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Global surface warming enhanced by weak Atlantic overturning circulation

mercredi 18 juillet 2018 par Xianyao Chen, Ka-Kit Tung
Global surface warming enhanced by weak Atlantic overturning circulation Global surface warming enhanced by weak Atlantic overturning circulation, Published online: 18 July 2018; doi:10.1038/s41586-018-0320-yIn preindustrial times, a weak Atlantic Meridional Overturning Circulation led to (...)

The shieldin complex mediates 53BP1-dependent DNA repair

mercredi 18 juillet 2018 par Sylvie M. Noordermeer, Salomé Adam, Dheva Setiaputra, Marco Barazas, Stephen J. Pettitt, Alexanda K. Ling, Michele Olivieri, Alejandro Álvarez-Quilón, Nathalie Moatti, Michal Zimmermann, Stefano Annunziato, Dragomir B. Krastev, Feifei Song, Inger Brandsma, Jessica Frankum, Rachel Brough, Alana Sherker, Sébastien Landry, Rachel K. Szilard, Meagan M. Munro, Andrea McEwan, Théo Goullet de Rugy, Zhen-Yuan Lin, Traver Hart, Jason Moffat, Anne-Claude Gingras, Alberto Martin, Haico van Attikum, Jos Jonkers, Christopher J. Lord, Sven Rottenberg, Daniel Durocher
The shieldin complex mediates 53BP1-dependent DNA repair The shieldin complex mediates 53BP1-dependent DNA repair, Published online: 18 July 2018; doi:10.1038/s41586-018-0340-7The 53BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and (...)

Summer reads: Darwin’s dilemma on sexual selection, ecology versus empire, and the dark side of the greater good

mercredi 18 juillet 2018 par Andrew Jaffe, Fatimah Jackson, Elizabeth Yale, Adam Rome, Jennifer Rohn, Tim Radford, Alex Haslam, Diane Coyle
Summer reads: Darwin’s dilemma on sexual selection, ecology versus empire, and the dark side of the greater good Summer reads: Darwin’s dilemma on sexual selection, ecology versus empire, and the dark side of the greater good, Published online: 18 July 2018; doi:10.1038/d41586-018-05709-6Discover (...)

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

mercredi 18 juillet 2018 par Zachary Mirman, Francisca Lottersberger, Hiroyuki Takai, Tatsuya Kibe, Yi Gong, Kaori Takai, Alessandro Bianchi, Michal Zimmermann, Daniel Durocher, Titia de Lange
53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in, Published online: 18 July 2018; doi:10.1038/s41586-018-0324-753BP1 and shieldin recruit the CTC1–STN1–TEN1 complex and (...)

A record-breaking microscope

mercredi 18 juillet 2018 par John Rodenburg
A record-breaking microscope A record-breaking microscope, Published online: 18 July 2018; doi:10.1038/d41586-018-05711-yAn electron microscope has been developed that produces images at higher resolution than conventional approaches can achieve, and is suitable for studying fragile materials (...)

Photoswitching topology in polymer networks with metal–organic cages as crosslinks

mercredi 18 juillet 2018 par Yuwei Gu, Eric A. Alt, Heng Wang, Xiaopeng Li, Adam P. Willard, Jeremiah A. Johnson
Photoswitching topology in polymer networks with metal–organic cages as crosslinks Photoswitching topology in polymer networks with metal–organic cages as crosslinks, Published online: 18 July 2018; doi:10.1038/s41586-018-0339-0Using topology-switching metal–ligand cages to crosslink polymer (...)

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

mercredi 18 juillet 2018 par Di Wu, Di Hu, Hao Chen, Guoming Shi, Irfete S. Fetahu, Feizhen Wu, Kimberlie Rabidou, Rui Fang, Li Tan, Shuyun Xu, Hang Liu, Christian Argueta, Lei Zhang, Fei Mao, Guoquan Yan, Jiajia Chen, Zhaoru Dong, Ruitu Lv, Yufei Xu, Mei Wang, Yong Ye, Shike Zhang, Danielle Duquette, Songmei Geng, Clark Yin, Christine Guo Lian, George F. Murphy, Gail K. Adler, Rajesh Garg, Lydia Lynch, Pengyuan Yang, Yiming Li, Fei Lan, Jia Fan, Yang Shi, Yujiang Geno Shi
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer, Published online: 18 July 2018; doi:10.1038/s41586-018-0350-5Modulation of DNA 5-hydroxymethylcytosine (...)

Leaky pipeline for women scientists dries up after they win first big grant

mercredi 18 juillet 2018 par Holly Else
Leaky pipeline for women scientists dries up after they win first big grant Leaky pipeline for women scientists dries up after they win first big grant, Published online: 18 July 2018; doi:10.1038/d41586-018-05759-wOnce female scientists nab a US National Institutes of Health grant, their (...)

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

mercredi 18 juillet 2018 par Chamutal Bornstein, Shir Nevo, Amir Giladi, Noam Kadouri, Marie Pouzolles, François Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beáta Tóth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valérie S. Zimmermann, Jakub Abramson, Ido Amit
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells, Published online: 18 July 2018; doi:10.1038/s41586-018-0346-1A comprehensive characterization of the thymic stroma (...)

Accumulation of succinate controls activation of adipose tissue thermogenesis

mercredi 18 juillet 2018 par Evanna L. Mills, Kerry A. Pierce, Mark P. Jedrychowski, Ryan Garrity, Sally Winther, Sara Vidoni, Takeshi Yoneshiro, Jessica B. Spinelli, Gina Z. Lu, Lawrence Kazak, Alexander S. Banks, Marcia C. Haigis, Shingo Kajimura, Michael P. Murphy, Steven P. Gygi, Clary B. Clish, Edward T. Chouchani
Accumulation of succinate controls activation of adipose tissue thermogenesis Accumulation of succinate controls activation of adipose tissue thermogenesis, Published online: 18 July 2018; doi:10.1038/s41586-018-0353-2A comparative metabolomics approach is used to identify succinate as a key (...)

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