. De Filippo, Naveen Babbar, Daniel Birnbaum, Thomas Filleron, Christophe Le Tourneau, Fabrice André
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1056-zPatient data from six clinical trials are used to compare the genomic landscapes of breast cancer metastases with those of primary tumours, revealing an increase in mutational burden and clonal (...)

Fast and inefficient star formation due to short-lived molecular clouds and rapid feedback

mercredi 22 mai 2019 par J. M. Diederik Kruijssen, Andreas Schruba, Mélanie Chevance, Steven N. Longmore, Alexander P. S. Hygate, Daniel T. Haydon, Anna F. McLeod, Julianne J. Dalcanton, Linda J. Tacconi, Ewine F. van Dishoeck
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1194-3Observations that molecular gas in NGC 300 is spatially uncorrelated with high-mass stars are attributed to rapid evolution, with molecular clouds quickly destroyed by stellar feedback, and low star-formation (...)

CRISPR-baby rules, fake-news law and kilogram retires

mercredi 22 mai 2019
Nature, Published online: 22 May 2019; doi:10.1038/d41586-019-01564-1The week in science: 17–23 May 2019.

Increase in CFC-11 emissions from eastern China based on atmospheric observations

mercredi 22 mai 2019 par M. Rigby, S. Park, T. Saito, L. M. Western, A. L. Redington, X. Fang, S. Henne, A. J. Manning, R. G. Prinn, G. S. Dutton, P. J. Fraser, A. L. Ganesan, B. D. Hall, C. M. Harth, J. Kim, K.-R. Kim, P. B. Krummel, T. Lee, S. Li, Q. Liang, M. F. Lunt, S. A. Montzka, J. Mühle, S. O’Doherty, M.-K. Park, S. Reimann, P. K. Salameh, P. Simmonds, R. L. Tunnicliffe, R. F. Weiss, Y. Yokouchi, D. Young
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1193-4Emissions from eastern China account for approximately 40 to 60 per cent of the global rise in emissions of trichlorofluoromethane (CFC-11), which may be a result of new production and (...)

A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements

mercredi 22 mai 2019 par Suzanne Z. Andersen, Viktor Čolić, Sungeun Yang, Jay A. Schwalbe, Adam C. Nielander, Joshua M. McEnaney, Kasper Enemark-Rasmussen, Jon G. Baker, Aayush R. Singh, Brian A. Rohr, Michael J. Statt, Sarah J. Blair, Stefano Mezzavilla, Jakob Kibsgaard, Peter C. K. Vesborg, Matteo Cargnello, Stacey F. Bent, Thomas F. Jaramillo, Ifan E. L. Stephens, Jens K. Nørskov, Ib Chorkendorff
Nature, Published online: 22 May 2019; doi:10.1038/s41586-019-1260-xA rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements

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