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Structure and autoregulation of a P4-ATPase lipid flippase

mercredi 26 juin 2019 par Milena Timcenko, Joseph A. Lyons, Dovile Januliene, Jakob J. Ulstrup, Thibaud Dieudonné, Cédric Montigny, Miriam-Rose Ash, Jesper Lykkegaard Karlsen, Thomas Boesen, Werner Kühlbrandt, Guillaume Lenoir, Arne Moeller, Poul Nissen
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1344-7Cryo-EM structures of the yeast P4-ATPase Drs2p–Cdc50p in three different states of activation provide insights into the function of this lipid flippase, including mechanisms of autoinhibition and PI4P-dependent (...)

Metabolic signal curbs cancer-cell migration

mercredi 26 juin 2019 par Lydia W. S. Finley
Nature, Published online: 26 June 2019; doi:10.1038/d41586-019-01934-9Metastasis, the migration of tumour cells from their primary site, is associated with poor prognosis. A molecule made during cell metabolism limits metastasis, revealing that this metabolite restrains cancer (...)

Walking on your sensitive sole

mercredi 26 juin 2019 par Kristiaan D’Août
Nature, Published online: 26 June 2019; doi:10.1038/d41586-019-01953-6Thick foot calluses develop naturally when walking barefoot. It emerges that they preserve foot sensitivity while offering protection, thus avoiding the trade-off between the two that occurs with cushioned (...)

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

mercredi 26 juin 2019 par Elizabeth J. Adams, Wouter R. Karthaus, Elizabeth Hoover, Deli Liu, Antoine Gruet, Zeda Zhang, Hyunwoo Cho, Rose DiLoreto, Sagar Chhangawala, Yang Liu, Philip A. Watson, Elai Davicioni, Andrea Sboner, Christopher E. Barbieri, Rohit Bose, Christina S. Leslie, Charles L. Sawyers
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1318-9Mutations in the transcription factor FOXA1 that are common in prostate cancer result in gain-of-function effects that promote changes in the differentiation of tumour (...)

Observing crystal nucleation in four dimensions using atomic electron tomography

mercredi 26 juin 2019 par Jihan Zhou, Yongsoo Yang, Yao Yang, Dennis S. Kim, Andrew Yuan, Xuezeng Tian, Colin Ophus, Fan Sun, Andreas K. Schmid, Michael Nathanson, Hendrik Heinz, Qi An, Hao Zeng, Peter Ercius, Jianwei Miao
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1317-xAtomic electron tomography captures crystal nucleation in four dimensions in FePt nanoparticles, with the observed early-stage nucleation not consistent with classical nucleation (...)

Author Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity

mercredi 26 juin 2019 par Jarosław M. Granda, Liva Donina, Vincenza Dragone, De-Liang Long, Leroy Cronin
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1218-zAuthor Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity

'I was dying of shame': Mexican science faces its #MeToo moment

mercredi 26 juin 2019 par Emiliano Rodríguez Mega
Nature, Published online: 26 June 2019; doi:10.1038/d41586-019-01376-3Outpouring of stories on social media prompts fierce debate about sexual harassment and assault at Mexico's research institutions.

Conformational transitions of a neurotensin receptor 1–Gi1 complex

mercredi 26 juin 2019 par Hideaki E. Kato, Yan Zhang, Hongli Hu, Carl-Mikael Suomivuori, Francois Marie Ngako Kadji, Junken Aoki, Kaavya Krishna Kumar, Rasmus Fonseca, Daniel Hilger, Weijiao Huang, Naomi R. Latorraca, Asuka Inoue, Ron O. Dror, Brian K. Kobilka, Georgios Skiniotis
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1337-6Cryo-electron microscopy structures of human neurotensin receptor 1 in complex with Gi1 protein and the agonist JMV449 reveal a non-canonical state that may represent an intermediate form in G-protein (...)

Can lasers really refrigerate CdS nanobelts?

mercredi 26 juin 2019 par Yurii V. Morozov, Shubin Zhang, Anupum Pant, Boldizsár Jankó, Seth D. Melgaard, Daniel A. Bender, Peter J. Pauzauskie, Masaru Kuno
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1269-1Can lasers really refrigerate CdS nanobelts?

Crystallization tracked atom by atom

mercredi 26 juin 2019 par Peter G. Vekilov
Nature, Published online: 26 June 2019; doi:10.1038/d41586-019-01965-2Atoms of a metal alloy have been tracked as they form crystal nuclei — the first ordered clusters of atoms or molecules produced during crystallization. The findings might help to develop a general nucleation (...)

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