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How 11 experts spent 2 days trying to find consensus on climate and conflict

mercredi 12 juin 2019
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01830-2Expert elicitation draws on diverse specialists to synthesize conflicting views and evidence.

A licence to kill during inflammation

mercredi 12 juin 2019 par Kengo Nozaki, Edward A. Miao
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01764-9Inflammasomes are protein complexes that fight infection by driving inflammation or cell death. It now seems that the protein NEK7 provides a ‘licence’ for the formation of inflammasomes containing the protein (...)

Migrant memory B cells secrete luminal antibody in the vagina

mercredi 12 juin 2019 par Ji Eun Oh, Norifumi Iijima, Eric Song, Peiwen Lu, Jonathan Klein, Ruoyi Jiang, Steven H. Kleinstein, Akiko Iwasaki
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1285-1In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary (...)

Magnetic record, space tourism and Sudan killings

mercredi 12 juin 2019
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01788-1The week in science: 7–13 June 2019.

Ozone mystery laid to rest

mercredi 12 juin 2019 par Mathew Evans
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01752-zMeasurements of atmospheric ozone levels taken during the nineteenth century cast doubt on the computational models used today to simulate the atmosphere. An independent proxy of past ozone levels offers (...)

Atypical behaviour and connectivity in SHANK3-mutant macaques

mercredi 12 juin 2019 par Yang Zhou, Jitendra Sharma, Qiong Ke, Rogier Landman, Jingli Yuan, Hong Chen, David S. Hayden, John W. Fisher III, Minqing Jiang, William Menegas, Tomomi Aida, Ting Yan, Ying Zou, Dongdong Xu, Shivangi Parmar, Julia B. Hyman, Adrian Fanucci-Kiss, Olivia Meisner, Dongqing Wang, Yan Huang, Yaqing Li, Yanyang Bai, Wenjing Ji, Xinqiang Lai, Weiqiang Li, Lihua Huang, Zhonghua Lu, Liping Wang, Sheeba A. Anteraper, Mriganka Sur, Huihui Zhou, Andy Peng Xiang, Robert Desimone, Guoping Feng, Shihua Yang
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1278-0The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid (...)

Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

mercredi 12 juin 2019 par Sanne E. Klompe, Phuc L. H. Vo, Tyler S. Halpin-Healy, Samuel H. Sternberg
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1323-zTransposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

Spin–orbit-driven band inversion in bilayer graphene by the van der Waals proximity effect

mercredi 12 juin 2019 par J. O. Island, X. Cui, C. Lewandowski, J. Y. Khoo, E. M. Spanton, H. Zhou, D. Rhodes, J. C. Hone, T. Taniguchi, K. Watanabe, L. S. Levitov, M. P. Zaletel, A. F. Young
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1304-2By enhancing the spin–orbit coupling in bilayer graphene using the proximity effect in a van der Waals heterostructure, band inversion occurs and an incompressible, gapped phase is (...)

Pluripotency and the origin of animal multicellularity

mercredi 12 juin 2019 par Shunsuke Sogabe, William L. Hatleberg, Kevin M. Kocot, Tahsha E. Say, Daniel Stoupin, Kathrein E. Roper, Selene L. Fernandez-Valverde, Sandie M. Degnan, Bernard M. Degnan
Nature, Published online: 12 June 2019; doi:10.1038/s41586-019-1290-4Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells (...)

Hijack of CRISPR defences by selfish genes holds clinical promise

mercredi 12 juin 2019 par Fyodor D. Urnov
Nature, Published online: 12 June 2019; doi:10.1038/d41586-019-01824-0Parasitic genetic elements called transposons carry CRISPR machinery that is normally used against them by bacterial cells. This paradox has now been explained, with implications for gene-therapy (...)

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