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Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

mercredi 12 juin 2019 par Humayun Sharif, Li Wang, Wei Li Wang, Venkat Giri Magupalli, Liudmila Andreeva, Qi Qiao, Arthur V. Hauenstein, Zhaolong Wu, Gabriel Núñez, Youdong Mao, Hao Wu
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1295-zA cryo-electron microscopy structure of human NLRP3 in complex with the mitotic kinase NEK7 provides insights into the interactions that mediate the activation of the NLRP3 (...)

Mineral protection regulates long-term global preservation of natural organic carbon

mercredi 12 juin 2019 par Jordon D. Hemingway, Daniel H. Rothman, Katherine E. Grant, Sarah Z. Rosengard, Timothy I. Eglinton, Louis A. Derry, Valier V. Galy
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1280-6Broadening activation energy distributions and increasing radiocarbon ages reveal the global importance of mineral protection in promoting organic carbon preservation.

Climate as a risk factor for armed conflict

mercredi 12 juin 2019 par Katharine J. Mach, Caroline M. Kraan, W. Neil Adger, Halvard Buhaug, Marshall Burke, James D. Fearon, Christopher B. Field, Cullen S. Hendrix, Jean-Francois Maystadt, John O’Loughlin, Philip Roessler, Jürgen Scheffran, Kenneth A. Schultz, Nina von Uexkull
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1300-6Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of (...)

Evidence for two blue (type IIb) diamond populations

mercredi 12 juin 2019 par Andy E. Moore, Herwart Helmstaedt
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1245-9Evidence for two blue (type IIb) diamond populations

Superconducting magnet breaks strength world record

mercredi 12 juin 2019 par Davide Castelvecchi
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01869-1Magnet generates an unprecedented 45.5-tesla field.

Whole-body PET scanner produces 3D images in seconds

mercredi 12 juin 2019 par Sara Reardon
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01833-zThe modified scanner also requires less radioactive exposure, vastly broadening its applications.

Hijack of CRISPR defences by selfish genes holds clinical promise

mercredi 12 juin 2019 par Fyodor D. Urnov
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01824-0Parasitic genetic elements called transposons carry CRISPR machinery that is normally used against them by bacterial cells. This paradox has now been explained, with implications for gene-therapy (...)

The digitization of organic synthesis

mercredi 12 juin 2019 par Ian W. Davies
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1288-yThis Perspective discusses the challenges associated with the prediction of chemical synthesis, in particular the reaction conditions required for organic transformations, and the role of machine-learning approaches in the (...)

Pluripotency and the origin of animal multicellularity

mercredi 12 juin 2019 par Shunsuke Sogabe, William L. Hatleberg, Kevin M. Kocot, Tahsha E. Say, Daniel Stoupin, Kathrein E. Roper, Selene L. Fernandez-Valverde, Sandie M. Degnan, Bernard M. Degnan
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1290-4Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells (...)

Hydraulic control of mammalian embryo size and cell fate

mercredi 12 juin 2019 par Chii Jou Chan, Maria Costanzo, Teresa Ruiz-Herrero, Gregor Mönke, Ryan J. Petrie, Martin Bergert, Alba Diz-Muñoz, L. Mahadevan, Takashi Hiiragi
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1309-xA mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their (...)

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