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Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes

mercredi 19 juin 2019 par Eachan O. Johnson, Emily LaVerriere, Emma Office, Mary Stanley, Elisabeth Meyer, Tomohiko Kawate, James E. Gomez, Rebecca E. Audette, Nirmalya Bandyopadhyay, Natalia Betancourt, Kayla Delano, Israel Da Silva, Joshua Davis, Christina Gallo, Michelle Gardner, Aaron J. Golas, Kristine M. Guinn, Sofia Kennedy, Rebecca Korn, Jennifer A. McConnell, Caitlin E. Moss, Kenan C. Murphy, Raymond M. Nietupski, Kadamba G. Papavinasasundaram, Jessica T. Pinkham, Paula A. Pino, Megan K. Proulx, Nadine Ruecker, Naomi Song, Matthew Thompson, Carolina Trujillo, Shoko Wakabayashi, Joshua B. Wallach, Christopher Watson, Thomas R. Ioerger, Eric S. Lander, Brian K. Hubbard, Michael H. Serrano-Wu, Sabine Ehrt, Michael Fitzgerald, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, Deborah T. Hung
Nature, Published online: 19 June 2019; doi:10.1038/s41586-019-1315-zA high-throughput chemical–genetic screening approach for the discovery of targets and chemicals to treat Mycobacterium tuberculosis yields tenfold more hit compounds than conventional whole-cell screening (...)

Robo-fish powered by battery ‘blood’

mercredi 19 juin 2019 par Nick Howe
Nature, Published online: 19 June 2019; doi:10.1038/d41586-019-01951-8Fluid gives robots power without adding weight — bringing them closer to autonomy.

A universal control system for synthetic gene networks

mercredi 19 juin 2019 par Noah Olsman, Johan Paulsson
Nature, Published online: 19 June 2019; doi:10.1038/d41586-019-01772-9A module for implementing robust feedback control in synthetic cellular networks has been reported. Its design is first proved mathematically to be universal for all networks, and then implemented in living (...)

Japan and Ukraine most likely to doubt safety of vaccines

mercredi 19 juin 2019 par Holly Else
Nature, Published online: 19 June 2019; doi:10.1038/d41586-019-01937-6But countries in South Asia and East Africa overwhelmingly agree vaccines are safe, global survey finds.

Podcast: Non-native species, and a blood-inspired robot battery

mercredi 19 juin 2019
Nature, Published online: 19 June 2019; doi:10.1038/d41586-019-01952-7Benjamin Thompson and Shamini Bundell bring you the latest science updates.

Egg pigmentation probably has an early Archosaurian origin

mercredi 19 juin 2019 par Matthew D. Shawkey, Liliana D’Alba
Nature, Published online: 19 June 2019; doi:10.1038/s41586-019-1282-4Egg pigmentation probably has an early Archosaurian origin

A skilful route out of academia

mercredi 19 juin 2019 par Nikki Forrester
Nature, Published online: 19 June 2019; doi:10.1038/d41586-019-01762-xCatriona Manville made the most of her work and volunteer experience to land a job outside academia that utilizes her research skills.

National food production stabilized by crop diversity

mercredi 19 juin 2019 par Delphine Renard, David Tilman
Nature, Published online: 19 June 2019; doi:10.1038/s41586-019-1316-yA greater diversity of crops at the national level increases the temporal stability of total national harvest, reflecting markedly lower frequencies of years with sharp harvest (...)

Mitochondrial fission requires DRP1 but not dynamins

mercredi 19 juin 2019 par Tiago Branco Fonseca, Ángela Sánchez-Guerrero, Ira Milosevic, Nuno Raimundo
Nature, Published online: 19 June 2019; doi:10.1038/s41586-019-1296-yMitochondrial fission requires DRP1 but not dynamins

The memory lanterns of Loi Krathong

mercredi 19 juin 2019 par Preston Grassmann
Nature, Published online: 19 June 2019; doi:10.1038/d41586-019-01910-3Something to share.

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