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Ways to give an effective seminar about your research project

mercredi 15 mai 2019 par Ananya Sen
Nature, Published online: 15 May 2019; doi:10.1038/d41586-019-01574-zGrab your audience’s attention by using slides as a roadmap and focusing on your role as a presenter, recommends Ananya Sen.

An apical hypoxic niche sets the pace of shoot meristem activity

mercredi 15 mai 2019 par Daan A. Weits, Alicja B. Kunkowska, Nicholas C. W. Kamps, Katharina M. S. Portz, Niko K. Packbier, Zoe Nemec Venza, Christophe Gaillochet, Jan U. Lohmann, Ole Pedersen, Joost T. van Dongen, Francesco Licausi
Nature, Published online: 15 May 2019; doi:10.1038/s41586-019-1203-6Hypoxia in the shoot meristem of Arabidopsis links the regulation of metabolic activity to development by inhibiting proteolysis of a substrate of the N-degron pathway, which controls class-III homeodomain-leucine zipper (...)

Springer Nature journals unify their policy to encourage preprint sharing

mercredi 15 mai 2019
Nature, Published online: 15 May 2019; doi:10.1038/d41586-019-01493-zRecognizing the benefits, we move from merely supporting the use of preprint servers to promoting it.

Transcriptional cofactors display specificity for distinct types of core promoters

mercredi 15 mai 2019 par Vanja Haberle, Cosmas D. Arnold, Michaela Pagani, Martina Rath, Katharina Schernhuber, Alexander Stark
Nature, Published online: 15 May 2019; doi:10.1038/s41586-019-1210-7A screen of 23 transcriptional cofactors for their ability to activate 72,000 candidate core promoters in Drosophila melanogaster identified distinct compatibility groups, providing insight into mechanisms that underlie the (...)

Daily briefing: San Francisco bans facial-recognition technology

mercredi 15 mai 2019 par Flora Graham
Nature, Published online: 15 May 2019; doi:10.1038/d41586-019-01559-y“We have an outsize responsibility to regulate the excesses of technology precisely because they are headquartered here.” Plus: ghostwritten peer reviews and mysterious ‘Loki’ (...)

Being a PhD student shouldn’t be bad for your health

mercredi 15 mai 2019
Nature, Published online: 15 May 2019; doi:10.1038/d41586-019-01492-0The first international meeting on postgraduate mental health opens this week, but much more is needed to solve academia’s crisis.

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

mercredi 15 mai 2019 par Federico Gaiti, Ronan Chaligne, Hongcang Gu, Ryan M. Brand, Steven Kothen-Hill, Rafael C. Schulman, Kirill Grigorev, Davide Risso, Kyu-Tae Kim, Alessandro Pastore, Kevin Y. Huang, Alicia Alonso, Caroline Sheridan, Nathaniel D. Omans, Evan Biederstedt, Kendell Clement, Lili Wang, Joshua A. Felsenfeld, Erica B. Bhavsar, Martin J. Aryee, John N. Allan, Richard Furman, Andreas Gnirke, Catherine J. Wu, Alexander Meissner, Dan A. Landau
Nature, Published online: 15 May 2019; doi:10.1038/s41586-019-1198-zA single-cell approach is used to follow the heritable stochastic changes to DNA methylation that occur in primary chronic lymphocytic leukaemia and healthy B cells, allowing the tracing of cell lineage histories and evolution (...)

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy

mercredi 15 mai 2019 par Mauro Di Pilato, Edward Y. Kim, Bruno L. Cadilha, Jasper N. Prüßmann, Mazen N. Nasrallah, Davide Seruggia, Shariq M. Usmani, Sandra Misale, Valentina Zappulli, Esteban Carrizosa, Vinidhra Mani, Matteo Ligorio, Ross D. Warner, Benjamin D. Medoff, Francesco Marangoni, Alexandra-Chloe Villani, Thorsten R. Mempel
Nature, Published online: 15 May 2019; doi:10.1038/s41586-019-1215-2Disruption of the CARMA1–BCL10–MALT1 (CBM) signalosome causes Treg cells to produce IFNγ and develop dominant anti-tumour activity in synergy with anti-PD-1 treatment, and in the absence of (...)

Tracing the origin of adult intestinal stem cells

mercredi 15 mai 2019 par Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H. Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H. Pers, Konstantin Khodosevich, Benjamin D. Simons, Kim B. Jensen
Nature, Published online: 15 May 2019; doi:10.1038/s41586-019-1212-5Lineage tracing, biophysical modelling and intestinal transplantation approaches are used to demonstrate that, in the mouse fetal intestinal epithelium, cells are highly plastic with respect to cellular identity and, (...)

Sampling the volatile-rich transition zone beneath Bermuda

mercredi 15 mai 2019 par Sarah E. Mazza, Esteban Gazel, Michael Bizimis, Robert Moucha, Paul Béguelin, Elizabeth A. Johnson, Ryan J. McAleer, Alexander V. Sobolev
Nature, Published online: 15 May 2019; doi:10.1038/s41586-019-1183-6The formation of Bermuda sampled a previously unknown mantle reservoir that is characterized by silica-undersaturated melts enriched in volatiles and by a unique lead isotopic signature, which suggests that the source is (...)

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